Ischemic Preconditioning of Skeletal Muscle Mitigates Remote Injury and Mortality

Remote and local ischemic preconditioning equivalently protects rat skeletal muscle mitochondrial function during experimental aortic cross-clamping

“…9 Furthermore, many reports have demonstrated that IPC enhances protection not only of the limb but also of other organs. [14][15][16][17] Nevertheless, local IPC has potential disadvantages through direct stress to the target organ and mechanical trauma to major vascular structures that might limit its clinical application. 18 Remote IPC (rIPC), defined as an ischemic conditioning stimulus applied at a remote site, might overcome these limitations.…”

Remote Ischemic Preconditioning by Hindlimb Occlusion Prevents Liver Ischemic/Reperfusion Injury

“…6 For example, transient remote vascular occlusion has been shown to be protective of I/R injury in the heart, liver, lung, intestine, and kidney. [7][8][9][10] In man, RIPC has also been shown to be an effective strategy for preventing myocardial and renal I/R injury. Ali et al showed that brief occlusion of the common iliac artery prior to abdominal aortic aneurysm repair prevented postoperative heart and renal injuries.…”

Sequential Limb Ischemia Demonstrates Remote Postconditioning Protection of Murine Skeletal Muscle

“…8 This has been subsequently demonstrated in large-animal skeletal muscle and flap models, 9 -11 and more recently in murine skeletal muscle. 12 The first report of remote ischemic preconditioning in human subjects was recently published by Cheung et al In their study, 5-minute cycles of limb preconditioning using a blood pressure cuff had a remote myocardial protective effect in children undergoing repair of congenital heart defects. 13 However, the potential clinical applications of ischemic preconditioning have been limited by the need to initiate therapy before the onset of ischemia, which is not always plausible given the nature of many ischemic events.…”