Isolamento de 4-hidroxifenil-6-cafeoil-β-L-glicosídeo e b-sitosterol e avaliação
            das atividades antibacteriana, antioxidante e tóxica sobre <i>Artemia salina</i> de <i>Casearia
            javitensis</i>

Núñez, Cecília Veronica; Fachin-Espinar, María Teresa; Souza, Maria Carolina Scheffer de

doi:10.5935/2446-4775.20160021

Revista Fitos

2016

DOI: 10.5935/2446-4775.20160021

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Isolamento de 4-hidroxifenil-6-cafeoil-β-L-glicosídeo e b-sitosterol e avaliação das atividades antibacteriana, antioxidante e tóxica sobre Artemia salina de Casearia javitensis

Cecília Veronica Núñez¹,

María Teresa Fachin-Espinar²,

Maria Carolina Scheffer de Souza³

Abstract: Resumo Casearia javitensis.

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2020

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In vitro antileishmanial activity and phytochemical analysis of Casearia javitensis Kunth (Salicaceae)

Silva¹,

Eiró

Silva-Silva

et al. 2020

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The objective of this study was to carry out phytochemical analysis of the bark extract of Casearia javitensis and to evaluate its antipromastigote activity against Leishmania amazonensis. The ethanol extract (EE) was fractionated in open-column chromatography to obtain the hexane (FrHex), dichloromethane (FrDcm), ethyl acetate (FrAcOET) and methanol (FrMeOH) fractions. The EE and its fractions were analyzed by thin layer chromatography (TLC). FrDcm was analyzed in high performance liquid chromatography with diode array detection (HPLC-DAD). The antipromastigote assay of Leishmania amazonensis and the cytotoxicity test against the acute monocytic leukemia cell line (THP-1) were performed by the MTT colorimetric assay. The phytochemical profile in TLC detected terpenes in all samples. However, in the ultraviolet spectrum (HPLC-DAD) for FrDcm suggested the presence of a phenolic compound. FrHex and FrDcm showed antipromastigote activity (IC50 = 116.6 ± 0.9 and 59.4 ± 1.1 μg mL-1, respectively) and low cytotoxicity (CC50 = 333.4 ± 3.2 and 241.2 ± 1.9 μg mL-1, respectively). The selectivity index for FrDcm was 4.1. We conclude that the FrDcm of C. javitensis has potantial as a leishmanicide, and this activity may be related to the presence of phenolic compound.

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In vitro antileishmanial activity and phytochemical analysis of Casearia javitensis Kunth (Salicaceae)

Silva¹,

Eiró

Silva-Silva

et al. 2020

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show abstract

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Isolamento de 4-hidroxifenil-6-cafeoil-β-L-glicosídeo e b-sitosterol e avaliação das atividades antibacteriana, antioxidante e tóxica sobre Artemia salina de Casearia javitensis

Abstract: Resumo Casearia javitensis.

Cited by 1 publication

References 14 publications

In vitro antileishmanial activity and phytochemical analysis of Casearia javitensis Kunth (Salicaceae)

In vitro antileishmanial activity and phytochemical analysis of Casearia javitensis Kunth (Salicaceae)

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