2012
DOI: 10.1186/1746-1596-7-46
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Is there a link between diabetic glomerular injury and crescent formation? A case report and literature review

Abstract: Glomerular crescents are most commonly associated with rapidly progressive crescentic glomerulonephritis; however, they also develop in response to a wide range of primary and secondary glomerular injuries. Since various kind of glomerulopathies occasionally overlay diabetic glomerular injuries, the presence of crescents in renal biopsy specimens of diabetics may have stimulated a search for etiologies other than diabetes. In this report, we describe an unusual case of diabetic glomerulosclerosis with peculiar… Show more

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Cited by 23 publications
(18 citation statements)
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“…Further testing of effect modification by diabetes type is necessary. Before our study, there have been occasional case reports of "crescents" in DKD, [25][26][27] one of which had rapid progression of renal failure. 26 There are two case series of crescentic GN due to diabetes, but both reported a lower prevalence of EXHC (3%-5%) than in our cohort.…”
Section: Discussionmentioning
confidence: 91%
“…Further testing of effect modification by diabetes type is necessary. Before our study, there have been occasional case reports of "crescents" in DKD, [25][26][27] one of which had rapid progression of renal failure. 26 There are two case series of crescentic GN due to diabetes, but both reported a lower prevalence of EXHC (3%-5%) than in our cohort.…”
Section: Discussionmentioning
confidence: 91%
“…These lesions, resembling crescent-like structures, are a well-known pathological component of glomerulonephritis, affecting nearly 50% of overall glomerular circumference [41,42]. Yet, glomerular crescents development within diabetic kidney disease (DKD) has also been reported and is envisaged as a regular feature of glomerular changes within diabetes, although the available information is largely limited to the examination of human biopsies [43][44][45][46][47]. It is important to highlight that renal biopsies in diabetes are reserved for patients with atypical presentations in routinely clinical practice.…”
Section: Discussionmentioning
confidence: 99%
“…Otani et al recently reported a case of diabetic nodular glomerulosclerosis with crescent formation [4]. Laboratory studies showed no evidence of ANCA, anti-nuclear antibodies, anti-GBM antibodies, hepatitis B or C. The biopsy showed no evidence of vasculitis, fibrinoid necrosis, or GBM breaks.…”
Section: Discussionmentioning
confidence: 99%
“…They have been documented in a wide variety of glomerular diseases including IgA nephropathy and Alport syndrome [2,3]. Rare case reports have described crescents in patients with diabetic nephropathy [4-6]. This finding, however, has received little attention in the published literature to date.…”
Section: Introductionmentioning
confidence: 99%