Isoflavones from green vegetable soya beans and their antimicrobial and antioxidant activities

Wang, Taoyun; Li, Yanli; Li, Xiaoran; Xu, Qiong; Feng, Yulin; Yang, Shilin

doi:10.1002/jsfa.8663

Cited by 32 publications

(21 citation statements)

References 15 publications

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“…Genus Trifolium (Fabaceae) contains 250 species, most of which have been documented as rich source of formononetin [13]. In addition to this family, formononetin is also present in different plants including Trifolium pratense [14] , Glycine max [15, 16], Sophora flavescens [17], Pycnanthus angolensis [18], Spatholobus suberectus [19], Cicer arietinum [20], Dalbergia odorifera, Pueraria thunbergiana [21], Actaea racemosa [22], Ononis spinosa L. [9], Dalbergia ecastaphyllum [23], Callerya speciosa [24], Astragalus membranaceus [25], and Astragalus mongholicus as shown in Figure 1. The list of plants having Formononetin, their parts, and pharmacological properties are elaborated in Table 1.…”

Section: Natural Sources Of Formononetinmentioning

confidence: 99%

“…The biological and pharmacological activities of bioactive compound “Formononetin” are well-documented as antitumor activity, [23] antiproliferative activity [14], growth inhibitory activity [55], vasorelaxant action [56], neuroprotective effect [57], antiapoptotic activity [48], cardioprotective activity [58], mammary gland proliferative activity [59], antioxidant activity [60], antimicrobial activity, and anti-inflammatory activity [15] as provided in Figure 2. Numerous in vivo/in vitro investigations have been done on Formononetin to uncover its biological attributes and mechanisms of actions.…”

Section: Biological Activities Of Formononetin and Mechanisms Of Imentioning

confidence: 99%

“…Brazilian Red propolis extract containing isoflavonoids such as Formononetin exhibits anti-inflammatory potential in a rat model of inflammation [89]. Isoflavones such as Formononetin isolated from soy bean possess antimicrobial and antioxidant activities with IC 50 values from 10.6 to 22.6 μ g/mL [15]. A study indicates that a methoxy Isoflavone, Formononetin, has potential for bone healing process in mouse model and has promising role in fracture-repair process [90].…”

Section: Other Biological Functionsmentioning

confidence: 99%

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Potential Anticancer Properties and Mechanisms of Action of Formononetin

Jiang

Rasul

Batool

et al. 2019

BioMed Research International

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Nature, a vast reservoir of pharmacologically active molecules, has been most promising source of drug leads for the cure of various pathological conditions. Formononetin is one of the bioactive isoflavones isolated from different plants mainly from Trifolium pratense, Glycine max, Sophora flavescens, Pycnanthus angolensis, and Astragalus membranaceus. Formononetin has been well-documented for its anti-inflammatory, anticancer, and antioxidant properties. Recently anticancer activity of formononetin is widely studied. This review aims to highlight the pharmacological potential of formononetin, thus providing an insight of its status in cancer therapeutics. Formononetin fights progression of cancer via inducing apoptosis, arresting cell cycle, and halting metastasis via targeting various pathways which are generally modulated in several cancers. Although reported data acclaims various biological properties of formononetin, further experimentation on mechanism of its action, medicinal chemistry studies, and preclinical investigations are surely needed to figure out full array of its pharmacological and biological potential.

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Section: Natural Sources Of Formononetinmentioning

confidence: 99%

Section: Biological Activities Of Formononetin and Mechanisms Of Imentioning

confidence: 99%

Section: Other Biological Functionsmentioning

confidence: 99%

See 1 more Smart Citation

Potential Anticancer Properties and Mechanisms of Action of Formononetin

Jiang

Rasul

Batool

et al. 2019

BioMed Research International

View full text Add to dashboard Cite

show abstract

“…2′-Hydroxyerythrin A with the OH group from C-5 shifted to C-2′ showed good activity against several Gram-positive and Gram-negative bacteria (Wang et al, 2018). The magnitude of the DPPH radical scavenging effect was in the same range (Wang et al, 2018) as in some studies with AIF (Rahman et al, 2010; Bórquez et al, 2013; Fu et al, 2018).…”

