Is the Resistance of Large Conduit Arteries Also Decreased in Thyrotoxic Patients with Graves' Disease?

Czarkowski, Marek; Hilgertner, L.; Powałowski, T.; Radomski, Dariusz; Mikulska, Małgorzata

doi:10.1089/thy.2005.15.377

Cited by 4 publications

(7 citation statements)

References 11 publications

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“…The mean age of occurrence of cardiac complications of thyrotoxicosis as seen from this report is 40.8 years. The mean age of this group of people in this report though lower than that reported by Famuyiwa [10] is comparable to the more recent report by Danbauchi et al [14]. In this report, cardiac complications of thyrotoxicosis were noted 30.09±5.57 years.…”

Section: Discussionsupporting

confidence: 72%

“…Though cardiac complications of thyrotoxicosis had been reported to be more common in the elderly [13] but Nigerians had reported contrary to this observation [10-12]. The mean age of occurrence of cardiac complications of thyrotoxicosis as seen from this report is 40.8 years.…”

Section: Discussionmentioning

confidence: 54%

“…Thyroid hormones are known to affect the cardiovascular system both directly and indirectly [9] and results in increased cardiac contractility, enhanced cardiac output and reduced systemic vascular resistance. Incidence of thyrotoxic heart disease in sub-Saharan Africa ranged from 6.2-8% [10-12].…”

Section: Discussionmentioning

confidence: 99%

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ECG changes in patients with primary hyperthyroidism

Baladi¹,

Aslam²,

Ahmed³

2018

Pan Afr Med J

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IntroductionThyroid hormones plays key role in regulating cardiovascular system. Its imbalance leads to various electrophysiological changes in cardiovascular system. This study was done to determine the frequency of electrocardiographic (ECG) changes in patients with primary hyperthyroidism.MethodsIt was a descriptive cross-sectional study conducted in the Department of Medicine, Medical Unit III, Ward-7, Jinnah Postgraduate Medical Centre, Karachi, from October 2013 to April 2014. A total of 103 patients newly diagnosed with primary hyperthyroidism were included in this study. Venous blood samples were collected for T3, T3, TSH analyzed by radioimmunoassay. ECG was performed. Outcome variables were the ECG changes i.e. sinus tachycardia and atrial fibrillation.ResultsThe average age of the patients was 30.09±5.57 years (95%CI: 29 to 31.18). Out of 103 cases, 19 (18.45%) were male and 84 (81.55%) were female. Sinus tachycardia was observed in 60.19% (62/103) patients whereas atrial fibrillation was found in 11.65 (12/103) of cases.ConclusionIn this study frequency of electrocardiographic changes in term of sinus tachycardia was high. This report has emphasized the importance of thyrotoxicosis as a cause of cardiac morbidity and mortality in patients with thyrotoxicosis. These cardiac complications are readily reversible if timely optimal treatment is offered.

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Section: Discussionsupporting

confidence: 72%

Section: Discussionmentioning

confidence: 54%

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ECG changes in patients with primary hyperthyroidism

Baladi¹,

Aslam²,

Ahmed³

2018

Pan Afr Med J

View full text Add to dashboard Cite

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“…Only a few studies included a control group for comparison. Two studies performed pulse wave analysis from radial tonometry estimating Aix from recordings of the wave reflection [12,17], whereas 3 other studies assessed arterial stiffness using ultrasonic measurements of changes in large artery diameter [13][14][15].…”

Section: Discussionmentioning

confidence: 99%

“…The gold standard measurement of arterial stiffness is carotid-femoral pulse wave velocity (PWV) [10]. Only a few studies have been published on arterial stiffness in GD, and none of these assessed carotid-femoral PWV [11][12][13][14][15][16][17]. Increased arterial stiffness might provide a piece to the puzzle of the excess cardiovascular morbidity and mortality in GD.…”

