Is there a difference in risk factors for single and multiple symptomatic lesions in small vessel disease?

Postoperative neurological complications and risk factors for pre-existing silent brain infarction in elderly patients undergoing coronary artery bypass grafting

“…We also determined that hypertension was more common in patients with BI. Hypertension may lead to more severe progression of disease in cerebral vessels and produce multiple infarctions, which were demonstrated to be more frequent in patients with hypertension [25]. We found that preoperative cognitive impairment was common in patients with SBI and BI and was an independently associated factor for SBI.…”

Comparison of Risk Factor between Lacunar Stroke and Large Artery Atherosclerosis Stroke: A Cross-Sectional Study in China

“…Age was thought to be a significant risk factor in both LI and LAA groups in multivariate analysis by with previous reports [ 24 , 25 ]. One study found a slightly higher relation between age and small vessel disease than large vessel disease[ 16 ].…”

Association of plasma homocysteine concentration with cerebral white matter hyperintensity on magnetic resonance images in stroke patients

“…It has been suggested that although high blood pressure may facilitate development of white matter lesions, hypoperfusion caused by a decrease in blood pressure could accelerate their progression [34]. In line with this, a study investigating risk factors for multiple lacunar infarcts (known to be associated with cerebral SVD) showed that history of hypertension, higher systolic and mean blood pressure so as history of hypotensive events were all determinants for the condition [35]. As the effect of blood pressure could be opposite at different stages of white matter lesion development, studies simply exploring the association between hypertension and white matter change may lead to conflicting results.…”