Is There a Correlation Between Coronary Artery Ectasia and Neutrophil–Lymphocyte Ratio?

Yalçın, Ahmet Arif; Topuz, Mustafa; Aktürk, İbrahim Faruk; Çelik, Ömer; Ertürk, Mehmet; Uzun, Fatih; Duran, Mustafa; Karadeniz, Muhammed; Sarikamiş, Çetin; Oner, Ender

doi:10.1177/1076029613520488

Cited by 10 publications

(9 citation statements)

References 30 publications

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“…As previously mentioned, CAE is an inflammatory process,12)13)14)17) and there is a study that proves it to be so. In a study conducted by Yalcin et al,17) there is a significant statistical result between NLR and CAE, and it was concluded that we can also evaluate these results by using Markis classification 18).…”

Section: Discussionmentioning

confidence: 93%

“…In a study conducted by Yalcin et al,17) there is a significant statistical result between NLR and CAE, and it was concluded that we can also evaluate these results by using Markis classification 18). Also, in another study, redcell-distribution (RDW) was used as an easily-accessible marker: Isik et al19) and Guo et al20) proposed some possible mechanistic explanations of the relationship between RDW and CAE, and found that elevation in the RDW values is associated with both the presence and severity of the CAE.…”

Section: Discussionmentioning

confidence: 97%

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The Relationship between Vitamin D and Coronary Artery Ectasia in Subjects with a Normal C-Reactive Protein Level

et al. 2017

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Background and ObjectivesVitamin D is generally known to be closely related to inflammation. The effects of vitamin D on coronary artery disease (CAD) are not fully explained. Nowadays, coronary artery ectasia (CAE) cases are common and are regarded as being a kind of CAD. We aimed to investigate, in a case-control study, the relationship between vitamin D and CAE without an associated inflammatory process.Subjects and MethodsThis study population included 201 patients (CAE group, 121 males; mean age, 61.2±6.4 years) with isolated CAE; and 197 healthy individuals (control group, 119 males; mean age, 62.4±5.8 years), comprising the control group, who had normal coronary arteries. These participants concurrently underwent routine biochemical tests, tests for inflammatory markers, and tests for 25-OH vitamin D in whole-blood draws. These parameters were compared.ResultsThere are no statistical significance differences among the groups for basic clinical characteristics (p>0.05). Inflammatory markers were recorded and compared to exclude any inflammatory process. All of them were similar, and no statistical significance difference was found. The average parathyroid hormone (PTH) level of patients was higher than the average PTH level in controls (41.8±15.1 pg/mL vs. 19.1±5.81 pg/mL; p<0.001). Also, the average 25-OH vitamin D level of patients was lower than the average 25-OH vitamin D level of controls (14.5±6.3 ng/mL vs. 24.6±9.3 ng/mL; p<0.001). In receiver operating characteristic curve analysis, the observed cut-off value for vitamin D between the control group and patients was 10.8 and 85.6% sensitivity and 75.2% specificity (area under the curve: 0.854, 95% confidence interval: 0.678-0.863).ConclusionWe found that there is an association between vitamin D and CAE in patients who had no inflammatory processes. Our study may provide evidence for the role of vitamin D as a non-inflammatory factor in the pathophysiology of CAE.

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Section: Discussionmentioning

confidence: 93%

Section: Discussionmentioning

confidence: 97%

The Relationship between Vitamin D and Coronary Artery Ectasia in Subjects with a Normal C-Reactive Protein Level

et al. 2017

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“…16 In addition, CRP, an easier, cheaper and more accessible infl ammatory biomarker, was found to be higher in CAE patients than normal controls. 17,18 Adhesion molecules are known to promote infl ammation by facilitating the activity of immune system cells. Plasma levels of these molecules, such as intercellular adhesion molecule-1 (ICAM-1), vascular adhesion molecule-1 (VCAM-1) and E-selectin, were found to be significantly higher in CAE patients.…”

Section: Discussionmentioning

confidence: 99%

Association Between Plasma Levels of Fibrinogen and the Presence and Severity of Coronary Artery Ectasia

