Is there a relationship between spontaneous GH secretion, anthropometric parameters and exercise capacity in healthy men over 50 years?

Micmacher, Eduardo; Conceição, Flávia Lúcia; Netto, Lino Sieiro; Redorat, Renato Galvão; Biesek, Simone; Gold, Jaime; Cenci, Maria Claudia Peixoto; Santos, Marco Aurélio dos; Taboada, Giselle F.; Assumpção, Roberto Pereira; Montenegro, F; Roisman, V.; Paula, Simone Kalil de

doi:10.1016/j.ghir.2007.07.010

Cited by 2 publications

(3 citation statements)

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“…Reports on the association between IGF‐I and body composition in older people have been variable. Some studies have shown a negative association between IGF‐I and weight, body mass index (BMI), waist‐hip ratio (WHR) or fat mass, 12–14 while others observed no association 3,15–17 . In women with a mean age of 55 years, a non linear relationship between IGF‐I and various indices of adiposity was observed 18 .…”

Section: Introductionmentioning

confidence: 99%

“…Some studies have shown a negative association between IGF-I and weight, body mass index (BMI), waist-hip ratio (WHR) or fat mass, [12][13][14] while others observed no association. 3,[15][16][17] In women with a mean age of 55 years, a non linear relationship between IGF-I and various indices of adiposity was observed. 18 A positive association between IGF-I levels and bone mineral density has been shown in older women and men, although this effect disappeared after correction for age in one of these studies.…”

Section: Introductionmentioning

confidence: 99%

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Serum insulin‐like growth factor‐I and body composition in community dwelling older people

Jakobsdottir

Nieuwpoort

Schaap³

et al. 2010

Clinical Endocrinology

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Serum insulin‐like growth factor‐I and body composition in community dwelling older people

Jakobsdottir

Nieuwpoort

Schaap³

et al. 2010

Clinical Endocrinology

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“…Twenty-nine subjects were screened for a project about somatotrophic profile in healthy men over 50 years old (which includes this paper) and have resulted in other published studies [15, 16]. After that, fourteen from the 29 initial patients agreed to participate in this part of the project that included the evaluation of muscle strength in GH x placebo replacement; those subjects who gave up had personal problems, such as work compromises and address change.…”

Section: Methodsmentioning

confidence: 99%

Effects of Growth Hormone Administration on Muscle Strength in Men over 50 Years Old

Tavares

Micmacher

Biesek

et al. 2013

International Journal of Endocrinology

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Growth hormone (GH) use has been speculated to improve physical capacity in subjects without GH deficiency (GHD) through stimulation of collagen synthesis in the tendon and skeletal muscle, which leads to better exercise training and increased muscle strength. In this context, the use of GH in healthy elderly should be an option for increasing muscle strength. Our aim was to evaluate the effect of GH therapy on muscle strength in healthy men over 50 years old. Fourteen healthy men aged 50–70 years were evaluated at baseline for body composition and muscle strength (evaluated by leg press and bench press exercises, which focus primarily on quadriceps—lower body part and pectoralis major—upper body part—muscles, resp.). Subjects were randomised into 2 groups: GH therapy (7 subjects) and placebo (7 subjects) and reevaluated after 6 months of therapy. Thirteen subjects completed the study (6 subjects in the placebo group and 7 subjects in the GH group). Subjects of both groups were not different at baseline. After 6 months of therapy, muscle strength in the bench press responsive muscles did not increase in both groups and showed a statistically significant increase in the leg press responsive muscles in the GH group. Our study demonstrated an increase in muscle strength in the lower body part after GH therapy in healthy men. This finding must be considered and tested in frail older populations, whose physical incapacity is primarily caused by proximal muscle weakness. The trial was registered with NCT01853566.

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Is there a relationship between spontaneous GH secretion, anthropometric parameters and exercise capacity in healthy men over 50 years?

Cited by 2 publications

References 31 publications

Serum insulin‐like growth factor‐I and body composition in community dwelling older people

Serum insulin‐like growth factor‐I and body composition in community dwelling older people

Effects of Growth Hormone Administration on Muscle Strength in Men over 50 Years Old

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