Ischemic Colitis of the Left Colon in a Diabetic Patient

Karayiannakis, Anastasios J.; Bolanaki, Helen; Kouklakis, Georgios; Dimakis, Konstantinos; Memet, Ilker; Simopoulos, Constantinos

doi:10.1159/000327981

Cited by 6 publications

(4 citation statements)

References 19 publications

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“…Of all the risk factors for GC, the most prevalent was the presence of diabetes [ 9 ]. Patients with a history of diabetes can often have polyneuropathy, which may symptomatically mask lethal pathologies such as myocardial ischemia and ischemic colitis [ 10 , 11 ]. This phenomenon is suggested by the inability of motor and sensory nerves to transmit signals in the setting of diabetic polyneuropathy.…”

Section: Discussionmentioning

confidence: 99%

Occult Perforated Gangrenous Gallbladder Found on Magnetic Resonance Cholangiopancreatography

Parza

Patel

Scibelli

et al. 2021

Cureus

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Acute gangrenous cholecystitis is a life-threatening disease that is most often diagnosed intraoperatively and can be missed on mildly symptomatic patients without the proper imaging modality. We present a case of a 69-year-old male with a history of hypertension, hyperlipidemia, and type 2 diabetes, and a recent right pontine infarct that arrived with 3 out of 10 right-sided abdominal pain. His liver ultrasound and computed tomography (CT) with contrast demonstrated acute cholecystitis. He was initially worked up conservatively and was scheduled for an elective cholecystectomy per surgery recommendation. However erring on the side of caution, the medical team had ordered a magnetic resonance cholangiopancreatography (MRCP), which demonstrated perforated gangrenous cholecystitis. Of note, the imaging modalities were ordered within a 24-hour window. The patient’s antibiotics were promptly broadened, and he was emergently sent to the operating room. Moving forward, we will identify atypical clinical presentations of gangrenous cholecystitis and consider ordering an MRCP when clinical suspicion remains high and initial imaging is inconclusive. Perforated gangrenous cholecystitis is a severe disease and can cause rapid demise if not identified and treated early.

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Section: Discussionmentioning

confidence: 99%

Occult Perforated Gangrenous Gallbladder Found on Magnetic Resonance Cholangiopancreatography

Parza

Patel

Scibelli

et al. 2021

Cureus

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“…Although it may occur at any age, the risks have been found higher in the elderly [6]. In addition to its risk being increased with age, the prevalence of GI complications has also been reported to be higher in diabetic patients compared with non-diabetics, primarily as a result of diabetic autonomic neuropathy involving the GI tract [7]. The study at hand is the case of an elderly, male, diabetic patient who presented with gut gangrene and subsequently underwent intestinal resection.…”

Section: Discussionmentioning

confidence: 99%

Postoperative nutritional support of the patient with gut gangrene—a case report

Imran¹,

Tanweer

2019

J Health Popul Nutr

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Background Bowel necrosis is a commonly observed condition in elderly patients with longstanding diabetes. In such condition, intestinal resection is usually performed for the removal of the gangrenous part. Post-surgical dietary management after bowel resection poses several challenges for the health care team. Case presentation The case presented in this study is that of an elderly diabetic male who developed acute renal failure as a result of neglect in post-surgical feeding after intestinal resection. After the intervention by a trained dietitian, a transitional diet was planned and successfully executed, resulting in reversal of acute renal failure, dehydration, and post-surgical stress. Several complications including hepatic dysfunction and mouth ulcers were resolved through well-planned transitional diet. The patient was finally discharged in a stable health condition and was regularly followed up for any nutritional or medical issues. Conclusion Neglects in nutritional care of patients can have severe implications including development of medical complications, resulting in increased length of hospital stay, augmenting the disease stress of the patient and family, and finally the preventable drainage of several human and monetary resources. Therefore, recognition of nutritional intervention as an important part of in-hospital health care may have social as well as economic impacts.

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“…After preparation of the rats, they were anaesthetized as done by Shivkumar using 30 mg/kg, i.p thiopentone sodium [21]. The abdomen was opened and blood samples were collected directly from the heart by cardiac puncture.…”

Section: Collection Of Blood Samples For Analysismentioning

confidence: 99%

Modulations in Anti-Oxidant Activities of Selected Gastro-Intestinal Tissues in Alloxan-Induced, Silymarin Treated Diabetic Wistar Rats

Ataihire¹,

Nwangwa²,

Igweh³

2019

OJGas

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Diabetes mellitus (DM) is reportedly the commonest metabolic disorder with multi organ involvement. By inducing DM (with Alloxan) in Wistar rats, current study investigated the changes in antioxidant activities of selected gastrointestinal (GI) tissues [stomach, duodenum, pancreas and liver], upon treatment with Silymarin and/or Vitamin C. One hundred and twenty five (125) adult male wistar rats of between 130 to 180 grams were procured for the study. Five units of one control and four experimental units were designated with twenty five (25) rats per group (n = 25); Unit 1: Control rats, Unit 2 were DM induced, Silymarin untreated rats, and Units 3, 4 and 5 were DM induced, vitamin C, Silymarin and Vitamin C + Silymarin treated respectively. Following four (4) weeks of administration of test substance(s), rats were euthanized and blood samples obtained for biochemical and antioxidant assay on aforementioned GI tissues. One way analysis of variance (ANOVA) and Students t-test at p < 0.05 were set to be statistically significant on analysis of obtained data. First, study found DM to have caused a statistically significant decrease in body weight prior to sacrifice. Catalase (CAT), superoxide dismutase (SOD) and malonaldehyde (MDA) levels were also seen to significant increase (p < 0.05) at comparison of extract treated unit to control. Study also observed a significant change in pancreatic, liver, and duodenal anti-oxidant marker levels with Vitamin C, Silymarin and Vitamin C + Silymarin co-administrations to diabetic rats. It can therefore be said, that DM caused a destructive alteration pancreatic histo-architecture with improved functional capabilities in wistar rats at administration of Silymarin and vitamin C. Thus, Silymarin posed antioxidant potentials, with ameliorated pancreatic dysfunctions.

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Ischemic Colitis of the Left Colon in a Diabetic Patient

Cited by 6 publications

References 19 publications

Occult Perforated Gangrenous Gallbladder Found on Magnetic Resonance Cholangiopancreatography

Occult Perforated Gangrenous Gallbladder Found on Magnetic Resonance Cholangiopancreatography

Postoperative nutritional support of the patient with gut gangrene—a case report

Modulations in Anti-Oxidant Activities of Selected Gastro-Intestinal Tissues in Alloxan-Induced, Silymarin Treated Diabetic Wistar Rats

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