1990
DOI: 10.1017/s0033291700036424
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Is there immune dysfunction in depressive disorders?

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Cited by 29 publications
(10 citation statements)
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“…These conflicting results could be related to differences in methodology, species studied and clinical status. We speculate that the lack of response in our study was due to the fact that the cells examined were obtained from healthy individuals, supposedly without alterations in the 5HT transporters (Hickie et al, 1990;Cruess et al, 2005). It is worth to be mentioned that even in depressed patients the paroxetine may have no immunological effects if it is not paralleled by clinical Paroxetine and bupropion: effect on the proliferation of the lynphocytes Artigo originAL changes.…”
Section: Discussionmentioning
confidence: 78%
“…These conflicting results could be related to differences in methodology, species studied and clinical status. We speculate that the lack of response in our study was due to the fact that the cells examined were obtained from healthy individuals, supposedly without alterations in the 5HT transporters (Hickie et al, 1990;Cruess et al, 2005). It is worth to be mentioned that even in depressed patients the paroxetine may have no immunological effects if it is not paralleled by clinical Paroxetine and bupropion: effect on the proliferation of the lynphocytes Artigo originAL changes.…”
Section: Discussionmentioning
confidence: 78%
“…However, Pariante and Miller [23] reported that treatment of depressed outpatients with an antidepressant did not result in enhanced NKCA, but rather in decreases in NKCA from baseline to follow-up. As Hickie et al [24] point out, discrepant reports regarding an association between antidepressant treatment and augmented NKCA may be due to divergent patient samples drawn from outpatient versus inpatient populations. Outpatient samples may display milder forms of depressive illness without compromised NKCA, whereas inpatient samples may be skewed towards severe depressive illness with concomitant decrements in NKCA.…”
Section: Introductionmentioning
confidence: 99%
“…Others have not been able to confirm such observations (Schleifer et al, 1989). Furthermore, the clinical significance of rather small alterations in quantitative or qualitative immune measures is disputed (Hickie et al, 1990). Several authors have emphasized the need for prospective studies where psychological and immunological data are recorded simultaneously and related to clinical conditions (Schulz and Shulz, 1992;Stein et al, 1991;Bellinger et al, 1994).…”
Section: Introductionmentioning
confidence: 99%