Ischaemia modified albumin cannot be used for rapid exclusion of acute coronary syndrome

Abstract

This study does not support the use of IMA as a negative predictor for ACS.

Serum and Saliva Levels of Ischemia‐Modified Albumin in Patients with Acute Myocardial Infarction

“…This method has been developed to determine IMA in the setting of cardiac ischemia, which could improve the sensitivity of diagnosing ACS. Although some studies supported the use of IMA in patients presenting symptoms of ACS (12,(23)(24)(25), the others did not support the use of IMA alone in the diagnosis of ACS or AMI (26)(27)(28)(29)(30). IMA levels in our study are consistent with some previous reports, that serum IMA levels of patients with AMI were significantly higher than those of healthy subjects.…”

Combinatorial Determination of Ischemia Modified Albumin and Protein Carbonyl in the Diagnosis of NonST-Elevation Myocardial Infarction

“…However, the area under curve of ROC curve of IMA was not good enough and might not be a good candidate for diagnosis of myocardial infarction. The lack of diagnostic potential of IMA was also mentioned in many studies [1,21,22]. However, our results showed that combinatorial determination of these two biomarkers gave not good enough for NSTEMI diagnosis as it, although it slightly increased NPV and test efficiency.…”

Pregnancy-associated plasma protein A and procalcitonin as markers of myocardial injury in patients with acute coronary syndrome

“…This suggests that IMA levels may not be useful as a diagnostic indicator in the differential diagnosis of acute coronary syndrome in the emergency department. Previous studies reported that IMA had good accuracy (66% to 95%) but low specificity (13% to 45%) for the diagnosis of patients with acute coronary syndrome (16)(17)(18), although IMA may not be used to reliably exclude the diagnosis of acute coronary syndrome in the emergency department (19,20). IMA may be a guide as to whether to perform further investigation for acute coronary syndrome in patients admitted to the emergency department with chest pain, analogous to D-dimer testing in the diagnostic algorithm for pulmonary embolism (21,22).…”