Is there any role for allergen avoidance in the primary prevention of childhood asthma?

Schayck, Onno C. P. van; Maas, Tanja; Kaper, Janneke; Knottnerus, André; Sheikh, Aziz

doi:10.1016/j.jaci.2007.02.024

Cited by 65 publications

(38 citation statements)

References 36 publications

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“…DOI: 10.1183/09031936.00084114of being successful [103,107]. For food allergens, however, there is evidence to suggest that early exposure prevents allergic sensitisation [108].…”

Section: Early-life Origins Of Chronic Respiratory Diseases | S Carrmentioning

confidence: 99%

Early-life origins of chronic respiratory diseases: understanding and promoting healthy ageing

et al. 2014

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Chronic obstructive respiratory disorders such as asthma and chronic obstructive pulmonary disease often originate early in life. In addition to a genetic predisposition, prenatal and early-life environmental exposures have a persistent impact on respiratory health. Acting during a critical phase of lung development, these factors may change lung structure and metabolism, and may induce maladaptive responses to harmful agents, which will affect the whole lifespan.Some environmental factors, such as exposure to cigarette smoke, type of childbirth and diet, may be modifiable, but it is more difficult to influence other factors, such as preterm birth and early exposure to viruses or allergens.Here, we bring together recent literature to analyse the critical aspects involved in the early stages of lung development, going back to prenatal and perinatal events, and we discuss the mechanisms by which noxious factors encountered early on may have a lifelong impact on respiratory health.We briefly comment on the need for early disease biomarkers and on the possible role of ''-omic'' technologies in identifying risk profiles predictive of chronic respiratory conditions. Such profiles could guide the ideation of effective preventive strategies and/or targeted early lifestyle or therapeutic interventions. @ERSpublications Early-life factors have a role in onset of asthma and COPD; early postnatal interventions may promote lung health http://ow.ly/BvUrx

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“…DOI: 10.1183/09031936.00084114of being successful [103,107]. For food allergens, however, there is evidence to suggest that early exposure prevents allergic sensitisation [108].…”

Section: Early-life Origins Of Chronic Respiratory Diseases | S Carrmentioning

confidence: 99%

Early-life origins of chronic respiratory diseases: understanding and promoting healthy ageing

et al. 2014

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“…A meta-analysis found that studies of interventions focused on reducing exposure to a single allergen did not significantly affect asthma development, but that multifaceted interventions such as in the Isle of Wight study, 506 the Canadian Asthma Primary Prevention Study, 507 and the Prevention of Asthma in Children study 508 were associated with lower risk of asthma diagnosis in children younger than 5 years. 509 Two multifaceted studies that followed children beyond 5 years of age demonstrated a significant protective effect both before and after the age of 5 years. 506,510 The Isle of Wight study has shown a continuing positive benefit for early-life intervention through to 18 years of age; 511 however, exactly which components of the intervention were important and which specific mechanistic changes were induced remain elusive.…”

Section: Inhalant Allergensmentioning

confidence: 99%

Mortality in Asthma-Chronic Obstructive Pulmonary Disease Overlap in the United States

Kumbhare

Strange

2018

Southern Medical Journal

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“…La evidencia de la asociación lineal entre la exposición a los alérgenos de los ácaros del polvo doméstico, la sensibilización y el desarrollo de asma no es unánime. 22,[23][24][25] Los resultados surgen de protocolos de estudios con diferente metodología y difícil comparación, y con insuficiente período de seguimiento, lo que imposibilita la evaluación de la perdurabilidad del efecto y conlleva la falta de control de factores de confusión y, en la práctica, la dificultad de aplicación a toda la población de riesgo. 26 Los estudios intervencionistas también arrojaron resultados diferentes e, incluso, paradojales, con aumento de la sensibilización a pesar de las medidas de reducción de la exposición.…”

Section: Humo Del Tabacounclassified

Prevención de las enfermedades alérgicas en la infancia: entre la teoría y la realidad

2016

Arch Argent Pediat

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RESUMENLas enfermedades alérgicas tienen una prevalencia creciente de modo universal y ocasionan alto impacto sanitario. La investigación está dirigida al estudio de los factores etiológicos y de riesgo de estas enfermedades, que pueden ser potencialmente modificados con estrategias de prevención primaria, secundaria y terciaria. Muchas de esas medidas no tienen un efecto comprobado de manera definitiva, dado que se realizan en un contexto controlado diferente a lo que ocurre en la vida real. Este documento tiene por objetivo revisar las evidencias más actuales sobre prevención de las enfermedades alérgicas considerando las certezas y cuestiones por resolver, y está especialmente centrado en las medidas ambientales, dietéticas, farmacológicas e inmunológicas para los distintos niveles preventivos. Es imperativo un mejor conocimiento de genes y factores ambientales responsables de las enfermedades alérgicas para optimizar las medidas preventivas que permitan revertir la creciente prevalencia de estas enfermedades en la infancia. Palabras clave: alergia, prevención, asma, control ambiental, inmunoterapia. ABSTRACTAllergic diseases have an increasing worldwide prevalence and a great impact on the health related costs. The research is focused on the study of etiological and risk factors of allergic diseases that can potentially be modified with primary, secondary and tertiary prevention strategies. Many of these measures do not have a definitively proven effect taking place in a controlled context different to what happens in real life. This paper aims to review the latest evidence on prevention of allergic diseases considering certainties and unresolved issues and focuses mainly on environmental, dietary, pharmacological and immunological preventive strategies for different levels of prevention. It is imperative to have a better understanding of genetic and environmental factors that cause allergic diseases to optimize preventive measures that are effective in reversing the increasing trend in the prevalence of allergic illnesses in childhood. Key words : allergy, prevention, asthma, environmental control, immunotherapy. http://dx.doi.org/10.5546/aap.2016.277 INTRODUCCIÓNL a s e n f e r m e d a d e s a l é r g i c a s constituyen las patologías crónicas más frecuentes en la edad pediátrica, c o n e l e v a d o s c o s t o s s a n i t a r i o s para el diagnóstico y tratamiento y afectación de la calidad de vida.1 . En Latinoamérica, aproximadamente el Comité Nacional de Alergia Documento de toma de posición Documento desarrollado en el marco del 50° aniversario del

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Is there any role for allergen avoidance in the primary prevention of childhood asthma?

Cited by 65 publications

References 36 publications

Early-life origins of chronic respiratory diseases: understanding and promoting healthy ageing

Early-life origins of chronic respiratory diseases: understanding and promoting healthy ageing

Mortality in Asthma-Chronic Obstructive Pulmonary Disease Overlap in the United States

Prevención de las enfermedades alérgicas en la infancia: entre la teoría y la realidad

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