Is there a need for special preventive medical check-ups in employees exposed to experimental animal dust?

Schmid, Klaus; Jüngert, Barbara; Hager, Meta; Drexler, Hans

doi:10.1007/s00420-008-0338-9

Cited by 9 publications

(5 citation statements)

References 19 publications

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“…Results of the study published by Schmid et al. confirmed the necessity of regular medical checkups for employees with contact to laboratory animal dust. The authors recommended that medical checkups must be part of a prevention strategy including education, engineering controls, administrative controls, use of personal protective equipment and vocational integration.…”

Section: Clinical Relevance Diagnosis and Managementmentioning

confidence: 70%

EAACI Molecular Allergology User's Guide

Matricardi

Kleine-Tebbe²,

Hoffmann

et al. 2016

Pediatric Allergy Immunology

741

870

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The availability of allergen molecules ('components') from several protein families has advanced our understanding of immunoglobulin E (IgE)-mediated responses and enabled 'component-resolved diagnosis' (CRD). The European Academy of Allergy and Clinical Immunology (EAACI) Molecular Allergology User's Guide (MAUG) provides comprehensive information on important allergens and describes the diagnostic options using CRD. Part A of the EAACI MAUG introduces allergen molecules, families, composition of extracts, databases, and diagnostic IgE, skin, and basophil tests. Singleplex and multiplex IgE assays with components improve both sensitivity for low-abundance allergens and analytical specificity; IgE to individual allergens can yield information on clinical risks and distinguish cross-reactivity from true primary sensitization. Part B discusses the clinical and molecular aspects of IgE-mediated allergies to foods (including nuts, seeds, legumes, fruits, vegetables, cereal grains, milk, egg, meat, fish, and shellfish), inhalants (pollen, mold spores, mites, and animal dander), and Hymenoptera venom. Diagnostic algorithms and short case histories provide useful information for the clinical workup of allergic individuals targeted for CRD. Part C covers protein families containing ubiquitous, highly cross-reactive panallergens from plant (lipid transfer proteins, polcalcins, PR-10, profilins) and animal sources (lipocalins, parvalbumins, serum albumins, tropomyosins) and explains their diagnostic and clinical utility. Part D lists 100 important allergen molecules. In conclusion, IgE-mediated reactions and allergic diseases, including allergic rhinoconjunctivitis, asthma, food reactions, and insect sting reactions, are discussed from a novel molecular perspective. The EAACI MAUG documents the rapid progression of molecular allergology from basic research to its integration into clinical practice, a quantum leap in the management of allergic patients.

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Section: Clinical Relevance Diagnosis and Managementmentioning

confidence: 70%

EAACI Molecular Allergology User's Guide

Matricardi

Kleine-Tebbe²,

Hoffmann

et al. 2016

Pediatric Allergy Immunology

741

870

View full text Add to dashboard Cite

show abstract

“…These check-ups comprised a questionnaire and a medical examination including pulmonary function tests. Work-related complaints occurred in 33.7% and 37.8% of employees occupationally exposed to mice and rats, respectively, and sensitization rates were 12.7 and 16.3%, respectively (39). These data confirm the necessity of regular medical check-ups for employees in contact with laboratory animal allergens.…”

Section: Discussionmentioning

confidence: 99%

Laboratory animals and respiratory allergies: The prevalence of allergies among laboratory animal workers and the need for prophylaxis

Ferraz¹,

Arruda²,

Bagatin³

et al. 2013

Clinics

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OBJECTIVE:Subjects exposed to laboratory animals are at a heightened risk of developing respiratory and allergic diseases. These diseases can be prevented by simple measures such as the use of personal protective equipment. We report here the primary findings of the Laboratory Animals and Respiratory Allergies Study regarding the prevalence of allergic diseases among laboratory animal workers, the routine use of preventive measures in laboratories and animal facilities, and the need for prevention programs.METHODS:Animal handlers and non-animal handlers from 2 Brazilian universities (University of São Paulo and State University of Campinas) answered specific questionnaires to assess work conditions and symptoms. These subjects also underwent spirometry, a bronchial challenge test with mannitol, and skin prick tests for 11 common allergens and 5 occupational allergens (rat, mouse, guinea pig, hamster, and rabbit).RESULTS:Four hundred fifty-five animal handlers (32±10 years old [mean±SD], 209 men) and 387 non-animal handlers (33±11 years old, 121 men) were evaluated. Sensitization to occupational allergens was higher among animal handlers (16%) than non-animal handlers (3%, p<0.01). Accessibility to personal protective equipment was measured at 85% (median, considering 73 workplaces of the animal handler group). Nineteen percent of the animal handlers indicated that they wear a respirator at all times while handling animals or working in the animal room, and only 25% of the animal handlers had received an orientation about animal-induced allergies, asthma, or rhinitis.CONCLUSION:In conclusion, our data indicate that preventive programs are necessary. We suggest providing individual advice to workers associated with institutional programs to promote a safer work environment.

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“…Two dog trainers with sensitization to dog (by using skin prick test) reported no clinical symptoms after exposure to dogs. Similarly in a laboratory workers study, it has been found that sensitization rates were 12.7 and 16.3% M a n u s c r i p t a c c e p t e d f o r p u b b l i c a t i o n exposed to mice and rats, respectively, and work-related complaints occurred in 33.7% and 37.8% of employees occupationally 24 .…”

Section: Discussionmentioning

confidence: 72%

Occupational allergy to dog among police dog trainers

Kesici

Karataþ

Ünlü

et al. 2019

Eur Ann Allergy Clin Immunol

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This study was aimed to reveal the prevalence of dog allergy and other common allergy and allergic symptoms in police dog trainers. Fifty-six police dog trainers and 150 workers as control group were included in this study. Medical records of dog trainers including respiratory, skin, eye symptoms and physical examinations and skin prick test results are compared with the medical records of control group. Positive SPT to dog was present in 21.4% of dog trainers, whereas the frequency of sensitization to dog in the control group was 1.3% (p<0.001). Dog allergy development risk is found 20 times greater in dog trainers than control group. In multiple logistic regression analysis it was found that atopy was associated with dog allergy likelihood. Sensitization to dog allergens is an important occupational problem for dog trainers.

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Is there a need for special preventive medical check-ups in employees exposed to experimental animal dust?

Cited by 9 publications

References 19 publications

EAACI Molecular Allergology User's Guide

EAACI Molecular Allergology User's Guide

Laboratory animals and respiratory allergies: The prevalence of allergies among laboratory animal workers and the need for prophylaxis

Occupational allergy to dog among police dog trainers

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