Ischemic Colitis Complicating Sickle Cell Crisis

Gage, Thomas P.; Gagnier, J. Michael

doi:10.1016/s0016-5085(83)80183-8

Cited by 52 publications

(18 citation statements)

References 11 publications

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“…4 5 To our knowledge, there is only one previous report of ischaemic colitis in adults complicating sickle cell disease. 3 In contrast to the previous report, our case manifested only minimal abdominal findings. The suspicion of acute surgical illness was raised by unexplained metabolic acidosis in the context of diminished bowel sounds and was subsequently supported by imaging studies and endoscopy.…”

Section: Discussioncontrasting

confidence: 97%

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Fulminant ischaemic colitis with atypical clinical features complicating sickle cell disease

Karim

Ahmed

Rossoff

et al. 2002

Postgraduate Medical Journal

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Clinically significant ischaemic bowel injury is an exceedingly rare complication of sickle cell disease. It manifests as acute surgical abdomen and may respond to conservative treatment. An unusual fatal case of ischaemic colitis with minimal abdominal findings in a young male during a sickle cell vaso-occlusive pain crisis is described. This case demonstrates that an acute surgical abdomen should be considered in such patients who fail to respond to conservative management as untreated this condition may be fatal.

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Section: Discussioncontrasting

confidence: 97%

“…Clinically significant ischaemic bowel injury is rare during sickle cell crisis. 3 Ischaemic colitis typically manifests as sudden onset abdominal pain, distension, and the detection of maroon blood in stool. 4 5 The diagnosis relies on a combination of clinical, radiographic, and endoscopic findings.…”

Section: Discussionmentioning

confidence: 99%

Fulminant ischaemic colitis with atypical clinical features complicating sickle cell disease

Karim

Ahmed

Rossoff

et al. 2002

Postgraduate Medical Journal

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“…SCD can involve multiple organ systems including the gastrointestinal tract. These gastrointestinal manifestations usually occur due to small vascular infarcts and microvascular occlusion and ischemia presenting as abdominal crisis with severe pain, acute pancreatitis, peptic ulcer disease and rarely ischemic bowel[ 6 , 7 ]. The hepatobiliary system is one of the most common intra-abdominal organs involved in SCD and hepatic involvement is observed in 10%-40% cases of sickle cell crisis[ 8 - 10 ].…”

Section: Hepatobiliary Manifestations Of Scdmentioning

confidence: 99%

Acute and chronic hepatobiliary manifestations of sickle cell disease: A review

Shah

Taborda

Chawla

2017

WJGP

102

117

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Sickle cell disease (SCD) is a common hemoglobinopathy which can affect multiple organ systems in the body. Within the digestive tract, the hepatobiliary system is most commonly affected in SCD. The manifestations range from benign hyperbilirubinemia to overt liver failure, with the spectrum of acute clinical presentations often referred to as “sickle cell hepatopathy”. This is an umbrella term referring to liver dysfunction and hyperbilirubinemia due to intrahepatic sickling process during SCD crisis leading to ischemia, sequestration and cholestasis. In this review, we detail the pathophysiology, clinical presentation and biochemical features of various acute and chronic hepatobiliary manifestations of SCD and present and evaluate existing evidence with regards to management of this disease process. We also discuss recent advances and controversies such as the role of liver transplantation in sickle cell hepatopathy and highlight important questions in this field which would require further research. Our aim with this review is to help increase the understanding, aid in early diagnosis and improve management of this important disease process.

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“…Antiphospholipid antibodies and Factor V Leiden mutations are found 10 times more frequently in patients with ischemic colitis. 16 When colonic ischemia is found in younger patients, there has been association with vasculitis, 17 drugs and medications, [18][19][20][21][22][23] sickle cell disease, 24 extreme exercise, 25,26 and even taking an airplane flight. 27 The right colon is more frequently involved for unknown reasons.…”

Section: Etiologymentioning

confidence: 99%

Management of Ischemic Colitis

Washington

Carmichael

2012

Clinics in Colon and Rectal Surgery

111

129

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Ischemic colitis is a commonly misunderstood clinical condition. Although the colon is the most common region of ischemia in the gastrointestinal tract, many surgeons have difficulty with diagnosis and treatment of ischemic colitis. The process can occur from either occlusive vascular disease or nonocclusive disease, and can be gangrenous or nongangrenous. Differentiating gangrenous from nongangrenous disease can be a difficult clinical challenge as both sets of patients generally present with abdominal pain and bloody diarrhea. Although the majority of patients have transient ischemia with nongangrenous colitis that can be successfully managed nonoperatively, prompt recognition and surgical intervention is critical in patients with gangrenous colitis. In this article, the diagnosis and treatment of ischemic colitis is reviewed with emphasis on a systematic, evidence-based approach to management.

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Ischemic Colitis Complicating Sickle Cell Crisis

Cited by 52 publications

References 11 publications

Fulminant ischaemic colitis with atypical clinical features complicating sickle cell disease

Fulminant ischaemic colitis with atypical clinical features complicating sickle cell disease

Acute and chronic hepatobiliary manifestations of sickle cell disease: A review

Management of Ischemic Colitis

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