Is There A Role for Abscisic Acid, A Proven Anti-Inflammatory Agent, in the Treatment of Ischemic Retinopathies?

Abstract

Ischemic retinopathies (IRs) are the main cause of severe visual impairment and sight loss, and are characterized by loss of blood vessels, accompanied by hypoxia, and neovascularization. Actual therapies, based on anti-vascular endothelial growth factor (VEGF) strategies, antioxidants or anti-inflammatory therapies are only partially effective or show some adverse side effects. Abscisic acid (ABA) is a phytohormone present in vegetables and fruits that can be naturally supplied by the dietary intake and has been previously studied for its benefits to human health. It has been demonstrated that ABA plays a key role in glucose metabolism, inflammation, memory and tumor growth. This review focuses on a novel and promising role of ABA as a potential modulator of angiogenesis, oxidative status and inflammatory processes in the retina, which are the most predominant characteristics of the IRs. Thus, this nutraceutical compound might shed some light in new therapeutic strategies focused in the prevention or amelioration of IRs-derived pathologies.

Honey Phenolic Compound Profiling and Authenticity Assessment Using HRMS Targeted and Untargeted Metabolomics

“…Although abscisic acids are non-phenolic compounds, their presence in honey samples was investigated as they compose a significant part of honey’s bioactive content with many beneficial properties to human health [ 42 ]. The isomers of abscisic acid have been reported to encounter in many types of honey, which is also confirmed in this study [ 27 , 28 , 41 , 43 , 44 , 45 , 46 ].…”

Beneficial Contribution to Glucose Homeostasis by an Agro-Food Waste Product Rich in Abscisic Acid: Results from a Randomized Controlled Trial

“…Abscisic acid is widely described as a terpenoid phytohormone naturally present in fruits and vegetables [ 26 ], with a crucial role in controlling glucose homeostasis in humans [ 9 ]. This bioactive compound is currently and extensively being investigated for various therapeutic purposes, such as treatment of diabetes, cancer, ischemic retinopathy, and neurodegenerative diseases, due to its broad attributed biological activity spectrum [ 27 , 28 , 29 ]. The first aim of this study was to evaluate the potential beneficial effects on glucose homeostasis management after supplementation with two different doses of a TN-based nutraceutical product rich in ABA.…”

Central injection of abscisic acid attenuates mood disorders induced by subchronic stress in male mice

“…It has been shown that ABA is involved in inflammation and innate immune responses through activation of lanthionine synthetase Clike protein 2 (LANCL2)/PPARγ, which is known to regulate the inflammatory responses (Baliño et al, 2019). Guri et al has reported that dietary ABA supplementation ameliorates colonic inflammatory lesions through T-cell PPARγ-dependent mechanism (Guri et al, 2011).…”

“…It has been shown that ABA is involved in inflammation and innate immune responses through activation of lanthionine synthetase C‐like protein 2 (LANCL2)/PPARγ, which is known to regulate the inflammatory responses (Baliño et al., 2019 ). Guri et al.…”