Is There a Regular Pattern in the Recovery of Parathyroid Function After Thyroid Cancer Surgery?

Yao, Xi-Yu; Zhou, Yan; Chen, Shun-Jin; Wu, Yu; Bian, Cong; Chen, Hongbin; Liu, Hui

doi:10.2147/cmar.s326705

Cited by 3 publications

(4 citation statements)

References 20 publications

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“…A total of 1743 articles were screened (Figure 1) and 237 full‐text articles were assessed for eligibility. After careful selection of the articles, 66 studies were eligible for the final synthesis and were included in this review 10,14,23,24,27‐88 …”

Section: Resultsmentioning

confidence: 99%

Management of Postthyroidectomy Hypoparathyroidism and Its Effect on Hypocalcemia‐Related Complications: A Meta‐Analysis

van Dijk,

van Driel,

van Kinschot

et al. 2023

Otolaryngol.--head neck surg.

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ObjectiveThe aim of this Meta‐analysis is to evaluate the impact of different treatment strategies for early postoperative hypoparathyroidism on hypocalcemia‐related complications and long‐term hypoparathyroidism.Data SourcesEmbase.com, MEDLINE, Web of Science Core Collection, Cochrane Central Register of Controlled Trials, and the top 100 references of Google Scholar were searched to September 20, 2022.Review MethodsArticles reporting on adult patients who underwent total thyroidectomy which specified a treatment strategy for postthyroidectomy hypoparathyroidism were included. Random effect models were applied to obtain pooled proportions and 95% confidence intervals. Primary outcome was the occurrence of major hypocalcemia‐related complications. Secondary outcome was long‐term hypoparathyroidism.ResultsSixty‐six studies comprising 67 treatment protocols and 51,096 patients were included in this Meta‐analysis. In 8 protocols (3806 patients), routine calcium and/or active vitamin D medication was given to all patients directly after thyroidectomy. In 49 protocols (44,012 patients), calcium and/or active vitamin D medication was only given to patients with biochemically proven postthyroidectomy hypoparathyroidism. In 10 protocols (3278 patients), calcium and/or active vitamin D supplementation was only initiated in case of clinical symptoms of hypocalcemia. No patient had a major complication due to postoperative hypocalcemia. The pooled proportion of long‐term hypoparathyroidism was 2.4% (95% confidence interval, 1.9‐3.0). There was no significant difference in the incidence of long‐term hypoparathyroidism between the 3 supplementation groups.ConclusionsAll treatment strategies for postoperative hypocalcemia prevent major complications of hypocalcemia. The early postoperative treatment protocol for postthyroidectomy hypoparathyroidism does not seem to influence recovery of parathyroid function in the long term.

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Section: Resultsmentioning

confidence: 99%

Management of Postthyroidectomy Hypoparathyroidism and Its Effect on Hypocalcemia‐Related Complications: A Meta‐Analysis

van Dijk,

van Driel,

van Kinschot

et al. 2023

Otolaryngol.--head neck surg.

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“…Enrollment criteria: (1) patient informed consent; (2) excluding patients with major systemic organ diseases and mental diseases; (3) total thyroid resection and central area lymph node dissection; (4) no iodine 131 treatment within 6 months; (5) no anticoagulant drugs like aspirin and rivaroxaban before surgery.…”

Section: Inclusion and Exclusion Criteriamentioning

confidence: 99%

“…Exclusion criteria: (1) patients with other serious chronic or disabled diseases or diseases, such as hypertension, diabetes, (2) patients cannot correctly understand and choose due to intellectual or mental factors (3) patients without central lymph node dissection (4) tumor tissue invasion of parathyroid and membrane tissue (5) in patients with bleeding tendency or use of anticoagulation, antiplatelet therapy or with hematopoietic disease (6) due to intraoperative operation or parathyroid glands unable to retain in situ.…”

