Is trypanocidal drug resistance a threat for livestock health and production in endemic areas? Food for thoughts from Sahelian goats infected by Trypanosoma vivax in Bobo Dioulasso (Burkina Faso)

Vitouley, H.; Sidibé, Issa; Bengaly, Zakaria; Marcotty, Tanguy; Abbeele, Jan Van Den; Delespaux, V.

doi:10.1016/j.vetpar.2012.07.015

Cited by 17 publications

(15 citation statements)

References 22 publications

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“…Even if DA resistance is present, the effect of treatment on the PCV is still observable. This phenomenon was previously observed in cattle and goats inoculated with drug resistant trypanosomes and treated with trypanocidal drugs (Delespaux et al, 2010;Vitouley et al, 2012).…”

Section: Longitudinal Studysupporting

confidence: 69%

PCR and microsatellite analysis of diminazene aceturate resistance of bovine trypanosomes correlated to knowledge, attitude and practice of livestock keepers in South-Western Ethiopia

et al. 2015

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Section: Longitudinal Studysupporting

confidence: 69%

PCR and microsatellite analysis of diminazene aceturate resistance of bovine trypanosomes correlated to knowledge, attitude and practice of livestock keepers in South-Western Ethiopia

et al. 2015

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“…Available data, in 2001, indicated that resistance to isometamidium was more widespread than resistance to diminazene (Geerts et al 2001), however, this may no longer be so, as prevalence of resistance may change substantially over a few years (Delespaux et al 2008 a ). Treatment failure against T. congolense and T. vivax infections with either of these drugs has been observed in both West (Kupper and Wolters, 1983; Pinder and Authie, 1984; Knoppe et al 2006; Mungube et al 2012; Vitouley et al 2012) and East Africa (Mbwambo et al 1988; Chitambo and Arakawa, 1992 a ; Dagnachew et al 2015; Moti et al 2015). More worryingly, strains of T. congolense resistant to both isometamidium and diminazene have been detected in several locations, including Cameroon (Mamoudou et al 2008), Burkina Faso (Clausen et al 1992), Ethiopia (Codjia et al 1993; Afewerk et al 2000; Moti et al 2012), Somalia (Ainanshe et al 1992) and Zambia (Sinyangwe et al 2004), rendering their use as a sanative pair inoperative.…”

Section: Drug Resistance In the Field: Definition And Extent Of The Pmentioning

confidence: 99%

The animal trypanosomiases and their chemotherapy: a review

et al. 2016

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SUMMARYPathogenic animal trypanosomes affecting livestock have represented a major constraint to agricultural development in Africa for centuries, and their negative economic impact is increasing in South America and Asia. Chemotherapy and chemoprophylaxis represent the main means of control. However, research into new trypanocides has remained inadequate for decades, leading to a situation where the few compounds available are losing efficacy due to the emergence of drug-resistant parasites. In this review, we provide a comprehensive overview of the current options available for the treatment and prophylaxis of the animal trypanosomiases, with a special focus on the problem of resistance. The key issues surrounding the main economically important animal trypanosome species and the diseases they cause are also presented. As new investment becomes available to develop improved tools to control the animal trypanosomiases, we stress that efforts should be directed towards a better understanding of the biology of the relevant parasite species and strains, to identify new drug targets and interrogate resistance mechanisms.

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“…There is increasing evidence that the efficacy of chemotherapy is becoming reduced by the widespread development of trypanosome drug resistance in various parts on the country (Van den Bossche et al, 2000;Delespaux et al, 2008). Recent reports confirmed that diminazene aceturate and isometamidium chloride resistance in T. vivax and T. congolense in West Africa was observed (Sow et al, 2012;Vitouley et al, 2012). Even in Ethiopia the existence of drug resistant trypanosomes has also been reported by several authors (Mulugeta et al, 1997;Afework et al, 2000;Tewelde et al, 2004;Shimelis et al, 2008;Dagnachew et al, 2014).…”

