ISOLASI KUMARIN DARI BIJI PINANG (Areca catechu L.)

Abstract

Coumarin has been isolated from seed of Areca catechu L. an ethyl acetate fraction which needle crystal products at 184 -185°C. Based on thin layer chromatography analysis using n-hexane : acetone (4 : 6) as eluent got Rf 0.6. From elemental analysis, mass spectra, ultraviolet spectra, infra red spectra, nuclear magnetic resonance spectra ( H and C NMR) ,concluded this compound was 7-hidroksi-4-metil coumarine.

Synthesis of 7-(Hydroxy) Coumarin and Its Activity Test As Antibacterial against Staphylococcus aureus and Shigella flexneri

“…The peak in a chemical shift of about 7,50-7,52 ppm shows the protons of H-4 and H-5. This is in line with Ibrahim et al (2007) study on isolation of coumarin from pinang seed (Areca catechu L.), that H-5 uptake appears at a chemical shift 7,51 ppm. Meanwhile, the peak in the chemical shift 9.932 ppm with the singlet appearance is the proton absorption of the -OH group.…”

“…Meanwhile, the peak in the chemical shift 9.932 ppm with the singlet appearance is the proton absorption of the -OH group. According to Ibrahim et al (2007), proton absorption of -OH group is appear at a chemical shift 10.45 ppm with singlet appearance. Thus, it can be concluted that the compound of synthesis result is 7-(hydroxy)coumarin.…”