Is Vitamin D Deficiency a Risk Factor for the Development of Statin-Induced Myalgia in Patients Receiving Statins?

The association between vitamin D concentration and pain: a systematic review and meta-analysis

“…According to the Newcastle–Ottawa scale, sixty-two of the eighty-one observational studies were very good or good quality ( 33 – 35 , 37 , 39 – 43 , 45 , 48 , 49 , 51 , 54 – 57 , 59 , 60 , 62 , 64 – 70 , 72 – 74 , 76 – 82 , 84 , 86 – 100 , 102 – 108 ) , sixteen were satisfactory ( 31 , 44 , 46 , 47 , 50 , 52 , 53 , 58 , 61 , 63 , 71 , 75 , 83 , 85 , 101 ) and the remaining three were unsatisfactory ( 32 , 36 , 38 ) . Specifically, the quality for cross-sectional studies was good for twelve, satisfactory for four and unsatisfactory for three; for case–control studies, nine were very good, thirty-five were good and twelve were satisfactory; and for cohort studies, three were very good and three good.…”

“…For the primary aim, seventy-three studies, containing 13 294 participants with pain and 21 078 without pain conditions, reported serum 25(OH)D levels ( 32 , 34 – 40 , 42 – 45 , 47 – 50 , 52 – 75 , 77 – 102 , 104 – 108 ) . Two publications reported the vitamin D concentration and pain conditions on different subgroups (smokers and non-smokers ( 39 ) or Italian and Estonian ( 53 ) ), which are reported separately as four different studies in the current meta-analysis (Supplement 2, Supplemental Table 2).…”

“…The eighty-one observational studies involved nineteen cross-sectional studies (31)(32)(33)(34)(35)(36)(37)(38)(39)(40)(41)(42)(43)(44)(45)(46)(47)(48) , fifty-six case-control studies and six cohort studies (103)(104)(105)(106)(107)(108) . Together, these studies included 50 834 participants, 21 723 of whom were reported as pain subjects, with a median mean age of 49•4 (median SD 10•3) years and median female proportion of 80•5 % (range: 0-100 %); and 29 111 participants who were community-or hospital-based controls without pain-related conditions, with a median mean age of 50•0 (median SD 10•3) years and median female proportion of 78•4 % (range: 0-100 %).…”

The role of vitamin D in statin treated patients complaining of myalagia

“…3). 14,15 Muscle cells have vitamin D receptors. It was found that >30 various tissues including skeletal muscle tissue express vitamin D receptors (VDR).…”