Section: Inclusion and Exclusion Criteriamentioning

confidence: 99%

“…In the 151 patients in the anticoagulant group, susutong pills (Z19991025, Lunan Houpu Pharmaceutical Co., Ltd., speci cations: 12g / bottle, 1 bottle / time, tid), daheparin (company: Vetter Pharma-Fertigung GmbH & C o. KG, 2500 IU, ih, qd), vitamin D calcium masticatory tablets (the dose is calculated by the patient without clinical symptoms of hypocalcemia, including perioral numbness, numbness of both hands and feet, ankylosing hands and feet, or convulsions [5,6] ), Calcitriol therapy (Zhengda Pharmaceutical (Qingdao) Co., LTD., 1 grain, bid, po). A total of 110 patients in the control group had decreased parathyroid function after surgery, and vitamin D calcium masticatory tablets and calcitriol were used on the rst postoperative day.…”

Section: Treatment Regimenmentioning

confidence: 99%

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Clinical observation of choroidatong pill combined with daheline in the recovery of parathyroid function after total thyroidectomy

Liu

Chen

Kong

et al. 2023

Preprint

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Background:With the rapid rise of thyroid cancer incidence, how to prevent and deal with thyroid surgery postoperative complications is an important topic and challenge faced by surgeons. Among them, hypoparathyroidism is the most common complication after total thyroidectomy, which can significantly reduce the postoperative quality of life and increase the treatment cost of patients. Based on this, this study discusses the use of chorosutong pill and daheparin in the treatment of hypoparathyroidism after total thyroidectomy, which is intended to be. Methods: Using a retrospective analysis, A total of 928 thyroid cancer patients with total thyroid resection and lymph node dissection in the central district in the first ward of Breast and thyroid Surgery Department of Zibo Central Hospital from May 2021 to October 2022 were collected, A total of 261 patients had decreased parathyroid gland function after surgery; Among them, 151 patients (anticoagulant group) were given chorosutong pill combined with daheparin anticoagulation therapy and calcium supplement therapy on the first postoperative day, The 110 patients (control group) received only postoperative calcium supplementation, The incidence of permanent hypoparathyroidism, the average time to return to normal, the average postoperative extubation time and the average diversion flow of both groups were counted; The efficacy, serum PTH, and calcium values were compared between the two groups. Results: The incidence of permanent hypoparathyroidism in the anticoagulant group was 0%, The incidence of permanent hypoparathyroidism in the control group was 3.64%, The permanent parathyroid damage rate in the anticoagulant group was less than that in the control group (P <0.05), The mean postoperative extubation time between the two groups (P=0.28), There was no significant difference in mean postoperative diversion between the two groups (P=0.59), The postoperative parathyroid glands recovered significantly faster at 15,30,90 and 180 days than that in the control group (P <0.05); postoperative, The PTH index varied significantly between the two groups, The main manifestations are, as time goes on, The PTH measures were significantly higher in both groups, And Compared with the control group, The PTH was significantly higher in the anticoagulant group; postoperative, Significant differences in serum calcium index between the two groups, Both serum calcium indexes with the postoperative time, The expression was significantly elevated, And Compared with the control group, Serum calcium was significantly higher in the anticoagulant group; After intervention in both groups, There were significant differences in the efficacy, The main manifestation was that the treatment effect of the anticoagulant group was significantly better than that of the control group (P <0.05). Conclusion: Low parathyroid function occurs after total thyroidectomy, chorosutong pill and heparin anticoagulant therapy, can promote the recovery of parathyroid function, improve PTH and serum calcium, high clinical efficiency, and can reduce the incidence of permanent functional impairment, and use safe and reliable after surgery.

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The Effects of Radioiodine Therapy on the Recovery of Parathyroid Function in Patients with Protracted Hypoparathyroidism after Total Thyroidectomy for Papillary Thyroid Carcinoma

Abuduwaili

Baidula

Xia

et al. 2022

Journal of Investigative Surgery

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Is There a Regular Pattern in the Recovery of Parathyroid Function After Thyroid Cancer Surgery?

Cited by 3 publications

References 20 publications

Management of Postthyroidectomy Hypoparathyroidism and Its Effect on Hypocalcemia‐Related Complications: A Meta‐Analysis

Management of Postthyroidectomy Hypoparathyroidism and Its Effect on Hypocalcemia‐Related Complications: A Meta‐Analysis

Clinical observation of choroidatong pill combined with daheline in the recovery of parathyroid function after total thyroidectomy

The Effects of Radioiodine Therapy on the Recovery of Parathyroid Function in Patients with Protracted Hypoparathyroidism after Total Thyroidectomy for Papillary Thyroid Carcinoma

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