Isobavachalcone from Angelica keiskei Inhibits Adipogenesis and Prevents Lipid Accumulation

Lee, Hyejin; Li, Hua; Kweon, Minson; Choi, Yeo Jin; Kim, Min Jung; Ryu, Jae‐Ha

doi:10.3390/ijms19061693

Cited by 35 publications

(24 citation statements)

References 51 publications

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“…DFS (10 µM) also suppressed adipocyte growth without cytotoxicity during differentiation, as assessed by MTT assay ( Figure 1 C). As previously reported, MDI treatment increased cell growth compared to the respective ND group on differentiation days 2, 4, and 8 (D2, D4, and D8) [ 17 ]. DFS significantly inhibited cell growth by 54.1% (D2), 54.5% (D4), and 81.2% (D8), respectively, when compared to comparable MDI treatment cells.…”

Section: Resultssupporting

confidence: 67%

“…Recently, several small molecules were reported to inhibit adipocyte differentiation by preventing further cell cycle progression at the MCE stage [ 25 , 26 ]. For example, isobavachalcone, curcumin, and resveratrol were reported to inhibit cell cycle progression via G0/G1 arrest [ 4 , 6 , 17 ]. They reduce the expression of cyclin D1, cyclin B1, cdk-4, and cdk-6 in adipocytes, resulting in cell cycle arrest and the suppression of MCE.…”

Section: Discussionmentioning

confidence: 99%

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Lignan from Alnus japonica Inhibits Adipocyte Differentiation via Cell Cycle and FOXO1 Regulation

2020

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In the present study, we isolated a lignan ((−)-(2R,3R)-1,4-O-diferuloylsecoisolariciresinol, DFS) from Alnus japonica and evaluated its antiobesity potential in vitro. We also determined its mechanism of action in a mouse pre-adipocyte 3T3-L1 cell line. DFS dose- and day-dependently inhibited adipogenesis by downregulation of adipogenic factors and lipid metabolism-regulating factors during adipocyte differentiation. In particular, DFS suppressed cell cycle-regulating factors and induced G0/G1 cell cycle arrest, implying that it had an inhibitory effect on mitotic clonal expansion which occurred at an early stage of adipogenesis. DFS also suppressed adipogenesis through decreasing Akt phosphorylation and increasing the level of Forkhead box protein-O1 (FOXO1). These results suggest that DFS may be a pharmacological candidate for the development of antiobesity, therapeutic, and nutraceutical products.

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Section: Resultssupporting

confidence: 67%

Section: Discussionmentioning

confidence: 99%

Lignan from Alnus japonica Inhibits Adipocyte Differentiation via Cell Cycle and FOXO1 Regulation

2020

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“…PPARgamma (PPARγ), a major regulator of adipogenesis, is a nuclear receptor and is a part of the PPARs family. It accumulates particularly in adipose tissues to regulate the expression of genes with their essential role to differentiate [24]. Growth of triglycerides (TG) in mature adipocyte is triggered when adipogenic transcriptional factors such as PPARγ/CCAT/enhancer-binding protein (C/EBP) are expressed [24].…”

Section: Introductionmentioning

confidence: 99%

“…It accumulates particularly in adipose tissues to regulate the expression of genes with their essential role to differentiate [24]. Growth of triglycerides (TG) in mature adipocyte is triggered when adipogenic transcriptional factors such as PPARγ/CCAT/enhancer-binding protein (C/EBP) are expressed [24]. It leads to a pathway to regulate fatty acid synthase (FAS) and acetyl-CoA carboxylase (ACC) [25].…”

Section: Introductionmentioning

confidence: 99%

Phenolic Compounds with Antioxidant Properties from Canola Meal Extracts Inhibit Adipogenesis

Hussain

Rehman

Luckett

et al. 2019

IJMS

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The extraction of phenolic compounds from canola meal produces functional health products and renders the canola meal a more digestible animal feed. The extracted phenolics may have novel bioactivity worth investigation. In this study, several solvents were evaluated for their ability to extract phenolic compounds from canola meal: water (WE) and various 80% organic solvent/water mixtures of methanol (ME), acetone (AE), ethanol (EE), butanol (BE), chloroform (CE) and hexane (HE). The in vitro antioxidant and anti-obesity properties of various extracts were investigated. Anti-obesity properties were studied using adipogenic differentiation inhibition of a murine mesenchymal stem cell line (C3H10T1/2) and a pancreatic lipase inhibition assay. AE, ME, and BE showed significant (p < 0.05) adipogenesis and pancreatic lipase inhibitory activities and may have more pharmacological properties. AE down-regulated the gene expression of the major adipogenic transcription factor, peroxisome proliferator-activated receptor gamma (PPARγ), correlating to phenolic content in a dose-dependent manner. The chemical characterization of AE revealed the presence of sinapic acid, ferulic acid, and kaempferol derivatives as main bioactive phenols.

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“…There is a recognized efficacy of the natural compounds combined with pharmacological treatment for the treatment of obesity, and thus there is a need to continually explore new anti-obesity compounds [43].…”

Section: Drug Screening and Treatmentmentioning

confidence: 99%

Zebrafish as an Experimental Model for the Study of Obesity

Virote¹,

Vianna²,

Murgas³

2020

Zebrafish in Biomedical Research

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Obesity is considered a silent global pandemic, with a steady increase in adults and children. It is a complex disease that involves the interaction of genetic and environmental factors and predisposes individuals to severe chronic complications such as various types of cancer, dyslipidemia, hyperglycemia, hypercholesterolemia, nonalcoholic fatty liver disease (NAFLD), and nonalcoholic steatohepatitis. To help elucidate the physiological mechanisms of this comorbidity in order to identify and develop effective treatments, the use of animal models is indispensable. Zebrafish is emerging as an important model for studying obesity and related metabolic diseases. In addition to being a small animal, with high genetic similarity when compared to humans and easy to handle, zebrafish also has the main well-conserved metabolism-related functions such as appetite regulation, insulin regulation, and lipid storage. Zebrafish is also suitable for the identification of new targets associated with the risk and treatment of obesity in humans. In this review, we highlight the studies that use zebrafish to study metabolic diseases demonstrating their important contribution in this area of research.

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Isobavachalcone from Angelica keiskei Inhibits Adipogenesis and Prevents Lipid Accumulation

Cited by 35 publications

References 51 publications

Lignan from Alnus japonica Inhibits Adipocyte Differentiation via Cell Cycle and FOXO1 Regulation

Lignan from Alnus japonica Inhibits Adipocyte Differentiation via Cell Cycle and FOXO1 Regulation

Phenolic Compounds with Antioxidant Properties from Canola Meal Extracts Inhibit Adipogenesis

Zebrafish as an Experimental Model for the Study of Obesity

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