ACE-DD genotype is associated with the occurrence of acute coronary syndrome in postmenopausal women

Méthot, Julie; Hamelin, Bettina A.; Bogaty, Peter; Arsenault, Marie; Planté, Sylvain; Poirier, Paul

doi:10.1016/j.ijcard.2005.02.040

Cited by 12 publications

(9 citation statements)

References 46 publications

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“…CHD cases were defined in 16 studies as a >50% stenosis of at least one coronary vessel [7], [8], [10], [11], [34], [40], [41], [43], [46], [48], [50], [51], [54]–[57], while, in four studies, a >70% stenosis was considered [36], [42], [52], [58]. In 14 studies [13], [29]–[32], [35], [37]–[39], [44], [47], [49], [53], the WHO criteria were used, and, in four studies, CHD was diagnosed based on a clinical diagnosis [6], [33], [45]. Controls arose from the source population of the cases in 21 studies [6], [8], [13], [29], [31]–[33], [35]–[38], [45], [47], [49]–[53], [55], while hospital-based/not population-based controls were used in 17 studies [7], [10], [11], [30], [34], [39]–[44], [46], [48], [54], [56]–[58].…”

Section: Resultsmentioning

confidence: 99%

“…In 14 studies [13], [29]–[32], [35], [37]–[39], [44], [47], [49], [53], the WHO criteria were used, and, in four studies, CHD was diagnosed based on a clinical diagnosis [6], [33], [45]. Controls arose from the source population of the cases in 21 studies [6], [8], [13], [29], [31]–[33], [35]–[38], [45], [47], [49]–[53], [55], while hospital-based/not population-based controls were used in 17 studies [7], [10], [11], [30], [34], [39]–[44], [46], [48], [54], [56]–[58].…”

Section: Resultsmentioning

confidence: 99%

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The M235T Polymorphism in the AGT Gene and CHD Risk: Evidence of a Hardy-Weinberg Equilibrium Violation and Publication Bias in a Meta-Analysis

et al. 2008

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BackgroundThe M235T polymorphism in the AGT gene has been related to an increased risk of hypertension. This finding may also suggest an increased risk of coronary heart disease (CHD).Methodology/Principal FindingsA case-cohort study was conducted in 1,732 unrelated middle-age women (210 CHD cases and 1,522 controls) from a prospective cohort of 15,236 initially healthy Dutch women. We applied a Cox proportional hazards model to study the association of the polymorphism with acute myocardial infarction (AMI) (n = 71) and CHD. In the case-cohort study, no increased risk for CHD was found under the additive genetic model (hazard ratio [HR] = 1.20; 95% confidence interval [CI], 0.86 to 1.68; P = 0.28). This result was not changed by adjustment (HR = 1.17; 95% CI, 0.83 to 1.64; P = 0.38) nor by using dominant, recessive and pairwise genetic models. Analyses for AMI risk under the additive genetic model also did not show any statistically significant association (crude HR = 1.14; 95% CI, 0.93 to 1.39; P = 0.20). To evaluate the association, a comprehensive systematic review and meta-analysis were undertaken of all studies published up to February 2007 (searched through PubMed/MEDLINE, Web of Science and EMBASE). The meta-analysis (38 studies with 13284 cases and 18722 controls) showed a per-allele odds ratio (OR) of 1.08 (95% CI, 1.01 to 1.15; P = 0.02). Moderate to large levels of heterogeneity were identified between studies. Hardy-Weinberg equilibrium (HWE) violation and the mean age of cases were statistically significant sources of the observed variation. In a stratum of non-HWE violation studies, there was no effect. An asymmetric funnel plot, the Egger's test (P = 0.066), and the Begg-Mazumdar test (P = 0.074) were all suggestive of the presence of publication bias.Conclusions/SignificanceThe pooled OR of the present meta-analysis, including our own data, presented evidence that there is an increase in the risk of CHD conferred by the M235T variant of the AGT gene. However, the relevance of this weakly positive overall association remains uncertain because it may be due to various residual biases, including HWE-violation and publication biases.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

The M235T Polymorphism in the AGT Gene and CHD Risk: Evidence of a Hardy-Weinberg Equilibrium Violation and Publication Bias in a Meta-Analysis

et al. 2008

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“…Genetic markers offer the promise of identifying individual patients at increased risks of early disease-onset, or worse prognosis, and who may benefit from additional screening and early intervention. Genetic polymorphisms have been associated with increased risk for ACS [1], [2], [3], but the number of reports investigating genetic association with clinical outcome following specific ACS events is comparatively few [4], [5], [6].…”

