Ischemic anoxia and cerebral serotonin levels

Cathecholamine and 5-hydroxytryptamine levels in ischemic brain. Influence of p-chlorophenylalanine.

“…18 However, the exact cause of this reduction has not been directly identified. Previous reports from this laboratory in the baboon 2 and clinical patients with stroke, 8 as well as studies in the gerbil by Lavyne and colleagues," have suggested neuronal release of monoamines early after the onset of ischemia. Neuronal membrane depolarization with ionic shifts 18 as well as synaptosomal mitochondrial dysfunction, 19 conditions which might cause abnormal release of neurotransmitters, are well documented in cerebral ischemia.…”

Constriction of Pial Arterioles Produced by Prostaglandin F 2α

“…This is not the case, and in the present study, as well as the studies of other workers, each of these vasoactive agents is effective only in concentrations greater than those known to occur even during pathological conditions. 25 - 26 However, the concentration of these materials during pathological states is still relatively unexplored and for PG is virtually unknown with respect to the central nervous system and cerebrospinal fluid. Moreover, the sensitivity of pial vessels may be enhanced during periods of microcirculatory derangement.…”

Photochemically Induced Cortical Infarction in the Rat. 1. Time Course of Hemodynamic Consequences

“…Serotonin is known to be a potent cerebral vasoconstrictor (Raynor et al, 196 1;Karlsberg et al, 1963), and is released from aggregating platelets (Welch et al, 1972;Sam uelsson et al, 1976). Increased levels of serotonin within the cerebrospinal fluid of patients early after the onset of cerebral infarction have been docu mented (Meyer et al, 1974).…”