Is There an Association between Asthma and Dental Caries and Molar Incisor Hypomineralisation?

Abstract

34This epidemiological study aimed to compare the caries and molar incisor hypomineralisation 35 (MIH) experience in asthmatic and non-asthmatic adolescents assessed at 10 and 15 years of 36 age. 730 adolescents from ongoing birth cohort studies (GINIplus/LISA) from Munich were 37 examined for carious lesions at the age of 10 and 15 to determine the caries experience under 38 inclusion of non-cavitated carious lesions D1-2T and the tooth-related decay-missing-filled 39 (DMFT) index. Furthermore, MIH was scored on all permanent teeth according to the criteria of 40 the European Academy of Paediatric Dentistry. The association of caries and MIH prevalence at 41 the 10-year and 15-year follow-up as well as caries incidence with ever having an asthma 42 diagnosis was analysed using hurdle regression models adjusted for potential confounders. Of 43 the 730 adolescents, 52 and 78 were identified as asthmatics at the 10-and 15-year follow-up, 44respectively. There were no significant differences in caries prevalence or experience between 45 asthma-free participants and any of the asthma groups (taking metered-dose inhaler (MDI) 46 medication vs. taking no MDI medication). However, a significant, positive association was 47 found for asthmatic adolescents who did not take MDI medication with higher MIH/T values 48 (OR=2.56, 95%CI=1.03-6.37, p=0.043) compared to non-asthmatics. In conclusion, asthma did 49 not influence the caries status of adolescents in the present study. Interestingly, a significant 50 association was found for adolescents with asthma who did not take MDI medication and the 51 number of MIH-affected teeth. The association between asthma, medication and MIH needs 52 further confirmation. 53 54 Material and Methods 103Study population 104

Molaren-Inzisiven-Hypomineralisation (MIH). Häufigkeit und mögliche Ursachen unter besonderer Berücksichtigung der Ergebnisse aus den Münchner Geburtskohorten GINIplus und LISA

“…Eine weiterführende Exploration der Daten unter Einbeziehung von Medikamenten oder Antibiotika war nicht möglich, da diese Informationen aus der frühkindlichen Lebensphase nur lückenhaft verfügbar waren. In einer weiteren Analyse wurde kein Zusammenhang zwischen dem Auftreten von Symptomen der Aufmerksamkeitsdefizit- und Hyperaktivitätsstörungen oder Asthma und MIH beobachtet [ 33 , 34 ].…”

“…Im Tierversuch interferieren Antibiotika mit dem Ameloblastenstoffwechsel, sodass ein beschleunigtes Wachstum der Schmelzprismen eintritt, ohne dass parallel dazu eine regelrechte Mineralisation der Zahnhartsubstanz vonstattengeht [ 38 ]. Bei den Betrachtungen zu einem möglichen Einfluss von Asthma [ 34 ] konnte zudem die Bedeutung der Asthmamedikation geprüft werden. Bei Asthmatikern, die auf den Gebrauch von Asthmasprays angewiesen waren, zeigte sich kein signifikanter Zusammenhang mit dem Auftreten einer MIH.…”

Lentes De Contato Dental: Revisão De Literatura

“…A Tabela 2 sintetiza os principais achados que podem estar associados à HMI. 2008KUHNISCH et al, 2014LIMA et al, 2015KIM et al, 2016THAKUR et al, 2020EMERICH, 2020 Bronquite KUSCU;CAGLAR;SANDALLI, 2008TOURINO et al, 2016ABBASOGLU;KARGUL, 2013ALLAZZAM;ALAKI;MELIGY, 2014TOURINO et al, 2016FLEXEDER et al, 2020GROEN, 2002SOUZA et al, 2012SONMEZ;YILDIRIM;BEZGIN, 2013ALLAZZAM;ALAKI;MELIGY, 2014KIM et al, 2016THAKUR et al, 2020FEARNE, 2008LAISI et al, 2009SOUZA et al, 2012ALLAZZAM;ALAKI;MELIGY, 2014WUOLLET et al, 2016KIM et al, 2016 Infecções (maioria dos estudos especifica como infecções amigdalite e otite). BEENTJES; WEERHEIJM; GROEN, 2002SOUZA et al, 2012ALLAZZAM;ALAKI;MELIGY, 2014PANDEY, 2016THAKUR et al, 2020 2009PITIPHAT et al, 2014 Problemas gastrointestinais SONMEZ; YILDIRIM; BEZGIN, 2013KUKLIK et al, 2020ZAMEER et al, 2020 Constante uso de medicamentos DURMUS; ABBASOGLU; KARGUL, 2013LOLI et al, 2015THAKUR et al, 2020 Tabela 2 -Fatores etiológicos associados à hipomineralização e as referências dos estudos que observaram essa associação Fonte: SANTOS-PINTO; FRAGELLI; IMPARATO, 2020 (adaptada).…”

Evaluation of blood and tooth element status in asthma cases: a preliminary case–control study

“…Interestingly, higher molar incisor hypomineralisation, a developmental enamel defect, was reported in asthma cases, previously [ 16 , 17 ]. Despite this, there was no published study in teeth element contents of asthma cases.…”