Information from medical research should be used to optimize management for patients. In this issue, our group starts with a new item, that is, evidence-based case reports, which will provide answers to questions on common clinical problems on diagnosis, prognosis, or interventions in individual patient management in otolaryngology. An explicit and transparent approach is used to separate evidence from judgment in providing reliable updates on these specific patient management issues. These efforts may also prove to be very helpful to identify evidence gaps and provide recommendations for research priorities in otolaryngology.