Is there an association between exposure to environmental estrogens and breast cancer?

Safe, Stephen

doi:10.1289/ehp.97105s3675

Cited by 45 publications

(14 citation statements)

References 51 publications

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“…For example, occupational exposure to relatively high levels of DDT/DDE were not associated with an increased incidence of breast cancer [83] and even after 20 years of follow-up, exposure to relatively high concentrations of DDE showed no evidence of contributing to an increased risk of breast cancer [84]. Recent and past exposure to DDT did not play an important role in the etiology of breast cancer not even among women living in a country with a tropical climate in the North of Vietnam where insecticide use for mosquito control is common [85].…”

Section: Organochlorine Pesticidesmentioning

confidence: 98%

Impact of Environmental Contaminants on Breast Cancer / Wpływ Zanieczyszczenia Środowiska Na Raka Piersi

Kráľová

Jampílek

2015

Ecological Chemistry and Engineering S

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Breast cancer is the most frequent cancer in women. It is believed that among the causes of breast cancer, hereditary factors account for only 5-10% of risk and the environmental exposures to environmental contaminants account for an additional 30-50% of risk. This paper summarizes findings related to the risk of breast cancer due to exposure to following environmental contaminants: polycyclic aromatic hydrocarbons, polychlorinated biphenyls and dioxins, organochlorine pesticides, organophosphorous pesticides, bisphenol A, phthalates, parabens, organic solvents, atmospheric pollutants, alkylphenols, metals, ionizing radiation, electromagnetic field and light pollution. Results obtained in in vitro experiments with breast cancer cell lines and in vivo with model rodents as well as in population based case-control studies are presented and the mode of action of individual environmental contaminants on mammary gland is discussed. Attention is also devoted to the effects of the timing of exposure to environmental contaminants (mainly exposition during development of the mammary gland) on breast cancer risk. Outcomes of professional exposure to some environmental contaminants on breast cancer risk are analysed as well.

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Section: Organochlorine Pesticidesmentioning

confidence: 98%

Impact of Environmental Contaminants on Breast Cancer / Wpływ Zanieczyszczenia Środowiska Na Raka Piersi

Kráľová

Jampílek

2015

Ecological Chemistry and Engineering S

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“…These compounds were used widely in industry for a wide variety of purposes, ranging from plastic resins to carbonless copy paper. Despite their utility, PCBs are linked to environmental and human health risks [32,33] that have resulted in the subsequent banning or highly restricted use of PCBs in many countries. However, it is estimated that >1 million tons of PCBs have been produced, and >70% of the PCBs made are still in use [34,35].…”

Section: Polychlorinated Biphenyls and Endometrial Cancermentioning

confidence: 99%

Endocrine Disrupting Chemicals and Endometrial Cancer: An Overview of Recent Laboratory Evidence and Epidemiological Studies

Mallozzi¹,

Leone²,

Manurita³

et al. 2017

IJERPH

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Background: Although exposure to endocrine disruptor compounds (EDCs) has been suggested as a contributing factor to a range of women’s health disorders including infertility, polycystic ovaries and the early onset of puberty, considerable challenges remain in attributing cause and effect on gynaecological cancer. Until recently, there were relatively few epidemiological studies examining the relationship between EDCs and endometrial cancer, however, in the last years the number of these studies has increased. Methods: A systematic MEDLINE (PubMed) search was performed and relevant articles published in the last 23 years (from 1992 to 2016) were selected. Results: Human studies and animal experiments are confirming a carcinogenic effect due to the EDC exposure and its carcinogenesis process result to be complex, multifactorial and long standing, thus, it is extremely difficult to obtain the epidemiological proof of a carcinogenic effect of EDCs for the high number of confusing factors. Conclusions: The carcinogenic effects of endocrine disruptors are plausible, although additional studies are needed to clarify their mechanisms and responsible entities. Neverthless, to reduce endocrine disruptors (ED) exposure is mandatory to implement necessary measures to limit exposure, particularly during those periods of life most vulnerable to the impact of oncogenic environmental causes, such as embryonic period and puberty.

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“…Environmental estrogen mimics are also implicated as endocrine disruptors in wildlife species. Although there is experimental evidence on the estrogenicity of several chlorinated pesticides (including DDT), as mentioned above, recent epidemiologic studies find no increased risk of breast cancer with pesticide exposure (102)(103)(104). Furthermore, in view of the presence of natural hormone and antihormone mimics in our diet, Safe and Zacharewski (105) concluded that the estrogenic contribution of organochlorine compounds is small and their role in development of breast cancer is questionable.…”

Section: Breast Cancer and Organochlorine Pollutantsmentioning

confidence: 99%

Perspectives on the chemical etiology of breast cancer.

DeBruin

Josephy

2002

Environ Health Perspect

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Is there an association between exposure to environmental estrogens and breast cancer?

Abstract: It was initially reported that levels of polychlorinated biphenyls (PCBs) 675-678 (1997)

Cited by 45 publications

References 51 publications

Impact of Environmental Contaminants on Breast Cancer / Wpływ Zanieczyszczenia Środowiska Na Raka Piersi

Impact of Environmental Contaminants on Breast Cancer / Wpływ Zanieczyszczenia Środowiska Na Raka Piersi

Endocrine Disrupting Chemicals and Endometrial Cancer: An Overview of Recent Laboratory Evidence and Epidemiological Studies

Perspectives on the chemical etiology of breast cancer.

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