Section: Introductionmentioning

confidence: 99%

Genetic Polymorphism rs6922269 in the MTHFD1L Gene Is Associated with Survival and Baseline Active Vitamin B12 Levels in Post-Acute Coronary Syndromes Patients

et al. 2014

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Background and AimsThe methylene-tetrahydrofolate dehydrogenase (NADP+ dependent) 1-like (MTHFD1L) gene is involved in mitochondrial tetrahydrofolate metabolism. Polymorphisms in MTHFD1L, including rs6922269, have been implicated in risk for coronary artery disease (CAD). We investigated the association between rs6922269 and known metabolic risk factors and survival in two independent cohorts of coronary heart disease patients.Methods and ResultsDNA and plasma from 1940 patients with acute coronary syndromes were collected a median of 32 days after index hospital admission (Coronary Disease Cohort Study, CDCS). Samples from a validation cohort of 842 patients post-myocardial infarction (PMI) were taken 24–96 hours after hospitalization. DNA samples were genotyped for rs6922269, using a TaqMan assay. Homocysteine and active vitamin B12 were measured by immunoassay in baseline CDCS plasma samples, but not PMI plasma. All cause mortality was documented over follow-up of 4.1 (CDCS) and 8.8 (PMI) years, respectively. rs6922269 genotype frequencies were AA n = 135, 7.0%; GA n = 785, 40.5% and GG n = 1020, 52.5% in the CDCS and similar in the PMI cohort. CDCS patients with AA genotype for rs6922269 had lower levels of co-variate adjusted baseline plasma active vitamin B12 (p = 0.017) and poorer survival than patients with GG or GA genotype (mortality: AA 19.6%, GA 12.0%, GG 11.6%; p = 0.007). In multivariate analysis, rs6922269 genotype predicted survival, independent of established covariate predictors (p = 0.03). However the association between genotype and survival was not validated in the PMI cohort.Conclusion MTHFD1L rs6922269 genotype is associated with active vitamin B12 levels at baseline and may be a marker of prognostic risk in patients with established coronary heart disease.

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“…23 In patients with type 1 diabetes and diabetic nephropathy, the II genotype acts as a protective factor for coronary heart disease. 7 Furthermore the D-allele confers an increased risk of MI [24][25][26] independently of other risk factors. RAS is implicated in prolonged QTc interval during hypoglycemia, 27 a condition that predisposes to ventricular arrhythmia.…”

Section: Discussionmentioning

confidence: 99%

ACE genotype, phenotype and all-cause mortality in different cohorts of patients with type 1 diabetes

Færch¹,

Sejling²,

Lajer

et al. 2013

J Renin Angiotensin Aldosterone Syst

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Aims: Carrying the D-allele of the angiotensin-converting enzyme (ACE) I/D polymorphism and high ACE activity are prognostic factors in diabetic nephropathy, which predicts mortality in type 1 diabetes. We studied the association between the ACE D-allele and ACE phenotype and long-term all-cause mortality in three single-institution outpatient cohorts. Methods: Genotype-based analyses were performed in 269 patients from Hillerød Hospital (HIH) (follow-up: 12 years) and in 439 patients with diabetic nephropathy and 437 patients with persistent normoalbuminuria from the Steno Diabetes Center (SDC) (follow-up: 9.5 years). Patients not on renin-angiotensin system (RAS)-blocking treatment were included in analyses of serum ACE activity (HIH: n = 208) and plasma ACE concentration (SDC: n=269). Results: In the HIH cohort, carrying a D-allele was associated with excess mortality (hazard ratio (HR) = 4.0 (95% confidence interval (CI) 1.0-16)), but not in the SDC cohorts. At HIH, serum ACE activity was associated with excess mortality (HR=1.04 (95% CI 1.0-1.1 per unit increase)), but in the SDC cohort plasma ACE concentration was not. Conclusion:In unselected patients with type 1 diabetes, carrying the ACE D-allele and high spontaneous serum ACE activity were associated with 12-year excess mortality. These findings could not be reproduced in two other cohorts with persistent normoalbuminuria or diabetic nephropathy.

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ACE-DD genotype is associated with the occurrence of acute coronary syndrome in postmenopausal women

Cited by 12 publications

References 46 publications

The M235T Polymorphism in the AGT Gene and CHD Risk: Evidence of a Hardy-Weinberg Equilibrium Violation and Publication Bias in a Meta-Analysis

The M235T Polymorphism in the AGT Gene and CHD Risk: Evidence of a Hardy-Weinberg Equilibrium Violation and Publication Bias in a Meta-Analysis

Genetic Polymorphism rs6922269 in the MTHFD1L Gene Is Associated with Survival and Baseline Active Vitamin B12 Levels in Post-Acute Coronary Syndromes Patients

ACE genotype, phenotype and all-cause mortality in different cohorts of patients with type 1 diabetes

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