Ischemia-modified albumin levels in children with asthma: a pilot study

Doğru, Mahmut; Akoğlu, Handan Ayhan; Kılınçkaya, Muhammed Fevzi; Ülfer, Gözde

doi:10.5546/aap.2018.eng.e522

Cited by 3 publications

(1 citation statement)

References 9 publications

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“…Kahveci et al also reported significantly higher IMA values in preterm babies with respiratory distress syndrome [ 11 ]. Furthermore, Doğru et al obtained IMA values significantly higher in children with asthma attack and stable asthma compared to the control group, and IMA values were significantly higher in the patient group than the control group [ 16 ]. Özyurt et al reported a significant correlation between both thiol and IMA and bronchiectasis patients [ 17 ].…”

Section: Discussionmentioning

confidence: 99%

Thiol/Disulfide Homeostasis and Ischemia-Modified Albumin Levels in 61 Patients with Hypercapnia: A Case-Control Study

et al. 2023

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Background Hypercapnia is abnormally high arterial partial pressure of carbon dioxide (CO 2 ). CO 2 can affect redox signaling mechanisms, leading to production of oxidative derivatives. Thiol is formed by attaching a sulfhydryl group to a carbon atom. Under oxidative stress, it forms covalent bonds called thiol disulphide bonds. Serum albumin is modified to ischemia-modified albumin (IMA) by exposure to free radicals. This case-control study aimed to evaluate thiol/disulphide homeostasis and IMA levels in 61 patients with hypercapnia. Material/Methods We studied 61 patients with hypercapnia and 61 normocapnic volunteers in the control group, between May 2018 and January 2019; 56 of these patients were diagnosed with chronic obstructive pulmonary disease and 5 of them were diagnosed with obstructive sleep apnea syndrome. Arterial blood samples analyzed by using the Ellman reagent for thiol/disulphide data. A colorometric assay was used for detection of IMA levels. Results Native thiol and total thiol values in the hypercapnic group were significantly lower than in the control group ( P =0.024, P =0.006 respectively), as IMA values were significantly higher ( P <0.001). There was no statistically significant difference between the hypercapnic and control groups in terms of disulphide, disulphide/native thiol, disulphide/total thiol, and native thiol/total thiol values ( P >0.05). Conclusions In hypercapnic patients, there are changes in thiol/disulphide homeostasis and IMA levels. All significant differences in this study support that changes in thiol disulphide homeostasis and IMA in hypercapnic patients are indicators of oxidative stress.

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Section: Discussionmentioning

confidence: 99%

Thiol/Disulfide Homeostasis and Ischemia-Modified Albumin Levels in 61 Patients with Hypercapnia: A Case-Control Study

et al. 2023

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Evaluation of Thiol/Disulfide Homeostasis in Bronchiectasis

Özyurt

Özçelik

Kara

et al. 2022

Canadian Respiratory Journal

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Purpose. Thiols are sulfhydryl-containing organic compounds that have an important role in preventing cellular oxidative stress. This study compares the blood oxidative stress marker levels in bronchiectasis cases during their stable periods with healthy controls. Materials and Methods. Seventy-seven patients (49 patients with stable bronchiectasis/28 healthy controls), followed up by the chest disease clinic, were included in the study. Peripheral blood thiol-disulfide parameters (NT: native thiol (−SH); TT: total thiol (−SH + SS); SS: disulfide (−SS); SS-SH: disulfide/native thiol index; SS-TT: disulphide/total thiol index; SH-TT: native thiol/total thiol index), and ischemia-modified albumin (IMA) levels were examined in the stable bronchiectasis group and the control group. Thiol-disulfide homeostasis was evaluated using a novel and automated assay. Findings and Result. Blood native thiol levels in patients with stable bronchiectasis were found to be significantly higher compared with healthy controls. A positive correlation between the total airway disease score and IMA levels was present. Our findings revealed that native thiol levels, which constitute a part of the antioxidant defense system, are increased in patients with stable bronchiectasis.

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The Evaluation of Ischemia Modified Albumin and Adropin Levels in Patients with Pulmonary Embolism

Erdem

Yücel

Gederet

et al. 2021

Journal of Basic and Clinical Health Sciences

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Pulmonary embolism (PE) is a serious clinical condition and difficult to be diagnosed. The aim of the present study was to evaluate plasma adropin and ischemia-modified albumin (IMA) levels in the patients with PE. Methods:The study consisted of 109 participants, including 50 patients with PE and 59 healthy individuals. The patients diagnosed with PE through computed tomography pulmonary angiography (CTPA) were included into the study. Plasma adropin and IMA concentrations were measured by an enzyme-linked immunosorbent assay kit. Results:The patients with PE had higher plasma adropin (607.5±205.1 ng/mL) and lower IMA (2128.6±801.8 ng/mL) levels, compared with those in the controls (505.5±231.3 ng/mL and 2466.9±1044.9 ng/mL, respectively); however, the difference was not significant. In the study, we found a weak and negative correlation between adropin and IMA levels in the patients with PE (p=0.020, r=-0.348). Conclusions:In our study among the patients with PE, there was no significant difference between adropin and IMA levels, although plasma atropin concentrations were high, and IMA concentrations were low. So, we consider that both IMA and adropin are inappropriate markers for the diagnosis of PE.

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Ischemia-modified albumin levels in children with asthma: a pilot study

Abstract: Asthmatic children had higher IMA levels than the control group, both in stable and exacerbated asthma. There was a positive relationship between IMA levels and severity of asthma exacerbation.

Cited by 3 publications

References 9 publications

Thiol/Disulfide Homeostasis and Ischemia-Modified Albumin Levels in 61 Patients with Hypercapnia: A Case-Control Study

Thiol/Disulfide Homeostasis and Ischemia-Modified Albumin Levels in 61 Patients with Hypercapnia: A Case-Control Study

Evaluation of Thiol/Disulfide Homeostasis in Bronchiectasis

The Evaluation of Ischemia Modified Albumin and Adropin Levels in Patients with Pulmonary Embolism

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