Isocyanate-induced pulmonary diseases: a current perspective

Il, Bernstein

doi:10.1016/0091-6749(82)90197-x

Cited by 147 publications

(55 citation statements)

References 38 publications

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“…Specific IgE antibodies to a protein conjugate of monoisocyanate have been found in 10-20% of symptomatic workers (83). There is some evidence that IgE antibodies and lymphocytes may react to a neoantigen formed by a reaction of these compounds with self-proteins (87). The pathologic condition of lungs in patients with diisocyanateinduced asthma was no different from that in allergic asthma (88).…”

Section: Isocyanatesmentioning

confidence: 95%

Occupational asthma

Quirce¹,

Sastre²

1998

Allergy

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Section: Isocyanatesmentioning

confidence: 95%

Occupational asthma

Quirce¹,

Sastre²

1998

Allergy

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“…Dies mag mit der Verschiedenheit -aber auch mit unzureichender Spezifität -der verwendeten Antigene zusammenhän-gen. Isocyanat-Intrakutan-Tests korrelieren befriedigend mit dem RAST [51]. Neuerdings werden auch immunzelluläre Mechanismen diskutiert [56][57][58][59][60]. Für pharmakologische Pathomechanismen sprechen Hemmeffekte der Isocyanate auf Cholinesterase [61,62] und auf das Adenyl-Cyclase-System [63][64][65][66].…”

Section: Sensibilisierung Allgemeinesunclassified

Diisocyanate [MAK Value Documentation in German language, 1984]

2012

The MAK‐Collection for Occupational Health and Safety

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Veröffentlicht in der Reihe Gesundheitsschädliche Arbeitsstoffe , 10. Lieferung, Ausgabe 1984 Der Artikel enthält folgende Kapitel: Allgemeiner Wirkungscharakter Schleichende Verschlechterung der Atemfunktion durch Isocyanate Sensibilisierung Allgemeines Tierexperimentelle Beobachtungen Beobachtungen beim Menschen Mutagenität, Kanzerogenität und Fetotoxizität Begründung des MAK‐Wertes

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“…In many industrialized countries, isocyanates such as toluene diisocyanate (TDI), 4,4'-methylenediphenyl diisocyanate (MDI) and 1,6'-hexamethylene diisocyanate (HDI) are commonly utilized in industry as cross-linking and polymerizing agents in the manufacture of urethane foams, elastmers, polyurethane coating, adhesives and paints (1). TDI, MDI and HDI are the best examples of the diisocyanate group of chemicals, used for urethane products.…”

Section: Introductionmentioning

confidence: 99%

Diagnosis and prevention of diseases induced by isocyanate

Nakashima

Takeshita

Morimoto

2002

Environ Health Prev Med

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Isocyanates are among the most frequent causes of occupational asthma in industrialized countries. Early diagnosis of diisocyanate asthma followed by prompt termination of chemical exposure can prevent chronic morbidity due to persistent asthma. Chronic exposure to isocyanates also induces hypersensitivity pneumonitis (HP). The accurate diagnosis of diisocynate asthma requires a systematic approach that combines information obtained from the occupational history, immunologic tests and physiologic studies. The prevention of health problems from toluene diisocyanate (TDI), 4,4'-methylenediphenyl diisocyanate (MDI) and 1,6'-hexamethylene diisocyanate (HDI) is essential for all those handling the chemicals. Regulatory exposure limits should be observed. However, wheezing, coughing or even asthmatic attacks may occur after exposure much below the regulatory exposure limits especially in sensitive individuals. Preventing or minimizing exposure is of prime importance and should be supported by the installation of engineering controls, by education of the workforce, by regular monitoring of the workplace exposure and by medical surveillance. To prevent such asthma it is suggested that workers should be tested airway sensitivity and should avoid working in areas that have dust containing specific-IgE. Such tests must be periodically performed after working. Symptoms induced by isocyanate need earlier discover and early isolation of the associated individuals.

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Isocyanate-induced pulmonary diseases: a current perspective

Cited by 147 publications

References 38 publications

Occupational asthma

Occupational asthma

Diisocyanate [MAK Value Documentation in German language, 1984]

Diagnosis and prevention of diseases induced by isocyanate

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