Section: Resultsmentioning

confidence: 86%

“…The comparisons of trypanosome incidence and recurrence infection in south west Ethiopia showed drug resistant trypanosomes against diminazen aceturate (Rowland's et al, 2001). Vitouley et al (2012) indicated that under dosing, irregular use of prophylactics and discontinuation while at risk time and high incidence of trypanosomes are the root cause of development of drug resistance. Similarly, various scholars in Ethiopia have reported appearance of drug resistant trypanosomes in the Country (Mulugeta et al, 1997;Afework et al, 2000;Tewelde et al, 2004;Shimelis et al, 2008).…”

Section: Resultsmentioning

confidence: 99%

“…The present study showed that treatment with isometamidium to control trypanosome have developed resistance with the recommended dose of (1mg/kg of body weight). This might be due to higher frequency of treatment, under dosage and mishandling especially when the drugs are administered by farmers and possible occurrence of poor quality drugs on the market could be reasons for the development of resistance (Vitouley et al, 2012).…”

Section: Resultsmentioning

confidence: 99%

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Assessment of Trypanocidal Drug Resistance In Tsetse Infested Areas of Guraferda District, Bench Maji Zone, South Western Ethiopia

Tadele¹,

Teklemariam²,

Abera³

et al. 2019

Int. J. Agr. Ext.

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The South Western region of Ethiopia is affected by both tsetse and non-tsetse transmitted trypanosomosis with a significant impact on livestock productivity. The control of trypanosomosis in Ethiopia relies on either curative or prophylactic treatment of animals with diminazene aceturate (DA) or isometamidium chloride (ISMM). This study was conducted from March - June 2017, where tsetse infestation was high in four purposively selected rural kebeles of Guraferda district of Bench Maji Zone, South Western Ethiopia. The main objective of this study was to assess trypanocidal drug resistance under natural grazing systems. Resistance to trypanocidal drug was determined through longitudinal studies. In this study 200 cattle were used for experiment; 50 cattle from each rural kebeles (25 treated and 25 control group). However, 16 animals 5 from control and 11 from threated group were left due to sale of the animals by the owners, refusal of owners to allow their animals during sample collection and inability to reach the study kebeles because of heavy rain and presence of mud. In the present study, 25 cattle were treated with isometamidium and 25 cattle were left untreated and examined regularly at two weeks interval for the presence of trypanosomes. During the experimental period, all infections were monitored in both groups and treated with diminazene (7 mg/kg) body weight. Resistance to isometamidium was assessed by comparing cumulative incidence in both treated and control group using the test relative risk reduction and deducting the rate of treatment failure. Resistance to diminizene was assessed through the rate of treatment failure observed at two week post treatment in the control group. In both cases the threshold of 25% treatment failure was adopted as criteria of presence of chemo-resistance. The present study revealed that the prevalence of trypanosome infection was (76.8%) in control and (23.2%) in treated group. The trypanosome species in the area was predominantly due to T.Congolense (76.8%). This indicates there was a resistance of trypanosome species for the treatment with the recommended dose of diaminazine (7mg/kg) and isometamidium (1mg/kg) body weight. Thus, it is crucial to develop an adequate prophylactic measurements to reduce the prevalence of trypanosome infection there by reducing tsetse fly populations in the study areas.

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Is trypanocidal drug resistance a threat for livestock health and production in endemic areas? Food for thoughts from Sahelian goats infected by Trypanosoma vivax in Bobo Dioulasso (Burkina Faso)

Cited by 17 publications

References 22 publications

PCR and microsatellite analysis of diminazene aceturate resistance of bovine trypanosomes correlated to knowledge, attitude and practice of livestock keepers in South-Western Ethiopia

PCR and microsatellite analysis of diminazene aceturate resistance of bovine trypanosomes correlated to knowledge, attitude and practice of livestock keepers in South-Western Ethiopia

The animal trypanosomiases and their chemotherapy: a review

Assessment of Trypanocidal Drug Resistance In Tsetse Infested Areas of Guraferda District, Bench Maji Zone, South Western Ethiopia

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