Isoeugenol: A survey of consumer patch-test sensitization

Thompson, G.R.; Booman, K.A.; Dorsky, J.; Kohrman, K.A.; Rothenstein, A.S.; Schwoeppe, E.A.; Sedlak, Richard; Steltenkamp, R.J.

doi:10.1016/0278-6915(83)90205-3

Cited by 17 publications

(4 citation statements)

References 10 publications

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“…Basketter (2003); Gerberick et al (1992); Hilton et al (1998); Sailstad et al (1995) 1073 Marzulli and Maibach (1974) Glyoxal (107- (2003); Basketter et al (1994Basketter et al ( , 2001b; Basketter and Kimber (2001); Basketter and Scholes (1992); Montelius et al (1994) 3937 4311 Jordan and King (1977); Ford et al (1988); Marzulli and Maibach (1980); Steltenkamp et al (1980b) Imidazolidinyl urea (39236-46-9) 6952 Basketter (2003); Basketter and Scholes (1992) 3846 Jordan and King (1977) Isoeugenol (97-54-1) 524 Basketter (2003); Basketter and Kimber (2001); Basketter and Scholes (1992); Kimber and Weisenberger (1991); Loveless et al (1996); Wright et al (2001) 657 Marzulli and Maibach (1980); Thompson et al (1983) Kanamycin (59-01-8) 2075…”

Section: Discussionmentioning

confidence: 97%

Quantitative relationship between the local lymph node assay and human skin sensitization assays

Schneider

Akkan

2004

Regulatory Toxicology and Pharmacology

105

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Section: Discussionmentioning

confidence: 97%

Quantitative relationship between the local lymph node assay and human skin sensitization assays

Schneider

Akkan

2004

Regulatory Toxicology and Pharmacology

105

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“…Isoeugenol is one of the most important sensitizing fragrance substances still in use. It is a strong sensitizer in animal (1) and human experiments (2), and it is frequently reported as the cause of allergic patch test reactions in dermatitis patients (3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13). Isoeugenol is one of the constituents of the fragrance mix (FM) present in the European and many other standard series for patch testing (7,8).…”

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confidence: 99%

Deodorants: an experimental provocation study with isoeugenol

et al. 2005

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Axillary dermatitis is common and overrepresented in people with contact allergy to fragrances. Many people suspect their deodorants to be the incriminating products. In order to investigate the significance of isoeugenol in deodorants for the development of axillary dermatitis when used by people with and without contact allergy to isoeugenol, patch tests with deodorants and ethanol solutions with isoeugenol, as well as repeated open application tests (ROAT) with roll-on deodorants with and without isoeugenol at various concentrations, were performed in 35 dermatitis patients, 10 without and 25 with contact allergy to isoeugenol. A positive ROAT was observed only in patients hypersensitive to isoeugenol (P<0.001) and only in the axilla to which the deodorants containing isoeugenol had been applied (P<0.001). Deodorants containing isoeugenol in the concentration range of 0.0063-0.2% used 2 times daily on healthy skin can thus elicit axillary dermatitis within a few weeks in people with contact allergy to isoeugenol.

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“…Furthermore, Andersen et al [17] used the timeedoseeresponse relationship to confirm that isoeugenol elicited contact dermatitis. Perfumes based on natural ingredients contain fragrant allergenic species such as eugenol and isoeugenol, which have been confirmed to induce allergies when the content is excessively high [18,19]. The characteristics of these allergenic species have not been completely specified because the cellular and molecular mechanisms of respiratory allergic reaction remain unclear.…”

Section: Introductionmentioning

confidence: 99%