Islington study of dementia subtypes in the community

Stevens, Tim; Livingston, Gill; Kitchen, Ginnette; Manela, Mônica; Walker, Zuzana; Katona, Cornelius

doi:10.1192/bjp.180.3.270

Cited by 181 publications

(145 citation statements)

References 29 publications

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“…Three of six United Kingdom population-based studies of late-onset dementia included information on subtype diagnoses (Alzheimer's disease, VaD or mixed dementia and "other") (48-50). A more recent communitybased study (51) provided information on the relative frequency of a wider range of subtypes; Alzheimer's disease (41%), VaD (32%), dementia in Parkinson's Disease (3%), FTD (3%) and DLB (8%); Only the EURODEM meta-analysis of studies in the 1990s provided gender-as well as age-specific proportions with Alzheimer's disease and VaD (37). In that study, while the proportion with Alzheimer's disease among females remained constant at around 70%, among men the proportion increased progressively from 38% among those aged 65-69 years to 80% in those over 90 years of age.…”

Section: Reviewmentioning

confidence: 99%

Nursing Students' Intentions to Work in Dementia Care: Influence of Age, Ageism, and Perceived Barriers

McKenzie

Brown

2014

Educational Gerontology

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Section: Reviewmentioning

confidence: 99%

Nursing Students' Intentions to Work in Dementia Care: Influence of Age, Ageism, and Perceived Barriers

McKenzie

Brown

2014

Educational Gerontology

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“…Alzheimer disease accounts for 31% of those with dementia, presenting with short-term memory decline, language dysfunction, neuropsychiatric features, and, in 5% of cases, parkinsonism. [47][48][49] Dementia with Lewy bodies accounts for approximately 11% of patients with dementia and can present with falls or depression, which are also seen in Alzheimer disease; fluctuating dementia; and the more discriminatory presentations of visual hallucinations, multiple features, and, in 41% of cases, parkinsonism. Of note, the clinical features of parkinsonism in both forms of dementia are less severe than those seen in idiopathic Parkinson disease, presenting commonly with rigidity and bradykinesia and infrequently with resting tremor.…”

Section: Dementia With Lewy Bodiesmentioning

confidence: 99%

The Role of Functional Dopamine-Transporter SPECT Imaging in Parkinsonian Syndromes, Part 2

Booth

Nathan

Waldman

et al. 2014

AJNR Am J Neuroradiol

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SUMMARY:The functional imaging technique most widely used in European clinics to differentiate a true parkinsonian syndrome from vascular parkinsonism, drug-induced changes, or essential tremor is dopamine-transporter SPECT. This technique commonly reports dopamine-transporter function, with decreasing striatal uptake demonstrating increasingly severe disease. The strength of dopaminetransporter SPECT is that nigrostriatal degeneration is observed in both clinically inconclusive parkinsonism and early, even premotor, disease. In this clinical review (Part 2), we present the dopamine-transporter SPECT findings in a variety of neurodegenerative diseases, including multiple system atrophy, progressive supranuclear palsy, corticobasal degeneration, and dementia with Lewy bodies. The findings in vascular parkinsonism, drug-induced parkinsonism, and essential tremor are also described. It is hoped that this technique will be the forerunner of a range of routinely used, process-specific ligands that can identify early degenerative disease and subsequently guide disease-modifying interventions.

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“…The proportion of FTD in relation to organic dementia in the present study was compared with the results from other studies [7,9,13,15,36,[43][44][45][46][47] (table 3). There were three population studies, of which two were based on patients admitted to clinics [7,9].…”

Section: Proportion Of Ftd In Relation To Organic Dementiamentioning

confidence: 89%

“…There were three population studies, of which two were based on patients admitted to clinics [7,9]. The remaining study identified subtypes of dementia in a representative community by screening persons directly in their homes [47]. The diagnostic criteria of FTD were commonly the Lund-Manchester criteria [1] except for two studies [46,47] that used the revised clinical version of Neary et al [3].…”

Section: Proportion Of Ftd In Relation To Organic Dementiamentioning

confidence: 99%

Dementia in First-Degree Relatives of Patients with Frontotemporal Dementia

Gräsbeck¹,

Horstmann²,

Nilsson³

et al. 2005

Dement Geriatr Cogn Disord

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Several studies have found a clustering of dementia in relatives of patients with frontotemporal dementia (FTD). This study analysed the familial aggregation of FTD specifically as well as the occurrence of dementia in general in first-degree relatives of patients with FTD. A family history study was carried out on 478 first-degree relatives of 74 index patients suffering from FTD. Cases of organic dementia and of FTD were diagnosed according to internationally accepted diagnostic criteria. Age- and sex-specific incidences of organic dementia and of FTD were calculated as was the proportion of FTD in relation to organic dementia in general; comparisons with clinical and population studies were made. There was a tenfold increase in the incidence of FTD in the first-degree relatives of FTD patients compared with the incidence of FTD in a population study. The proportion of FTD in relation to all types of organic dementia was much higher in relatives of FTD patients compared to the corresponding proportions in clinical and population-based studies. There was a small, non-significant difference between the present family history study and the population studies as regards the incidence of organic dementia. The findings suggest that hereditary and/or shared environmental factors are strongly involved in the aetiology of FTD. There were no indications of familial clustering of organic dementia in general in relatives of FTD patients.

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Islington study of dementia subtypes in the community

Abstract: Alzheimer's disease is confirmed as the most common cause of dementia in older people, followed by vascular dementia. However, DLB and FLD occur sufficiently often to be seen frequently in clinical practice and should be incorporated into future editions of standard diagnostic criteria.

Cited by 181 publications

References 29 publications

Nursing Students' Intentions to Work in Dementia Care: Influence of Age, Ageism, and Perceived Barriers

Nursing Students' Intentions to Work in Dementia Care: Influence of Age, Ageism, and Perceived Barriers

The Role of Functional Dopamine-Transporter SPECT Imaging in Parkinsonian Syndromes, Part 2

Dementia in First-Degree Relatives of Patients with Frontotemporal Dementia

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