Section: Structure-activity Relationshipmentioning

confidence: 99%

A Pharmacological Overview of Alpinumisoflavone, a Natural Prenylated Isoflavonoid

et al. 2019

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Over the last decade, several studies demonstrated that prenylation of flavonoids enhances various biological activities as compared to the respective nonprenylated compounds. In line with this, the natural prenylated isoflavonoid alpinumisoflavone (AIF) has been explored for a number of biological and pharmacological effects (therapeutic potential). In this review, we summarize the current information on health-promoting properties of AIF. Reported data evidenced that AIF has a multitherapeutic potential with antiosteoporotic, antioxidant and anti-inflammatory, antimicrobial, anticancer, estrogenic and antiestrogenic, antidiabetic, and neuroprotective properties. However, research on these aspects of AIF is not sufficient and needs to be reevaluated using more appropriate methods and methodology. Further series of studies are needed to confirm these pharmacological effects, and this review should lay the basis for the design of respective investigations. Overall, despite the drawbacks of studies recorded, AIF exhibits a potential as drug candidate.

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“…Genistein (GEN) is a monomer of soy isoflavone, a biologically active substance in legumes. It has many beneficial physiological functions in the human body, including blood fat reduction and bone loss control and also has anti‐cancer and antioxidant properties (Wang et al., 2018). Since the chemical structure of GEN is very similar to oestrogen, it can bind to oestrogen receptors in the body and has a weak oestrogen‐like effect while exerting multiple biological functions (Al‐Nakkas, Markus, Batia, Prozialeck, & Broderick, 2010).…”

Section: Introductionmentioning

confidence: 99%

Effect of genistein on the gene and protein expressions of CXCL–12 and EGR–1 in the rat ovary

Zhang

Chi

Kong

et al. 2020

Animal Physiology Nutrition

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The effect of genistein (GEN) on the gene expression level of stromal cell‐derived factor‐1/CXCL‐12 and early growth response gene‐1 was studied in ovarian tissue of young and initially ageing (early stages in the ageing process) female rats. Forty, young female Sprague Dawley (SD) rats of 2–3 months old (200 ±20 g) and forty, initially ageing female SD rats of 10–12 months (490 ± 20 g) old were selected. According to the weight, rats were divided into control group, low‐dose group (L), medium‐dose group (M) and a high‐dose group (H) and were given 15, 30 and 60 mg/kg GEN respectively. The positive control (Oestrogen) group was given 0.5 mg/kg diethylstilbestrol. The treatment lasted for 30 days. The mRNA expression of C‐X‐C motif chemokine ligand 12 (CXCL‐12) and early growth response factor‐1 (EGR‐1) was measured by real‐time PCR, and protein expression of EGR‐1 was detected by Western blot. When compared to the negative control group (NC), the ovary/body weight ratio in the young rats decreased in the GEN group, but the difference was not significant. Similarly, compared with NC, the ovary/body weight ratio in the initially ageing rats also decreased with the increase in GEN concentration, but the decrease was significant in M and H groups (p < .01). The administration of GEN enhanced both the gene and protein expression levels of CXCL‐12 and EGR‐1 in the ovary. Pearson's correlation analysis showed a synergistic effect between CXCL‐12 and EGR‐1. Thus, we conclude that the effect of GEN on CXCL‐12 and EGR‐1 in the initially ageing group was obvious than that in the younger group.

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Isoflavones from green vegetable soya beans and their antimicrobial and antioxidant activities

Abstract: This study indicated that the isoflavones from soya beans could be considered as potential antioxidants or antimicrobials in the food, cosmetics and pharmaceutical industries. © 2017 Society of Chemical Industry.

Cited by 32 publications

References 15 publications

Potential Anticancer Properties and Mechanisms of Action of Formononetin

Potential Anticancer Properties and Mechanisms of Action of Formononetin

A Pharmacological Overview of Alpinumisoflavone, a Natural Prenylated Isoflavonoid

Effect of genistein on the gene and protein expressions of CXCL–12 and EGR–1 in the rat ovary

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