Is type 2 diabetes mellitus associated with alterations in hearing? A systematic review and meta‐analysis

Akinpelu, Olubunmi V.; Mujica‐Mota, Mario A.; Daniel, Sam J.

doi:10.1002/lary.24354

Cited by 121 publications

(112 citation statements)

References 66 publications

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“…When comparing previous NL-SH results on hearing and comorbid conditions [Stam et al, 2014] with the current results, the present findings confirm the association between hearing impairment and diabetes. The data seem to further strengthen the evidence that exists for the association between hearing loss and diabetes as outlined in two recently published review studies [Horikawa et al, 2013;Akinpelu et al, 2014]. In these two review studies it was suggested that in patients with diabetes histological changes occur in the basilar membrane and stria vascularis leading to hearing loss.…”

Section: Main Findings and Previous Researchsupporting

confidence: 57%

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Medication Use in Adults with and without Hearing Impairment

Stam¹,

Spooren²,

Merkus³

et al. 2015

Audiol Neurotol

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The objective of this study was to determine whether hearing ability in adults is associated with medication use in general, the use of specific types of medication, or polypharmacy. In this exploratory study, data of the National Longitudinal Study on Hearing (NL-SH; n = 2,160) were used. In total, 62% of the participants reported using any medication in the past 28 days. Hearing ability in noise, as determined with an online digit-triplet speech-in-noise test, was significantly associated with (1) medication acting on the alimentary tract and metabolism (including diabetes and acid-related disorders), (2) use of calcium blockers, and (3) medication used for sensory organs.

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Section: Main Findings and Previous Researchsupporting

confidence: 57%

“…Relationships are reported between reduced hearing and diabetes [Horikawa et al, 2013;Akinpelu et al, 2014], cardiovas-nantly focused on the potential ototoxic effects of medication on hearing. It is known that several types of medicines can damage the inner ear temporarily or permanently [Van Eyken et al, 2007].…”

Section: Introductionmentioning

confidence: 99%

Medication Use in Adults with and without Hearing Impairment

Stam¹,

Spooren²,

Merkus³

et al. 2015

Audiol Neurotol

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“…However, studies exploring the direct association between atherogenic risk factors and hearing loss show inconsistent findings: dyslipidemia in terms of elevated levels of total cholesterol, low-density lipoprotein (LDL), triglycerides (TG) and low levels of high-density lipoprotein (HDL) have shown mainly adverse effects on hearing ability [Gates et al, 1993;Suzuki et al, 2000;Shargorodsky et al, 2010] but a gainful effect of high total cholesterol level has also been reported [Jones and Davis, 2000]. A relation between hearing ability and diabetes-related measures has been reported in several studies [Austin et al, 2009;Jang et al, 2011;Akinpelu et al, 2014], which is also the case for smoking [Fransen et al, 2008;Shargorodsky et al, 2010] and high BMI [Fransen et al, 2008;Lalwani et al, 2013]. Other studies, however, have shown conflicting results for these factors [Gates et al, 1993;Shargorodsky et al, 2010].…”

Section: Introductionmentioning

confidence: 99%

Atherogenic Risk Factors and Hearing Thresholds

et al. 2014

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The objective of this study was to evaluate the influence of atherogenic risk factors on hearing thresholds.In across-sectional study we analyzed data from a Danish survey in 2009-2010 on physical and psychological working conditions. The study included 576 white- and blue-collar workers from children's day care units, financial services and 10 manufacturing trades. Associations between atherogenic risk factors (blood lipids, glycosylated hemoglobin, smoking habits, body mass index (BMI), and ambulatory blood pressure) and hearing thresholds were analyzed using multiple linear regression models. Adjusted results suggested associations between smoking, high BMI and triglyceride level and low high-density lipoprotein level and increased low-frequency hearing thresholds (average of pure-tone hearing thresholds at 0.25, 0.5 and 1 kHz). Furthermore, an increasing load of atherogenic risk factors seemed associated with increased low-frequency hearing thresholds, but only at a borderline level of statistical significance. Associations were generally strongest with hearing levels of the worst hearing ear. We found no statistically significant associations between atherogenic risk factors and high-frequency hearing thresholds (average of pure-tone hearing thresholds at 4, 6 and 8 kHz).

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“…More recent population-based epidemiological studies (e.g., Bainbridge, Cheng, & Cowie, 2010;Bainbridge, Hoffman, & Cowie, 2008;Dalton, Cruickshanks, Klein, Klein, & Wiley, 1998) and systematic reviews or meta-analyses (Akinpelu, Mujica-Mota, & Daniel, 2014;Horikawa et al, 2013) support increased prevalence and incidence of hearing loss among adults with type 2 diabetes, although the strength of this association tended to weaken with advancing age. The systematic review and meta-analysis by Akinpelu et al (2014) also observed prolonged auditory brainstem response Wave V latencies among diabetics, suggesting an impact on higher level auditory processing. Konrad-Martin et al (2016), in a study of 222 older veterans, about half with type 2 diabetes and half without, found significantly longer latencies for cortical auditory evoked potentials, especially the P2 component.…”

mentioning

confidence: 99%

A Retrospective Examination of the Effect of Diabetes on Sensory Processing in Older Adults

Humes

2016

Am J Audiol

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Purpose: The purpose of this article is to examine retrospectively the impact of diabetes mellitus on auditory, visual, and tactile processing in older adults. Method: Fourteen (10.4%) of a sample of 135 older adults self-reported the presence of diabetes mellitus in a study of sensory and cognitive processing across the adult lifespan. In this study, the performance of the subgroup with diabetes on a number of psychophysical sensoryprocessing measures was compared with that of the 121 older adults without diabetes. Measures of sensory processing focused on temporal processing and threshold sensitivity in each of 3 sensory modalities: hearing, vision, and touch. Results: The subgroup of older adults with diabetes differed significantly (p < .05) from the larger group without diabetes only for measures of auditory temporal-order and temporal-masking identification tasks. Conclusion: This retrospective study provides additional evidence in support of higher level auditory-processing deficits in older adults with a positive history of diabetes mellitus.

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Is type 2 diabetes mellitus associated with alterations in hearing? A systematic review and meta‐analysis

Cited by 121 publications

References 66 publications

Medication Use in Adults with and without Hearing Impairment

Medication Use in Adults with and without Hearing Impairment

Atherogenic Risk Factors and Hearing Thresholds

A Retrospective Examination of the Effect of Diabetes on Sensory Processing in Older Adults

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