Is there anything distinctive about epileptic deja vu?

Warren‐Gash, Charlotte; Zeman, Adam

doi:10.1136/jnnp-2012-303520

Cited by 34 publications

(32 citation statements)

References 15 publications

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“…It is considered to be a memory-based illusion resulting from aberrant neural activity among memory-related brain systems, particularly within the medial temporal lobes (MTL; Bartolomei et al 2004;Illman et al 2012;O'Connor and Moulin 2010). Consistent with this notion, the Bdreamy state^reported frequently at the beginning of seizures by patients with medial temporal lobe epilepsy (TLE) often comprises the sensation of inappropriate familiarity characterising DV (e.g., Vignal et al 2007;Warren-Gash and Zeman 2014). Physiological equivalence between the ictal experience of DVand that experienced by healthy individuals remains uncertain, however, and the task now is to understand more precisely the neural events underlying its benign manifestation.…”

Section: Introductionmentioning

confidence: 91%

Structural covariance mapping delineates medial and medio-lateral temporal networks in déjà vu

Shaw

Mareček

Brázdil

2015

Brain Imaging and Behavior

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Déjà vu (DV) is an eerie phenomenon experienced frequently as an aura of temporal lobe epilepsy, but also reported commonly by healthy individuals. The former pathological manifestation appears to result from aberrant neural activity among brain structures within the medial temporal lobes. Recent studies also implicate medial temporal brain structures in the non-pathological experience of DV, but as one element of a diffuse neuroanatomical correlate; it remains to be seen if neural activity among the medial temporal lobes also underlies this benign manifestation. The present study set out to investigate this. Due to its unpredictable and infrequent occurrence, however, non-pathological DV does not lend itself easily to functional neuroimaging. Instead, we draw on research showing that brain structure covaries among regions that interact frequently as nodes of functional networks. Specifically, we assessed whether grey-matter covariance among structures implicated in non-pathological DV differs according to the frequency with which the phenomenon is experienced. This revealed two diverging patterns of structural covariation: Among the first, comprised primarily of medial temporal structures and the caudate, grey-matter volume becomes more positively correlated with higher frequency of DV experience. The second pattern encompasses medial and lateral temporal structures, among which greater DV frequency is associated with more negatively correlated grey matter. Using a meta-analytic method of co-activation mapping, we demonstrate a higher probability of functional interactions among brain structures constituting the former pattern, particularly during memory-related processes. Our findings suggest that altered neural signalling within memory-related medial temporal brain structures underlies both pathological and non-pathological DV.

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Section: Introductionmentioning

confidence: 91%

Structural covariance mapping delineates medial and medio-lateral temporal networks in déjà vu

Shaw

Mareček

Brázdil

2015

Brain Imaging and Behavior

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“…This hypothesis derives from a work studying TLE. It has been shown that the déjà vu experiences of people with and without TLE are phenomenologically similar [85]. This account of déjà vu resonates with historical views of its relation with memory retrieval and consciousness in the temporal lobe (e.g., [87]).…”

Section: The Not-so-strange Sensation Of Déjà Vu In Epilepsymentioning

confidence: 50%

“…This feeling is perhaps more frequent in temporal lobe epilepsy (TLE) where it is reported as an ictal symptom (for review, see [84]). In fact, although patients with TLE who experience déjà vu may do so many times a month [85], the proportion who experience déjà vu is smaller than the proportion of people without epilepsy who experience it (controls 76.1%, TLE 63.1%) [86].…”

Section: The Not-so-strange Sensation Of Déjà Vu In Epilepsymentioning

confidence: 99%

“…In TLE, déjà vu is likely to be associated with headache, gustatory sensations, emotional states, and depersonalization and derealization. Warren-Gash and Zeman [85] (p.147) report one description: "At work I was on the phone and a colleague asked 'are you ok?' The conversation seemed familiar; I felt warm and had a metallic taste in my mouth.…”

Section: The Not-so-strange Sensation Of Déjà Vu In Epilepsymentioning

confidence: 99%

“…If déjà vu per se is the same in TLE, what clinical features that are associated with it are of relevance? Warren-Gash and Zeman [85] neatly summarized this issue by discussing déjà vu and 'the company it keeps'. We have developed this idea in Fig.…”

Section: The Not-so-strange Sensation Of Déjà Vu In Epilepsymentioning

confidence: 99%

See 2 more Smart Citations

Third International Congress on Epilepsy, Brain, and Mind: Part 2

Rektor¹,

Schachter²,

Arya³

et al. 2015

Epilepsy & Behavior

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*Corresponding author at: 165 Cambridge Street, Suite 702, Boston, MA 02114, USA. Tel.: +1 617 643 3835. sschacht@bidmc.harvard.edu (S.C. Schachter). Conflict of interestNone of the authors have any conflicts of interest to disclose. HHS Public Access Author Manuscript Author ManuscriptAuthor Manuscript Author ManuscriptEpilepsyis both a disease of the brain and the mind. Here, we present the first of two papers with extended summaries of selected presentations of the Third International Congress on Epilepsy, Brain and Mind (April 3-5, 2014; Brno, Czech Republic). Epilepsy in history and the arts and its relationships with religion were discussed, as were overviews of epilepsy and relevant aspects of social cognition, handedness, accelerated forgetting and autobiographical amnesia, and large-scale brain networks.

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