Is there a relationship between factor V Leiden and type 2 diabetes?

Lodigiani, Corrado; Ferrazzi, Paola; Micco, Pierpaolo Di; Librè, Luca; Genovese, Stefano; Quaglia, Ilaria; Rota, L.

doi:10.1186/1479-5876-7-52

Cited by 14 publications

(13 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…It has been reported that genetic factors could explain about 10 % of the variation in functional ability among older Danish male twins and 30 % among female twins (Christensen et al 2003). The ApoE gene is associated with Alzheimer Disease and heart diseases (Eichner et al 2002); other genetic abnormalities also are shown to be responsible for early-onset hypertension (Yang et al 2009) and diabetes (Lodigiani et al 2009). Furthermore, several localized samples have shown that interactions of ApoE-e4 with gender and baseline functional status predicted functional decline; the ApoE-e4 allele was not independently associated with declines in functional status or cognition (Blazer et al 2001).…”

Section: Genetic or Biological Factorsmentioning

confidence: 97%

Studying Disability Trends in Aging Populations

Gómez-Redondo

Dupre

2014

J Cross Cult Gerontol

View full text Add to dashboard Cite

This article reviews the current literature on disability trends in aging populations and proposes a framework for studying disability trends built upon existing models of disablement. In addition to considering disablement and its associated factors, our framework also includes factors at population level and the interplays among personal resources and health behaviors, intervention programs, technological advances, and the consequences of disability trends in the context of life course and socio-ecological perspective. The framework is abbreviated FE-BRIT-SE to denote individual-level (F)ixed attributes, including genetic factors, personality, age, sex, and earlier life conditions, and the (E)nvironment; individual (B)ehaviors, (R)esources, (I)nterventions, (T)echnology; and (S)ocioeconomic and (E)cological consequences of disability trends. The overview offers an integrated framework for understanding the disablement process, trends and their complex milieu of causes and consequences.

show abstract

Section: Genetic or Biological Factorsmentioning

confidence: 97%

Studying Disability Trends in Aging Populations

Gómez-Redondo

Dupre

2014

J Cross Cult Gerontol

View full text Add to dashboard Cite

show abstract

“…Diabetes may increase the levels of some coagulation factors and impair the fibrinolytic system, leading to a hypercoagulability state . Furthermore, compared with controls, an association has been reported between latent diabetes in carriers of factor V Leiden with previous VTE . Other factors that can contribute to prothrombotic status in diabetes include chronic inflammation, primary changes in haemostasis, enhanced oxidative stress and decreased expression of protective endothelial factors .…”

Section: Introductionmentioning

confidence: 99%

Type 2 diabetes is associated with a higher incidence of hospitalization for pulmonary embolism in Spain: Analysis of hospital discharge data during 2004–2013

et al. 2016

View full text Add to dashboard Cite

Background and objective: We compared the incidence and outcome of pulmonary embolism (PE) in individuals with and without type 2 diabetes mellitus (T2DM) in Spain during 2004-2013.Methods: The study was based on National Hospital Discharge Data, and the study population comprised patients hospitalized for PE. Annual incidence rates were classified according to T2DM status. In-hospital mortality (IHM), length of hospital stay (LOHS), comorbidities and use of diagnosis and therapeutic procedures were analysed. Results: We identified 123 872 discharges of patients (56 361 men and 67 511 women) with PE as their primary diagnosis (15.3% with T2DM). Incidence of discharge diagnoses of PE increased significantly in all groups. Crude rates were higher in diabetic patients. A positive association was identified between T2DM and PE: adjusted IRR was 2.00 (95% CI: 1.95-2.05) for men and 2.50 (95% CI: 2.45-2.57) for women. LOHS, readmissions and IHM decreased significantly for both groups. An association between IHM and risk factors (older age, Charlson comorbidity index >3, atrial fibrillation and cancer) was observed. T2DM was associated with higher IHM in men (OR: 1.22, 95% CI: 1.12-1.32) and women (OR: 1.24, 95% CI: 1.15-1.33). The use of computed tomography pulmonary angiography increased significantly overtime. Conclusion: We confirmed that in both men and women, diabetes was an independent risk factor for IHM. The incidence of discharge of patients with PE increased significantly during the study period. Diabetic

show abstract

“…Apart from the congenital defect mentioned above, acquired defects such as aberration in the vascular wall and stagnation of blood flow also cause thrombosis. ‘Economy class syndrome’ (deep venous thrombosis) is a representative condition of acquired thrombosis [3,4]. …”

Section: Introductionmentioning

confidence: 99%

In vivo Evaluation Method of the Effect of Nattokinase on Carrageenan-Induced Tail Thrombosis in a Rat Model

Kamiya¹,

Hagimori²,

Ogasawara³

et al. 2010

Acta Haematol

View full text Add to dashboard Cite

Thrombosis is characterized by congenital and acquired procatarxis. Nattokinase inhibits thrombus formation in vitro. However, in vivo evaluation of the therapeutic efficacy of nattokinase against thrombosis remains to be conducted. Subcutaneous nattokinase injections of 1 or 2 mg/ml were administered to the tails of rats. Subsequently, ĸ-carrageenan was intravenously administered to the tails at 12 h after nattokinase injections. The mean length of the infarcted regions in the tails of rats was significantly shorter in rats administered 2 mg/ml of nattokinase than those in control rats. Nattokinase exhibited significant prophylactic antithrombotic effects. Previously, the in vitro efficacy of nattokinase against thrombosis had been reported; now our study has revealed the in vivo efficacy of nattokinase against thrombosis.

show abstract

Is there a relationship between factor V Leiden and type 2 diabetes?

Cited by 14 publications

References 19 publications

Studying Disability Trends in Aging Populations

Studying Disability Trends in Aging Populations

Type 2 diabetes is associated with a higher incidence of hospitalization for pulmonary embolism in Spain: Analysis of hospital discharge data during 2004–2013

In vivo Evaluation Method of the Effect of Nattokinase on Carrageenan-Induced Tail Thrombosis in a Rat Model

Contact Info

Product

Resources

About