Is there an association between artificial sweetener consumption and assisted reproduction outcomes?

Setti, Amanda Souza; Braga, Daniela Paes de Almeida Ferreira; Halpern, Gabriela; Figueira, Rita de Cássia Sávio; Iaconelli, Assumpto; Borges, Edson

doi:10.1016/j.rbmo.2017.11.004

Cited by 19 publications

(23 citation statements)

References 40 publications

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“…The studies were performed internationally and included the following countries USA (n = 20) [15,[31][32][33][34][35][36][37][38][39][40][41][42][43][44][45], Australia (n = 1) [46], New Zealand (n = 1) [46], Ireland (n = 1) [46], United Kingdom (n = 2) [46,47], China (n = 1) [48], Denmark (n = 4) [41,43,49,50], Greece (n = 1) [14], Iran (n = 2) [51,52], Brazil (n = 2) [53,54], Canada (n = 1) [43], Russia (n = 1) [55], Italy (n = 2) [56,57], Spain (n = 1) [58]. The articles concerned female fertility and the intake of a Mediterranean dietary pattern (n = 2) [51,57], fruit, vegetables and whole grain intake (n = 3) [38,46,53], fish (n = 1) [42], dairy (n = 3) [15,43,44], types of fatty acids (n = 4) [39]…”

Section: Resultsmentioning

confidence: 99%

“…The articles concerned female fertility and the intake of a Mediterranean dietary pattern (n = 2) [51,57], fruit, vegetables and whole grain intake (n = 3) [38,46,53], fish (n = 1) [42], dairy (n = 3) [15,43,44], types of fatty acids (n = 4) [39][40][41], soy (n = 2) [32,33], caffeine (n = 3) [45,50,54], folate and B12 (n = 4) [34,35,59,60], melatonin (n = 1) [58], CoQ10 (n = 1) [48] as well as a combination of different compounds (n = 4) [37,47,52,55]. The women who participated in the studies were either planning pregnancy (n = 6) [36,40,41,45,46,55], infertile (n = 3) [49,51,55], undergoing or subjected to assistive reproductive technology (ART) therapy (n = 16) [14,15,31,34,35,39,42,44,50,[52]…”

Section: Resultsmentioning

confidence: 99%

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Emerging Trends in Research on Food Compounds and Women’s Fertility: A Systematic Review

et al. 2020

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Pro-healthy behaviours, including the diet, are significant factors in maintaining women’s fertility health. However, to improve the patient’s nutrition management, it is important to seek food-derived bioactive compounds to support fertility treatment. This review analysed recent studies of food compounds related to fertility, using databases including PubMed, Web of Science and Science Direct as well as PRISMA (preferred reporting items for systematic reviews) to ensure complete and transparent reporting of systematic reviews. This review lists foods associated with a higher birth rate, using original papers from the last five years (2015). The analysis included the impact of food compounds such as caffeine, fatty acids, folates and vitamin D, as well as the intake of fish, whole grains, dairy and soya. In addition, dietary patterns and total diet composition supporting women’s fertility were also analysed. The results will encourage further research on the relationship between food components and fertility.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Emerging Trends in Research on Food Compounds and Women’s Fertility: A Systematic Review

et al. 2020

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“…Recombinant follicle‐stimulating hormone (r‐FSH, Gonal‐F®, Serono, Geneve, Switzerland) and gonadotropin‐releasing hormone (GnRH) antagonist, cetrorelix acetate (Cetrotide; Serono Laboratories) were administered for ovarian stimulation, as previously described (Setti et al, ). Oocyte maturation was triggered with recombinant human chorionic gonadotrophin (hCG, Ovidrel™, Serono).…”

Section: Methodsmentioning

confidence: 99%

Paternal lifestyle factors in relation to semen quality and in vitro reproductive outcomes

et al. 2018

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This prospective-cohort study aimed at investigating the influence of paternal lifestyle factors on semen parameters and intracytoplasmic sperm injection (ICSI) outcomes. The influence of paternal lifestyle factors on seminal quality and ICSI outcomes was investigated in male patients undergoing conventional semen analysis. Cigarette smoking negatively influenced semen volume (B: -0.417, slope: 1.570, p = 0.047), sperm count/ml (B: -7.363, slope: 52.298, p = 0.014), total sperm count (B: -4.43, slope: 178.165, p = 0.023), total motile sperm count (B: -1.38, slope: 100.276, p = 0.045) and SDF (B: 0.014, slope: 9.767, p = 0.033). Alcohol consumption negatively influenced sperm count/ml (B: -12.527, slope: 42.255, p = 0.040) and sperm DNA fragmentation (B: 5.833, slope: 9.680, p = 0.002). There were no significant influences of other paternal lifestyle factors. Cigarette smoking negatively influenced the fertilisation rate (B: -1.349, slope: 21.950, p = 0.039) and the blastocyst formation rate (B: -14.244, slope: 28.851, p = 0.025). Alcohol consumption negatively influenced fertilisation rate (B: -3.617, slope: 20.138, p = 0.041) and blastocyst formation rate (B: -34.801, slope: 30.044, p = 0.042). Cigarette smoking and alcohol consumption appear to reduce semen quality, fertilisation and blastocyst formation rates; thus, it would be wise to recommend that male partners reconsider their lifestyle during in vitro reproduction treatment.

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“…Adverse human health effects from the application of artificial sweeteners (ASs) have been reported in several studies. Also unfavorable embryonic development was observed in women consuming artificially sweetened coffee (Setti et al, 2017). Since several sugar substitutes were shown to have adverse effects on public health (Ma et al, 2009;Steinert et al, 2011;Ford et al, 2011;Durán et al, 2018), that was also indicated by animal studies (Bellringer et al, 1995;Swithers et al, 2012;Jiang et al, 2018;Haighton et al, 2018), and in vitro studies (Pepino, 2015).…”

Section: Introductionmentioning

confidence: 96%

In Silico:Mutagenicity and carcinogenicity prediction of Sugar substitutes

Arulanandam

Babu²,

Soorni

et al. 2021

Preprint

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Sugar substitutes are mostly artificial, man-made industrial products used as additives in food and beverages. Most of these substances flow through the digestive tract and food chains to become emerging organic contaminants in various abiotic and biotic environmental media. Here, we predict the mutagenicity and carcinogenicity of commonly used sugar substitutes using the in silico based methods. The simplified molecular-input line-entry system (SMILES) of sugar substitutes were obtained from the PubChem database for the toxicity predictions. Here, sixteen sugar substitutes tested out of these four compounds Glucin (GLU), and 5-nitro-2-propoxyaniline (P-4000), SCL, Ace were predicted as mutagens by using in silico tools such as LAZAR, pKCSM, and Toxtree. Based on the predicted results GLU and P-4000 were predicted as carcinogenic sugar substitutes.

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Is there an association between artificial sweetener consumption and assisted reproduction outcomes?

Cited by 19 publications

References 40 publications

Emerging Trends in Research on Food Compounds and Women’s Fertility: A Systematic Review

Emerging Trends in Research on Food Compounds and Women’s Fertility: A Systematic Review

Paternal lifestyle factors in relation to semen quality and in vitro reproductive outcomes

In Silico:Mutagenicity and carcinogenicity prediction of Sugar substitutes

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