Islet autoantibody development during follow-up of high-risk children from the general Norwegian population from three months of age: Design and early results from the MIDIA study

Stene, Lars C.; Witsø, Elisabet; Torjesen, Peter A.; Rasmussen, Trond; Magnus, Per; Cinek, Ondřej; Wetlesen, Turid; Rønningen, Kjersti S.

doi:10.1016/j.jaut.2007.04.003

Cited by 51 publications

(55 citation statements)

References 68 publications

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“…In birth cohort studies, seroconversion for diseasepredictive islet autoantibodies has occasionally been shown to occur before 6 months of age [35]. Long-term follow-up has shown a peak incidence of seroconversion for islet autoantibodies at around 9-18 months of age, and most of those who progress to type 1 diabetes during childhood express islet autoantibodies before 2-4 years of age [24,25].…”

Section: Natural History Of Type 1 Diabetesmentioning

confidence: 99%

The prenatal environment and type 1 diabetes

Stene

Gale

2013

Diabetologia

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Section: Natural History Of Type 1 Diabetesmentioning

confidence: 99%

The prenatal environment and type 1 diabetes

Stene

Gale

2013

Diabetologia

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“…Islet autoantibodies may appear before 6 months, often in the first 1-4 years of life (12,13), and tissue transglutaminase autoantibodies somewhat later (11,25). Perinatal factors such as birth weight and caesarean section have been associated with both type 1 diabetes and celiac disease (26)(27)(28).…”

Section: Early Environmental Factors In Celiac Disease and Type 1 Diamentioning

confidence: 99%

“…Circulating autoantibodies may be predictive of clinical disease months and years before onset of both diseases (1,4,11). The fact that these may appear before six months of age and frequently appear before two to three years of age (12,13) suggest that factors influencing the seroconversion operate early in life.…”

Section: Introductionmentioning

confidence: 99%

Prediction of autoimmune diabetes and celiac disease in childhood by genes and perinatal environment: Design and initial aims of the PAGE study

Stene¹,

Joner²,

Størdal³

2014

Nor J Epidemiol

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Type 1 diabetes and celiac disease result from misdirected immune mediated destruction of host cells, and are among the most common chronic diseases in children. Despite changes in incidence over the past 3 decades, little is known about non-genetic risk factors (except for dietary gluten for celiac disease). Norway is among the countries in the world with the highest incidence of these two diseases. We describe here plans and study design for the PAGE study (Prediction of Autoimmune diabetes and celiac disease in childhood by Genes and perinatal Environment). PAGE is a sub-study within the Norwegian Mother and Child Cohort study, including follow-up of more than 100,000 pregnancies. Children who develop type 1 diabetes or celiac disease are identified via linkage to the Norwegian Patient Register and the Norwegian Childhood Diabetes Registry, with complementing information from questionnaires. The overall aim is to test hypotheses about potential non-genetic risk factors for type 1 diabetes and for celiac disease, with focus on factors operating early in life. In addition to a full cohort analysis of factors registered in questionnaires, we will analyse biomarkers in maternal blood plasma and cord blood plasma. Mothers and children will be genotyped for well-established susceptibility polymorphisms. Biomarkers will be analysed in cases and controls within the cohort. Factors to be tested in the full cohort include infant feeding, diet and dietary supplements in the mother during pregnancy and in the child, and use of antibiotics and non-prescription drugs. Biomarkers to be tested include 25-hydroxyvitamin D, markers of immune activation, and small metabolites (metabolomics). We will also explore the potential role of maternal cells in the fetal circulation (maternal microchimerism) in later risk of celiac disease and type 1 diabetes.This is an open access article distributed under the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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“…Information from questionnaires, public records as well as blood samples from mothers (twice during pregnancy) and children (cord blood) have been collected from 107,000 pregnancies Rønningen et al, 2006). 50% of the children participating in MIDIA have a mother who also participates in MoBa, and consent has been given for linking information from the two studies and using biological specimens (Stene et al, 2007).…”

Section: Nutritional Related Factors and Type 1 Diabetes Riskmentioning

confidence: 99%

“…Blood samples were taken at the same intervals. After this period, a questionnaire and a blood sample are asked for annually (Stene et al, 2007). For more information on MIDIA, see www.fhi.no/midia.…”

Section: Research Design and Subjectsmentioning

confidence: 99%

Genetic Testing of Newborns for Type 1 Diabetes Susceptibility – The MIDIA Study

Rønningen¹

2011

Type 1 Diabetes - Complications, Pathogenesis, and Alternative Treatments

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Islet autoantibody development during follow-up of high-risk children from the general Norwegian population from three months of age: Design and early results from the MIDIA study

Cited by 51 publications

References 68 publications

The prenatal environment and type 1 diabetes

The prenatal environment and type 1 diabetes

Prediction of autoimmune diabetes and celiac disease in childhood by genes and perinatal environment: Design and initial aims of the PAGE study

Genetic Testing of Newborns for Type 1 Diabetes Susceptibility – The MIDIA Study

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