Ischemic heart disease in women and the role of hormone therapy

Raza, Jaffar Ali; Reinhart, Richard A.; Movahed, Assad

doi:10.1016/j.ijcard.2003.06.013

Cited by 19 publications

(10 citation statements)

References 191 publications

(126 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This is in contrast to recent randomized clinical trials, which have suggested that a combination of equine estrogens plus progestin do not confer cardiac protection and indeed may increase the risk of CAD [27].…”

Section: Introductioncontrasting

confidence: 92%

“…Numerous clinical observational, animal and cellular studies reported beneficial effects of estrogen on cardiovascular disease risk [27]. This is in contrast to recent randomized clinical trials, which have suggested that a combination of equine estrogens plus progestin do not confer cardiac protection and indeed may increase the risk of CAD [27].…”

Section: Introductionmentioning

confidence: 82%

“…These results are consistent with our working hypothesis that stipulated that genetic polymorphisms that have been shown to be associated with increased angiotensin II production or activity may potentially predispose postmenopausal women using HRT to ACS. However, the estrogen -CAD hypothesis has recently been challenged when randomized trials such as HERS and HERS2 demonstrated a lack of cardiovascular protection and even an increased risk for acute coronary events and thromboembolism when older women received equine estrogens [27]. To our knowledge, data on the association of the M235T variant with CAD in women is currently not reported but angiotensinogen M235T variant has been associated with hypertension [9,41], preeclampsia in women [42], and myocardial infarction in men [43].…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

ACE-DD genotype is associated with the occurrence of acute coronary syndrome in postmenopausal women

Méthot

Hamelin

Bogaty³

et al. 2005

International Journal of Cardiology

View full text Add to dashboard Cite

Section: Introductioncontrasting

confidence: 92%

Section: Introductionmentioning

confidence: 82%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

ACE-DD genotype is associated with the occurrence of acute coronary syndrome in postmenopausal women

Méthot

Hamelin

Bogaty³

et al. 2005

International Journal of Cardiology

View full text Add to dashboard Cite

“…Moreover, the impact of diabetes mellitus and obesity on causing CVD is more severe in women (Reza, Reinhart, & Movahed, 2004). Another risk factor that is specific to women is attributed to ovarian disorders after menopause (Stone, 1996) (He, Sengupta, Velkoff, & DeBarros, 2005).…”

mentioning

confidence: 99%

A Study of the Knowledge, Attitudes, and Practices (KAP) of the Women Referred to Health Centers for Cardiovascular Disease (CVDs) and Their Risk Factors

Mazloomy

Baghianimoghadam

Ehrampoush

et al. 2013

Health Care for Women International

View full text Add to dashboard Cite

Hypertension, dyslipidemia, and diabetes are established risk factors for cardiovascular disease (CVD) morbidity and mortality. In the past decade a general increase in CVD risk factors in the population aged 65 and older, along with suboptimal control rates, have occurred. In this descriptive, cross-sectional study, the authors describe the knowledge, attitudes, and practices (KAP) of Iranian females regarding risk factors for CVD, in an attempt to help with the development of strategies to control risk factors and CVD. Participants were 200 women ages 15-49 referred to health centers in Yazd, selected from four different centers. Data were gathered through a questionnaire consisting of demographics and questions related to KAP. The validity of the questionnaire was determined by a health education specialist, with its reliability determined by piloting and measuring the related Cronbach's alpha (Alpha = 0.720). Measuring knowledge of CVD on a scale of 0-20, the mean knowledge score was 10.203.91. More than 76% of the participants knew that CVD is preventable. Ninety-one percent liked exercising and believed that exercising would make them feel better. The average mean scores for attitudes of participants toward CVD were 30.31 ± 3.21 out of 36. The authors conclude that there is a need for enhancing mothers' general knowledge about the disease, because of the increasing rates of CVD in females. This will lead to improvements in attitude and practice. Furthermore, learning in groups of 12 can be a beneficial educational method.

show abstract

“…Despite "optimal" medical therapy, a large fraction of patients continue to present with angina and myocardial ischemia [1]. It is recommended that treatment strategies should include modifying risk factors such as diet, weight loss, regular exercise, smoking cessation and adequate control of hypertension, diabetes, and hyperlipidemia [2]. Diltiazem (DTZ), losartan, amlodipine and dipyridamole are clinically proven effective cardiovascular agents for ischemic heart disease and have considerable potential for treatment and prevention of atherosclerosis and stroke [3][4][5].…”

Section: Introductionmentioning

confidence: 99%

Anti-Ischemia Drugs have no Effect on the In Vivo Metabolism of ATP by RBC in Normotensive Restrained Rats#

Yeung¹,

Dauphinee²,

Simonson³

et al. 2011

Open Drug Metab J

View full text Add to dashboard Cite

Abstract:The objective is to determine the effect of anti-ishemia agents on metabolism of adenosine-5'-triphosphate (ATP) in red blood cell (RBC) in a normotensive rat model. Male Sprague Dawley (SD) rats weighing between 300 -400 g were used. Each rat received either saline (control), or 5 mg/kg of diltiazem (DTZ), losartan, amlodipine or dipyridamole by subcutaneous injection (sc) twice daily for 5 doses. Blood samples were collected using a "Stopping Solution" from each rat at time 0 (before the last dose), and sequentially after over 6 hours following the last dose via an indwelling carotid artery catheter. In addition, hemodynamic recordings were collected throughout the experiment. Concentrations of ATP and other purine nucleotides in the RBC were determined by a validated HPLC. Data between groups were analyzed by ANOVA and paired t-test, and differences between groups considered significant when p < 0.05. The results showed that the concentrations of ATP and the other purine nucleotides in RBC of the rats treated with the anti-ischemia drugs were not different from the control rats ( Table 1). The concentrations of ATP and guanosine-5'-triphosphate (GTP) were higher towards the end of the experiment, but the increase was significant only after amlodipine and losartan (p < 0.05). The increase of ATP and AMP concentrations correlated with decrease of diastolic blood pressure (DBP) in the rats. The study concluded that the anti-ischemia drugs tested in the current study have no effect on RBC concentrations of ATP in the restraining rat model.

show abstract

Ischemic heart disease in women and the role of hormone therapy

Cited by 19 publications

References 191 publications

ACE-DD genotype is associated with the occurrence of acute coronary syndrome in postmenopausal women

ACE-DD genotype is associated with the occurrence of acute coronary syndrome in postmenopausal women

A Study of the Knowledge, Attitudes, and Practices (KAP) of the Women Referred to Health Centers for Cardiovascular Disease (CVDs) and Their Risk Factors

Anti-Ischemia Drugs have no Effect on the In Vivo Metabolism of ATP by RBC in Normotensive Restrained Rats#

Contact Info

Product

Resources

About