Isoflavonoids from the heartwood of Pterocarpus marsupium

Mitra, Jayati Chatterjee; Joshi, T.

doi:10.1016/s0031-9422(00)80177-6

Cited by 16 publications

(6 citation statements)

References 5 publications

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“…Hage et al, evaluated the contribution of tannins in Ƴ-secretase inhibitory active of P. erinaceus and found that the activity was not only due to proanthocyanidins which is in accordance to work done by Ouedraogo et al [18]. Pterocarpus species are rich in isoflavonoids [19], terpenoids and related phenolic compounds [20,21,22]. Lupeol, friedelin and epicatechin have been isolated from the stem bark of P. erinaceus [2] and homopterocarpin from its kino [23].…”

Section: Calibrationsupporting

confidence: 55%

Antiradical Activity, Total Phenolic and Flavonoid Content of Extracts from the Stem Bark of Pterocarpus erinaceus

Djouonzo¹,

Ladoh-Yemeda²,

Tchinda³

et al. 2016

SAJB

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In this study, radical scavenging activity, total phenolic and flavonoid contents of hexane, ethyl acetate, nbutanol and methanol extracts of the stem bark of Pterocarpus erinaceus were investigated. Antioxidant activity was assessed by 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2'-azinobis-(3-benzothiazoline-6-sulfonic acid) (ABTS) assay. Total phenolic and flavonoid contents were evaluated with Folin-Ciocalteu and aluminium chloride colorimetric method respectively. Methanol extract showed the best antioxidant activity with the highest total flavonoid content (396.61±3.48 mgE Cat/1g DE) followed by n-butanol extract (263.63±5.44 mgECat/1g DE) and ethyl acetate extract (224.71±7.32 mgECat/1g DE). However, the n-butanol extract showed a highest phenolic content (490.03±4.02 mgEAA/1g DE) than the methanol extract (450.50±1.52 mgEAA/1g DE). These findings showed increase in antioxidant activity directly proportional to increase in extracting solvent's polarity and flavonoid content.

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Section: Calibrationsupporting

confidence: 55%

Antiradical Activity, Total Phenolic and Flavonoid Content of Extracts from the Stem Bark of Pterocarpus erinaceus

Djouonzo¹,

Ladoh-Yemeda²,

Tchinda³

et al. 2016

SAJB

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“…Compositional studies on bijasar have shown this plant to be a good source of polyphenols. P. marsupium contains terpenoids and phenolic compounds: β-sitosterol, lupenol, aurone glycosides, epicatechins, and iso-flavonoids [95, 96]. …”

Section: Indian Medicinal Plants With Antidiabetic Potentialmentioning

confidence: 99%

Traditional Indian Medicines Used for the Management of Diabetes Mellitus

Rizvi

Mishra

2013

Journal of Diabetes Research

117

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Plants have always been a source of drugs for humans since time immemorial. The Indian traditional system of medicine is replete with the use of plants for the management of diabetic conditions. According to the World Health Organization, up to 90% of population in developing countries use plants and its products as traditional medicine for primary health care. There are about 800 plants which have been reported to show antidiabetic potential. The present review is aimed at providing in-depth information about the antidiabetic potential and bioactive compounds present in Ficus religiosa, Pterocarpus marsupium, Gymnema sylvestre, Allium sativum, Eugenia jambolana, Momordica charantia, and Trigonella foenum-graecum. The review provides a starting point for future studies aimed at isolation, purification, and characterization of bioactive antidiabetic compounds present in these plants.

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“…All data were consistent with those in the literature. 21 3-(Benzo[b]thiophen-3-yl)-5,7-dimethoxy-6-hydroxy-4Hchromen-4-one (9). Compound 8 (24.3 mg, 0.061 mmol) was dissolved in anhydrous MeOH (2 mL) and anhydrous THF (1.5 mL).…”

Section: ■ Experimental Sectionmentioning

confidence: 99%

“…For this reaction, 3.1 molar equiv of AlCl 3 was used: 46% yield. All data were consistent with those in the literature …”

Section: Experimental Sectionmentioning

confidence: 99%

Chemical Space Expansion of Flavonoids: Induction of Mitotic Inhibition by Replacing Ring B with a 10π-Electron System, Benzo[b]thiophene

et al. 2022

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Natural products, which are enzymatically biosynthesized, have a broad range of biological activities. In particular, many flavonoids are known to contribute to human health with low toxicity. We previously reported that novel benzo[b]thiophenyl (BT) flavones with a 10π-electron BT ring B replacing the usual 6π-electron phenyl ring showed potent antiproliferative activity against human tumor cell lines. Interestingly, the activity profiles against cell cycle progression of the BTflavones totally changed depending on the combination of substituents at the C-3 and C-5 positions. This finding encouraged an extension of these studies on the impact of BT to related flavonoids, such as chalcones, isoflavones, and aurones. Accordingly, 10 isoflavones, 29 chalcones, and four aurones were synthesized and evaluated for antiproliferative activity against five human tumor cell lines including a multi-drug-resistant cell line. Among these compounds, BT-isoflavone 7, BT-chalcones 48, 52, 57, 66, and 77, and BT-aurone 80 displayed significant antiproliferative effects against all tested tumor cell lines. The structure− antiproliferative activity relationships clearly demonstrated the importance of BT instead of phenyl as ring B for the isoflavone and chalcones, but not the aurones. Flow cytometry and immunocytochemical studies demonstrated that the active BT-flavonoids led to cell cycle arrest at the prometaphase by induction of multipolar spindle formation. The present studies should contribute greatly to the synthesis and functional analysis of biologically active flavonoid derivatives for chemical space expansion.

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Isoflavonoids from the heartwood of Pterocarpus marsupium

Cited by 16 publications

References 5 publications

Antiradical Activity, Total Phenolic and Flavonoid Content of Extracts from the Stem Bark of Pterocarpus erinaceus

Antiradical Activity, Total Phenolic and Flavonoid Content of Extracts from the Stem Bark of Pterocarpus erinaceus

Traditional Indian Medicines Used for the Management of Diabetes Mellitus

Chemical Space Expansion of Flavonoids: Induction of Mitotic Inhibition by Replacing Ring B with a 10π-Electron System, Benzo[b]thiophene

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