Is Varicella-Zoster Virus Involved in the Etiopathogeny of Pityriasis Lichenoides?

Boralévi, F.; Cotto, Emmanuelle; Baysse, Laurence; Jouvencel, Anne-Christine; Léauté‐Labrèze, Christine; Taı̈eb, Alain

doi:10.1046/j.1523-1747.2003.12357.x

Cited by 20 publications

(24 citation statements)

References 4 publications

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“…Lymphoproliferation in PL may be either interpreted as an antigen-driven or an autonomous process, because persistence of viral antigens has been shown in PL lesions. 8,10 We propose that PL represents a misguided benign proliferation of skin-homing cytotoxic T cells. The existence of a malignant variant (CxCTL) of this type of immunoproliferative disorder, which is also characterized by a strong expression of the antiviral protein MxA, supports this view.…”

Section: Discussionmentioning

confidence: 99%

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The role of cytotoxic skin-homing CD8+ lymphocytes in cutaneous cytotoxic T-cell lymphoma and pityriasis lichenoides

Wenzel¹,

Gütgemann

Distelmaier³

et al. 2005

Journal of the American Academy of Dermatology

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Section: Discussionmentioning

confidence: 99%

“…9 Other studies suggest that PL may represent a benign proliferative disorder stimulated by viral antigens. 8,10 Here we report the case of a patient presenting with a picture resembling PLEVA that turned to malignant CxCTL. The inflammatory infiltrate was characterized by immunohistochemistry with several monoclonal antibodies.…”

mentioning

confidence: 98%

The role of cytotoxic skin-homing CD8+ lymphocytes in cutaneous cytotoxic T-cell lymphoma and pityriasis lichenoides

Wenzel¹,

Gütgemann

Distelmaier³

et al. 2005

Journal of the American Academy of Dermatology

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“…In 2003 Boralevi et al investigated the presence of varicella zoster virus in 13 patients with histologically confirmed pityriasis lichenoides, as well as in 22 control subjects. 79 Twelve of the 13 pityriasis lichenoides patients and 19 of 22 control subjects had a history of chickenpox. PCR methods were used to identify genomic sequences of varicella zoster virus in skin samples from 8 of the 13 pityriasis lichenoides patients (61.5%) and none of the control subjects (P \ .0001).…”

Section: Infectious Etiologymentioning

confidence: 99%

Pityriasis lichenoides and its subtypes

Bowers

Warshaw

2006

Journal of the American Academy of Dermatology

201

284

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“…Boralevi et al . carried out an open trial on 12 patients with PL lasting from a mean of 6 months and treated with acyclovir or valaciclovir.…”

Section: Resultsmentioning

confidence: 99%

A systematic review of treatments for pityriasis lichenoides

Bellinato

Maurelli

Gisondi

et al. 2019

Acad Dermatol Venereol

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Pityriasis lichenoides (PL) represents a spectrum of inflammatory skin diseases comprising pityriasis lichenoides et varioliformis acuta (PLEVA) and pityriasis lichenoides chronica (PLC). This study aimed to provide a summary of effective treatments for PL. A systematic review was performed according to PRISMA guidelines for studies investigating PL treatment including ≥3 subjects and published in English between 1 January 1970 and 15 April 2019. A total of 441 papers were screened, and 37 original manuscripts meeting the inclusion and exclusion criteria were found, including 12 case series, 18 reviews, four prospective studies, two comparative studies and a single randomized controlled study. In most studies, ultraviolet (UV) phototherapy (narrow‐band UVB, broadband UVB, UVA1 or PUVA) was used. Clearance rates with the different modalities are hardly comparable between different studies, ranging approximately between 70% and 100%. Narrow‐band UVB showed an efficacy similar to PUVA as such as the combination of UVA and UVB vs. PUVA. Oral erythromycin showed clearance rates ranging between 66% and 83%, whereas methotrexate up to 100% but in small and dated studies. Evidence for other treatments is scarce. There is a lack of high level of evidence studies on PL treatment. The interpretation of the results is biased by the possible auto‐resolution of the disease, the sample heterogeneity between children and adults and the short follow‐up period of the studies. Only some studies investigated how results were durable after cessation of therapy. Quality of life and the impact of treatment were never assessed. According to the results of this review, we suggest narrow‐band UVB phototherapy as first‐line treatment. Oral erythromycin with or without topical corticosteroids and low‐dose methotrexate as second‐line therapies. High‐powered studies and randomized controlled trials are needed to establish the optimal treatment for PL.

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Is Varicella-Zoster Virus Involved in the Etiopathogeny of Pityriasis Lichenoides?

Cited by 20 publications

References 4 publications

The role of cytotoxic skin-homing CD8+ lymphocytes in cutaneous cytotoxic T-cell lymphoma and pityriasis lichenoides

The role of cytotoxic skin-homing CD8+ lymphocytes in cutaneous cytotoxic T-cell lymphoma and pityriasis lichenoides

Pityriasis lichenoides and its subtypes

A systematic review of treatments for pityriasis lichenoides

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