Özde

Kayapınar

Afşin

2020

Sakarya Medical Journal

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Objective The aim of this study was to investigate the plasma fibrinogen levels in patients with isolated coronary artery ectasia (CAE). Materials and Methods The study population included 154 patients, of whom 52 had isolated CAE, 52 had stable coronary artery disease (CAD) and 50 had normal coronary arteries (NCA). The severity of isolated CAE was determined using the Markis classification. All the subjects underwent complete physical examinations, including a detailed medical history, complete blood count and biochemical parameters. Plasma fibrinogen levels also were measured in all subjects. Results The baseline characteristics of the three groups were similar. Plasma fibrinogen levels were significantly higher in the CAE group and CAD group than in the NCA group (383.3 ± 53.0 mg/dl and 400.8 ± 50.6 mg/dl vs 324.0 ± 56.4 respectively, p < 0.001). No difference was found between the CAE and CAD groups. The fibrinogen level was significantly higher in the type 1 Markis subgroup than in the type 2 and type 3 subgroups (P <0.001). In multivariate logistic regression analyses, fibrinogen level was independently and significantly associated with isolated CAE. Receiver operating characteristic curve analysis revealed that fibrinogen levels > 325 mg/dl identified patients with isolated CAE. Conclusions Plasma fibrinogen is an easily measurable systemic inflammatory biomarker that is independently associated with CAE presence and severity. This suggests that fibrinogen may be involved in the pathophysiology of CAE. Keywords coronary artery ectasia; fibrinogen; coronary artery disease Öz Amaç Bu çalışmanın amacı izole koroner arter ektazisi (KAE) olan hastalarda plazma fibrinojen düzeylerini araştırmaktı. Gereç ve Yöntemler Çalışma popülasyonunda 52'si izole KAE, 52'sinde koroner arter hastalığı (KAH) ve 50'sinde normal koroner arter (NKA) bulunan 154 hasta vardı. İzole KAE ciddiyeti Markis sınıflandırması kullanılarak belirlendi. Tüm hastalardan ayrıntılı tıbbi öykü alındı ve eksiksiz fizik muayene yapıldı. Tam kan sayımı ve biyokimyasal parametreler değerlendirildi. Tüm hastaların plazma fibrinojen düzeyleri de ölçüldü. Bulgular Üç grubun temel özellikleri benzerdi. Plazma fibrinojen düzeyleri KAE grubunda ve KAH grubunda NKA grubuna göre anlamlı derecede yüksekti (sırasıyla 383.3 ± 53.0 mg / dl ve 400.8 ± 50.6 mg / dl vs 324.0 ± 56.4, p <0.001). KAE ve KAH grupları arasında anlamlı fark saptanmadı. Fibrinojen düzeyi, tip 1 Markis alt grubunda, tip 2 ve tip 3 alt gruplarına göre anlamlı derecede yüksekti (p <0.001). Çok değişkenli lojistik regresyon analizlerinde fibrinojen düzeyi bağımsız ve anlamlı bir şekilde KAE ile ilişkili bulundu. İşlem karakteristik eğrisi analizinde, fibrinojen seviyelerinin >325 mg / dl olmasının KAE hastalarını tanımladığı saptandı. Sonuç Plazma fibrinojeni; KAE varlığı ve şiddeti ile bağımsız bir şekilde ilişkili olan, kolayca ölçülebilen sistemik inflamatuar bir biyobelirteçtir. Bu sonuçlar, fibrinojenin KAE patofizyolojisinde rol oynayabileceğini göstermektedir.

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“…18,20,21 Atherosclerosis is linked to aneurysm formation through a process of inflammation, extending into the tunica media, which eventually causes degeneration of the cystic media. 22 Prior studies have demonstrated that the elevation of inflammatory markers such as plasma soluble adhesion molecules, leukocytes, adiponectin, lipoprotein-associated phospholipase-A2, C-reactive protein, plasminogen activator inhibitor-1, IL-1, TNF-alfa and IL-10 are significantly in-Acta Cardiol Sin 2019;35: [20][21][22][23][24][25][26] Blood Viscosity and Coronary Artery Ectasia creased in patients with CAE. [4][5][6][7][8][9][10][11][12] In addition, NLR ratio, as a marker of inflammation, has been associated with atherosclerosis and CAE.…”

Section: Discussionmentioning

confidence: 99%

The Relationship between Blood Viscosity and Isolated Coronary Artery Ectasia

Çekici¹,

Kılıç²,

Saraçoğlu³

2018

The American Journal of Cardiology

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Is There a Correlation Between Coronary Artery Ectasia and Neutrophil–Lymphocyte Ratio?

Cited by 10 publications

References 30 publications

The Relationship between Vitamin D and Coronary Artery Ectasia in Subjects with a Normal C-Reactive Protein Level

The Relationship between Vitamin D and Coronary Artery Ectasia in Subjects with a Normal C-Reactive Protein Level

Association Between Plasma Levels of Fibrinogen and the Presence and Severity of Coronary Artery Ectasia

The Relationship between Blood Viscosity and Isolated Coronary Artery Ectasia

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