Ischemic preconditioning of the muscle reduces the metaboreflex response of the knee extensors

Angius, Luca; Pageaux, Benjamin; Crisafulli, Antonio; Hopker, James G.; Marcora, Samuele Maria

doi:10.1007/s00421-021-04815-0

Cited by 9 publications

(10 citation statements)

References 82 publications

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“…One study found an attenuated hemodynamic response to metaboreflex activation during dynamic handgrip exercise preceded by IPC ( Mulliri et al, 2016 ), whereas another report did not show IPC to reduce hemodynamic responses or central muscle sympathetic nervous activity during activation of the metaboreflex ( Incognito et al, 2017 ). More recently, Angius et al (2022) corroborated the previously observed reduction in hemodynamic responses during metaboreflex activation using dynamic leg extension exercise. However, these authors also reported reduced end diastolic volumes following IPC which seems to indicate that altered hemodynamic responses during metaboreflex activation were due to blunted cardiac preload rather than discharge from group III/IV muscle afferents.…”

Section: Effect Of Ipc On Neurological and Perceptual Responses To Ex...supporting

confidence: 80%

“…Perhaps lending further support to the muscle afferent hypothesis is the evidence of IPC inducing hypoalgesic effects in humans. Indeed, previous investigations have demonstrated IPC techniques to reduce pressure pain ratings, pain under ischemia, perceived pain following eccentric exercise induced muscle damage, and time spent under pain during cold-water immersion tests ( Ferreira et al, 2016 ; Pereira et al, 2020 ; Slysz and Burr, 2021 ; Angius et al, 2022 ). IPC-induced hypoalgesia may be governed by endogenous substances that have antinociceptive effects on pain pathways.…”

Section: Effect Of Ipc On Neurological and Perceptual Responses To Ex...mentioning

confidence: 99%

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Potential physiological responses contributing to the ergogenic effects of acute ischemic preconditioning during exercise: A narrative review

O’Brien

Jacobs

2022

Front. Physiol.

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Ischemic preconditioning (IPC) has been reported to augment exercise performance, but there is considerable heterogeneity in the magnitude and frequency of performance improvements. Despite a burgeoning interest in IPC as an ergogenic aid, much is still unknown about the physiological mechanisms that mediate the observed performance enhancing effects. This narrative review collates those physiological responses to IPC reported in the IPC literature and discusses how these responses may contribute to the ergogenic effects of IPC. Specifically, this review discusses documented central and peripheral cardiovascular responses, as well as selected metabolic, neurological, and perceptual effects of IPC that have been reported in the literature.

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Section: Effect Of Ipc On Neurological and Perceptual Responses To Ex...supporting

confidence: 80%

Section: Effect Of Ipc On Neurological and Perceptual Responses To Ex...mentioning

confidence: 99%

Potential physiological responses contributing to the ergogenic effects of acute ischemic preconditioning during exercise: A narrative review

O’Brien

Jacobs

2022

Front. Physiol.

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“…Finally, we acknowledge that BP responses to PECO may have been lower because of mechanisms unrelated to the change in MVC. Ischemic preconditioning (brief cyclic bouts of limb ischemia and reperfusion) has been shown to reduce BP responses to PECO but not static exercise (58). Because exercise can elicit similar cardioprotective effects to ischemic preconditioning (59), the eccentric exercise bout may have induced a preconditioning effect and blunted the BP response to PECO.…”

Section: Discussionmentioning

confidence: 99%

Blood Pressure Responses to Postexercise Circulatory Occlusion Are Attenuated After Exercise-Induced Muscle Weakness

