Ischemia modified albumin, high-sensitivity c-reactive protein and natriuretic peptide in patients with coronary atherosclerosis

Kazanis, K.; Nounopoulos, C.; Manolis, Antonis S.; Sakellaris, Nikolaos; Jullien, G; Dionyssiou-Asteriou, Amalia

doi:10.1016/j.cca.2009.07.007

Cited by 32 publications

(21 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…It is also increased in diabetes mellitus, hyperlipidemia, chronic renal disease and obesity [17][18][19][20]. The constriction of vessels due to atherosclerotic lesions causes hypoxia/ischemia and oxidative changes resulting in transformation of free albumin to IMA in the circulation [21,22]. Recently, increased levels of IMA have been reported in patients with β-TM [11].…”

Section: Introductionmentioning

confidence: 99%

Ischemia-modified albumin as a marker of vascular dysfunction and subclinical atherosclerosis in β-thalassemia major

et al. 2017

View full text Add to dashboard Cite

Background: Ischemia-modified albumin (IMA) is an altered type of serum albumin that forms under conditions of oxidative stress and an independent predictor of major adverse cardiovascular events. Objectives: To measure the levels of IMA in 45 children and adolescents with β-thalassemia major (β-TM) compared with 30 healthy controls and assess its relation to lipid peroxidation, vascular complications and subclinical atherosclerosis. Methods: β-TM patients without symptoms of heart disease were studied focusing on transfusion history, chelation therapy, serum ferritin, malondialdehyde (MDA) and IMA levels. Echocardiography was performed and carotid intima media thickness (CIMT) was assessed. Results: IMA and MDA levels were significantly higher in β-TM patients compared with controls (p < 0.001). IMA was higher among patients with heart disease, pulmonary hypertension risk and serum ferritin ≥2500 µg/l than those without. TM patients compliant to chelation had significantly lower IMA levels. IMA levels were positively correlated to MDA and CIMT while negatively correlated to ejection fraction and fractional shortening. Conclusion: Our results highlight the role of oxidative stress in the pathophysiology of vascular complications in thalassemia. IMA could be useful for screening of β-TM patients at risk of cardiopulmonary complications and atherosclerosis because its alteration occurs in early subclinical disease.

show abstract

Section: Introductionmentioning

confidence: 99%

Ischemia-modified albumin as a marker of vascular dysfunction and subclinical atherosclerosis in β-thalassemia major

et al. 2017

View full text Add to dashboard Cite

show abstract

“…Multivessel CAD disease is associated with an increase in mortality, and IMA can be used indirectly as a mortality indicator. In addition, a study conducted in 2009 showed that the IMA level may serve as an indicator of atherosclerotic disease burden before hsCRP and pro-B-type natriuretic peptide elevation, thereby holding promise as a risk classification factor [29]. Other studies have indicated a possible role for IMA testing in the early triage of patients with chest pain [30,31].…”

Section: Discussionmentioning

confidence: 99%

The relationship between ischaemia-modified albumin and good coronary collateral circulation

Gök¹,

Kundi²,

Kızıltunç³

et al. 2018

Kardiol Pol

View full text Add to dashboard Cite

A b s t r a c t Background:It is important to determine the grade of the coronary collateral circulation (CCC) in patients with stable coronary artery disease. Aim:In this study, we aimed to investigate the relationship between the ischaemia-modified albumin (IMA) level and good CCC. Methods:A total of 95 patients with coronary angiography and at least one epicardial coronary artery obstruction were included in the study. The Rentrop classification was used with CCC grading, where 0 and 1 were defined as poor collateral, and 2 and 3 were defined as good collateral. The IMA level of the patients was measured using an enzyme-linked immunosorbent assay (ELISA). The receiver-operating characteristic curve was used to show the sensitivity and specificity of IMA levels and the optimal cut-off value for predicting good CCC. Results:The multiple logistic regression analysis revealed that the IMA level in the good CCC group was higher (p < 0.045). Conversely, the high-sensitivity C-reactive protein level was lower in the good CCC group (p < 0.023). We found an IMA cut-off value (4.7 ng/mL) that indicated good CCC level, and this shows good CCC with 70.2% sensitivity and 60.3% specificity. Conclusions:The IMA level could serve as a simple and useful predictor of well-developed CCC.

show abstract

“…6 IMA is formed as a consequence of modification of albumin by reactive oxygen species (ROS). 7 A decrease in blood flow is believed to trigger ROS formation, which consequently modify the N-terminal portion of albumin leading to IMA formation. 8 The aggravated production of toxic oxygen radicals and related compounds has been noted in HD patients and patient with HCV infection and there is evidence of modification of albumin by both acute and chronic oxidative stress.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Ischemia Modified Albumin in Hepatitis C Positive Hemodialysis Patients : A Pilot Study

Kumar

Suchitra

et al. 2012

Int J of Biomed & Adv Res

View full text Add to dashboard Cite

Background: Chronic hemodialysis (HD) patients are more prone for infection such as Hepatitis C virus (HCV) infection, which may be associated with increased oxidative stress (OS). Ischemiamodified albumin (IMA) levels rises not only during ischemia but also during chronic OS. Hence the study was aimed to evaluate the levels of IMA and its association with oxidative stress in HCV positive HD patients. Methods: Twenty two HCV positive [HCV (+)], 22 HCV negative [HCV (-)] patients with end stage renal disease (ESRD) on maintenance HD and 22 healthy subjects were enrolled in this crosssectional observational study. Plasma IMA was determined by spectrophotometric Co (II) -albumin binding assay. Plasma MDA was determined by spectrophotometric method. Results: Both MDA and IMA levels were significantly higher in HCV (+) and HCV (-) HD patients compared to controls (p < 0.001). A significant increase in MDA levels was observed in HCV (+) HD patients when compared with HCV (-) HD patients (p<0.001); however no change in IMA levels were noted between HCV (+) and HCV (-) HD patients. A negative correlation was observed between IMA and MDA levels in both HCV (+) (r= -0.278, p=0.178) and HCV (-) HD patients (r= -0.193, p=0.354) which were however not statistically significant. Conclusion: Plasma IMA and MDA levels were elevated in both groups of HD patients when compared to controls. However, hepatitis C infection does not appear to cause any additional increase of IMA levels in HD patients.

show abstract

Ischemia modified albumin, high-sensitivity c-reactive protein and natriuretic peptide in patients with coronary atherosclerosis

Cited by 32 publications

References 30 publications

Ischemia-modified albumin as a marker of vascular dysfunction and subclinical atherosclerosis in β-thalassemia major

Ischemia-modified albumin as a marker of vascular dysfunction and subclinical atherosclerosis in β-thalassemia major

The relationship between ischaemia-modified albumin and good coronary collateral circulation

Evaluation of Ischemia Modified Albumin in Hepatitis C Positive Hemodialysis Patients : A Pilot Study

Contact Info

Product

Resources

About