Is There Any Relationship between Plasma 25-Hydroxyvitamin D3, Adipokine Profiles and Excessive Body Weight in Type 2 Diabetic Patients?

Kocot, Joanna; Dziemidok, Piotr; Kiełczykowska, Małgorzata; Kurzepa, Jacek; Szczęśniak, Grzegorz; Musik, Irena

doi:10.3390/ijerph15010019

Cited by 9 publications

(6 citation statements)

References 52 publications

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“…Further, the relationship between resistin and vitamin D has only been examined in a few studies. However, these studies mainly involved obese subjects and related diseases, as well as diseases involving chronic inflammation [ 31 , 32 ]. Increased levels of resistin in the muscle cell during exercise appear to be the factor limiting exercise capacity, and the observation that vitamin D supplementation lowers resistin levels is notable.…”

Section: Discussionmentioning

confidence: 99%

Single High-Dose Vitamin D Supplementation as an Approach for Reducing Ultramarathon-Induced Inflammation: A Double-Blind Randomized Controlled Trial

et al. 2021

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Purpose: A growing number of studies indicate the importance of vitamin D supplementation for sports performance. However, the effects of a single high-dose vitamin D supplementation on ultramarathon-induced inflammation have not been investigated. We here analyzed the effect of a single high-dose vitamin D supplementation on the inflammatory marker levels in ultramarathon runners after an ultramarathon run (maximal run 240 km). Methods: In the study, 35 runners (amateurs) were assigned into two groups: single high-dose vitamin D supplementation group, administered vitamin D (150,000 IU) in vegetable oil 24 h before the start of the run (n = 16); and placebo group (n = 19). Blood was collected for analysis 24 h before, immediately after, and 24 h after the run. Results: Serum 25(OH)D levels were significantly increased after the ultramarathon in both groups. The increase was greater in the vitamin D group than in the control group. Based on post-hoc and other analyses, the increase in interleukin 6 and 10, and resistin levels immediately after the run was significantly higher in runners in the control group than that in those in the supplementation group. Leptin, oncostatin M, and metalloproteinase tissue inhibitor levels were significantly decreased in both groups after the run, regardless of the supplementation. Conclusions: Ultramarathon significantly increases the serum 25(OH)D levels. Attenuation of changes in interleukin levels upon vitamin D supplementation confirmed that vitamin D has anti-inflammatory effect on exercise-induced inflammation.

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Section: Discussionmentioning

confidence: 99%

Single High-Dose Vitamin D Supplementation as an Approach for Reducing Ultramarathon-Induced Inflammation: A Double-Blind Randomized Controlled Trial

et al. 2021

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“…There have been published several studies describing pregnancy-related LCN2. However, we have found very few articles analyzing LCN2 in relation to GDM [ 41 – 44 ].…”

Section: Discussionmentioning

confidence: 99%

“…Additionally, in our study, in the GDM group, the weak positive correlation between LCN2 levels and maternal age at the blood collection has been noticed. The relationship between age and adipokine levels is ambiguous [ 44 ]. There appear to be no data in the literature on the possible mechanisms of such correlation and clinical implications, and we cannot compare our findings with other publications.…”

Section: Discussionmentioning

confidence: 99%

The Potential Role of Chemerin, Lipocalin 2, and Apelin in the Diagnosis and Pathophysiology of Gestational Diabetes Mellitus

Mierzyński

Poniedziałek‐Czajkowska

Dłuski

et al. 2021

Journal of Diabetes Research

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The exact role of adipokines in the pathogenesis of gestational diabetes mellitus (GDM) still remains not fully clear, and multiple studies have analyzed their potential contribution to the pathophysiology of this pregnancy complication. This study is aimed at evaluating serum chemerin, lipocalin 2, and apelin concentrations in GDM and healthy pregnant patients, assessing the correlation between these adipokines, and suggesting the potential role of these cytokines in the diagnosis and pathophysiology of GDM. The study comprised 237 pregnant women: 153 with GDM and 84 with physiological pregnancy. Serum concentrations of chemerin, lipocalin 2, and apelin were obtained at 24–29 weeks of gestation. The mean concentrations of chemerin and lipocalin 2 were significantly higher in the GDM group. The concentration of apelin was slightly higher in the GDM group, but not statistically significant. The strong positive correlation between chemerin and lipocalin 2 concentrations was noticed in both groups. Our data suggest that maternal chemerin and lipocalin 2 may play a significant role in the pathophysiology of GDM. We imply that these adipokines could potentially be established as novel biomarkers for the early identification of GDM. However, more studies are needed to analyze the effect of these adipokines on glucose metabolism during early pregnancy.

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“…In addition, in our study we found an inverse relationship between 25(OH)D and 25(OH)D 3 status with BMI. Sousa-Santos et al [53] found this correlation between BMI and vitamin D status, although they also failed to discern between the different metabolites of vitamin D. Other authors, such as Liu et al [54] and Kocot et al [55], support the role that BMI has on vitamin D 3 status (r = 0.09, p = 0.01), although they did not assess whether this association was influenced by total body fat as we demonstrated in our results. The prevalence of obesity, associated with a reduced quality of life, morbidity and mortality, underscores the need for a food reeducation program during the postmenopausal period [56].…”

Section: Discussionmentioning

confidence: 94%

Association between Body Fatness and Vitamin D3 Status in a Postmenopausal Population

et al. 2020

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Vitamin D is a micronutrient that plays a key role in phosphocalcic metabolism. The postmenopausal population presents a risk of deficiency in this vitamin due to hormonal alterations which, in the case of obesity, would be exacerbated. The objective was to assess the status of vitamin D in a postmenopausal population and determine the relationship of 25-hydroxivitamin D [25(OH)D] and its metabolites with anthropometric parameters. The study included 78 healthy postmenopausal women aged from 44 to 76. The nutrient intake assessment was carried out using the 24 h reminder (R24h). 25(OH)D was analyzed using ultra-high-performance liquid chromatography (UHPLC). A total of 80% and 68% of the women studied did not reach sufficient values of 25(OH)D and 25-hydroxivitamin D 3 [25(OH)D 3 ], respectively, which was inversely correlated with Body Mass Index (BMI) (r = −0.25, p = 0.04), hip perimeter (r = −0.26 and r = −0.24, all p < 0.05), arm circumference (r = −0.29, p = 0.01) and fat mass (r = −0.28 and r = −0.26, all p < 0.05). 25(OH)D 3 is the metabolite that contributed most to this association. In conclusion, 25(OH)D 3 levels are related to anthropometric parameters in the postmenopausal women in this study, confirming insufficient status in the majority of the population. Approach strategies are necessary to correct and avoid this risk in order to ensure future quality of life.

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Is There Any Relationship between Plasma 25-Hydroxyvitamin D3, Adipokine Profiles and Excessive Body Weight in Type 2 Diabetic Patients?

Cited by 9 publications

References 52 publications

Single High-Dose Vitamin D Supplementation as an Approach for Reducing Ultramarathon-Induced Inflammation: A Double-Blind Randomized Controlled Trial

Single High-Dose Vitamin D Supplementation as an Approach for Reducing Ultramarathon-Induced Inflammation: A Double-Blind Randomized Controlled Trial

The Potential Role of Chemerin, Lipocalin 2, and Apelin in the Diagnosis and Pathophysiology of Gestational Diabetes Mellitus

Association between Body Fatness and Vitamin D3 Status in a Postmenopausal Population

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