Lee

Katerberg

Bommarito

et al. 2023

Medicine &Amp; Science in Sports &Amp; Exercise

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Purpose Exercise blood pressure (BP) responses are thought to be determined by relative exercise intensity (percent maximal voluntary contraction (MVC) strength). However, cross-sectional studies report that during a static contraction, higher absolute force is associated with greater BP responses to relative intensity exercise and subsequent muscle metaboreflex activation with postexercise circulatory occlusion (PECO). We hypothesized that a bout of unaccustomed eccentric exercise would reduce knee extensor MVC and subsequently attenuate BP responses to PECO. Methods Continuous BP, heart rate, muscle oxygenation, and knee extensor electromyography were recorded in 21 young healthy individuals (female, n = 10) during 2 min of 20% MVC static knee extension exercise and 2 min of PECO, performed before and 24 h after 300 maximal knee extensor eccentric contractions to cause exercise-induced muscle weakness. As a control, 14 participants repeated the eccentric exercise 4 wks later to test whether BP responses were altered when exercise-induced muscle weakness was attenuated via the protective effects of the repeated bout effect. Results Eccentric exercise reduced MVC in all participants (144 ± 43 vs 110 ± 34 N·m, P < 0.0001). BP responses to matched relative intensity static exercise (lower absolute force) were unchanged after eccentric exercise (P > 0.99) but were attenuated during PECO (systolic BP: 18 ± 10 vs 12 ± 9 mm Hg, P = 0.02). Exercise-induced muscle weakness modulated the deoxygenated hemoglobin response to static exercise (64% ± 22% vs 46% ± 22%, P = 0.04). When repeated after 4 wks, exercise-induced weakness after eccentric exercise was attenuated (−21.6% ± 14.3% vs −9.3 ± 9.7, P = 0.0002) and BP responses to PECO were not different from control values (all, P > 0.96). Conclusions BP responses to muscle metaboreflex activation, but not exercise, are attenuated by exercise-induced muscle weakness, indicating a contribution of absolute exercise intensity on muscle metaboreflex activation.

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“…We therefore recommend, similarly to others [14, 29, 133], that researchers and clinicians instruct and familiarize their participants to rate their perception of effort specifically by excluding other exercise-related perception(s) from their sense of effort. This is also crucial for researchers investigating the perception of effort as a psychophysiological marker of the magnitude of the motor command [e.g., 88, 90] and using muscle pain as a psychophysiological marker of feedback from group III-IV muscle afferents [e.g., 136, 137].…”

Section: Discussionmentioning

confidence: 99%

Pharmacological blockade of muscle afferents and perception of effort: a systematic review with meta-analysis

Bergevin

Steele

Garanderie

et al. 2021

Preprint

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The perception of effort (PE) provides information on task difficulty and influences physical exercise regulation and human behavior. This perception differs from other-exercise related perceptions such as pain. There is no consensus on the role of group III-IV muscle afferents as a signal processed by the brain to generate PE. The aim of this meta-analysis was to investigate the effect of pharmacologically blocking muscle afferents on the PE. Six databases were searched to identify studies measuring the ratings of perceived effort (RPE) during physical exercise, with and without pharmacological blockade of muscle afferents. Articles were coded based on the operational measurement used to distinguish studies in which PE was assessed specifically (effort dissociated) or as a composite experience including other exercise-related perceptions (effort not dissociated). Articles that did not provide enough information for coding were assigned to the unclear group. The effort dissociated group (n=6) demonstrated a slight RPE increase with reduced muscle afferents feedback (standard mean change raw (SMCR), 0.39; 95%CI, 0.13 to 0.64). The group effort not dissociated (n=2) did not reveal conclusive results (SMCR, -0.29; 95%CI, -2.39 to 1.8). The group unclear (n=8) revealed a slight RPE decrease with reduced muscle afferents feedback (SMCR, -0.27; 95%CI, -0.50 to -0.04). The heterogeneity in results between groups reveals that the inclusion of other perceptions than effort in its rating influences the RPE scores reported by the participants. The absence of decreased RPE in the effort dissociated group suggests that muscle afferents feedback is not a sensory signal generating PE.

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Ischemic preconditioning of the muscle reduces the metaboreflex response of the knee extensors

Cited by 9 publications

References 82 publications

Potential physiological responses contributing to the ergogenic effects of acute ischemic preconditioning during exercise: A narrative review

Potential physiological responses contributing to the ergogenic effects of acute ischemic preconditioning during exercise: A narrative review

Blood Pressure Responses to Postexercise Circulatory Occlusion Are Attenuated After Exercise-Induced Muscle Weakness

Pharmacological blockade of muscle afferents and perception of effort: a systematic review with meta-analysis

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