Section: Introductionmentioning

confidence: 99%

Arterial Stiffness and Blood Pressure in Patients Newly Diagnosed with Graves’ Disease Compared with Euthyroid Controls

et al. 2020

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Introduction and Objective: The excess cardiovascular morbidity and mortality in hyperthyroidism and Graves' disease (GD) is inadequately understood. We aimed to elucidate whether well-established cardiovascular risk factors such as arterial stiffness in terms of pulse wave velocity (PWV) and blood pressure differ in GD and controls. Methods: This was a cross-sectional study comparing 55 hyperthyroid patients with newly diagnosed GD and 55 euthyroid, populationbased controls matched for age, sex and menopausal status. PWV and blood pressure were measured in office (Sphygmo-Cor Xcel) and 24-h ambulatory settings (Arteriograph). Differences between groups were assessed using adjusted linear regression analysis. Results: Compared to controls, GD patients showed higher PWV in the 24-h but not in the office setting with an adjusted 24-h PWV difference of 1.0 (95% CI: 0.6-1.5) m/s. PWV was higher in GD at both day and night, and nightly PWV dipping was lower (-5.5, 95% CI: -10.4 to -0.6%). Furthermore, central and brachial pulse pressure was significantly higher in both the office and 24-h setting, whereas nightly central pulse pressure dipping was significantly lower in GD (-5.4, 95% CI: -10.5 to -0.2%). Mean arterial pressure did not differ between the groups. Conclusions: Despite comparable blood pressure, GD is associated with a higher 24-h PWV that was not detected in the office setting. Pulse pressure was higher in GD, whereas mean arterial pressure did not differ between the groups. Longitudinal studies should pursue whether higher PWV might be a piece to the puzzle of understanding the increased risk of cardiovascular disease in hyperthyroidism and GD.

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Prevalence and pattern of thyroid disorders among patients attending University of Nigeria Teaching Hospital, Enugu, Southeastern Nigeria

et al. 2019

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Introduction: Thyroid disorders (TDs) remain the second-most common endocrine disease after diabetes worldwide. Recently, there has been increased interest in the prevalence and pattern of TD based on the fact that it accelerates cardiovascular complications. However, there are limited data on the prevalence and pattern of TDs in the University of Nigeria Teaching Hospital (UNTH) Enugu, Southeast Nigeria. Objectives: We studied prevalence and pattern of TDs as seen in patients attending UNTH, Enugu, Nigeria. Methods: This study was conducted in the Outpatient Department of UNTH Enugu from January 2016 to January 2019. Demographic and clinical data collected include age, gender, anthropometrics, clinical features, and associated complications of TDs. The patients were grouped as hyperthyroidism, hypothyroidism, and euthyroid sick syndrome (ESS) according to symptoms, signs, thyroid function test, liver function test, fasting blood sugar, and cholesterol. Results: A total of 260 patients (210 females and 50 males) with a mean age of 49.22 ± 9.79 years reflected overall prevalence rate of 2.4%. The prevalence of hyperthyroidism 150 (58%), hypothyroidism 100 (39%), and (ESS) 10 (3.9%) was 1.4%, 0.9%, and 0.09%, respectively. Hypertension 34.3%, heart failure 26.7%, and atrial fibrillation 20% seen in Grave's disease were the most common cause of hospitalization and death. Conclusion: Grave's disease is the most common cause of TDs and occurs more in females than males in this study. We observed that hypertension, heart failure, and atrial fibrillation are promoters of complication in TDs. Health system facilities need to be strengthened in this area to improve the detection and management of TDs.

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Is the Resistance of Large Conduit Arteries Also Decreased in Thyrotoxic Patients with Graves' Disease?

Cited by 4 publications

References 11 publications

ECG changes in patients with primary hyperthyroidism

ECG changes in patients with primary hyperthyroidism

Arterial Stiffness and Blood Pressure in Patients Newly Diagnosed with Graves’ Disease Compared with Euthyroid Controls

Prevalence and pattern of thyroid disorders among patients attending University of Nigeria Teaching Hospital, Enugu, Southeastern Nigeria

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