ISOLASI SENYAWA ANTIOKSIDAN EKSTRAK METANOL KULIT BUAH NAGA MERAH (Hylocereus polyrhizus)

Pratiwi, Dwi Indah; Syarif, Rezki Amriati; Waris, Risda; Faradiba, Faradiba

doi:10.33096/jffi.v6i1.466

Cited by 2 publications

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“…The dragon fruit peel contains various nutrients like vitamin A, vitamin C, vitamin E, alkaloids, terpenoids, flavonoids, thiamine, niacin, pyridoxine, cobalamin, phenolic, carotene, and phytoalbumin (Pratiwi et al, 2019). Another study by Tang et al (2021) reported that dragon fruit peels contain more than 37 phenolic compounds, including chlorogenic acid, caffeic acid, ferulic acid, p-coumaric acid, rutin, and isoquercitrin.…”

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confidence: 99%

In Vitro and In Vivo Antidiarrheal Activity of Dragon Fruit Peels Methanolic Extract

Yosefa,

Tandanu,

Leslie

et al. 2023

Trad.Med.J

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Diarrhea is a global major health problem reported by 2.5 billion cases annually. Diarrhea accounts for 9% of child death worldwide or the second leading cause of death among toddlers. Many local people have used traditional medicine for diarrhea therapy. Dragon fruit is a herbal plant with high vitamins and various nutritious compounds. Therefore, this study determined antidiarrheal activity from dragon fruit peel methanolic extract (Hylocereus polyrhizus). This study was experimental with in vitro and in vivo models. The in vitro model used disc diffusion and microdilution assay against the diarrhea-causing pathogen (Escherichia coli). Meanwhile, the in vivo model used male Wistar rats induced by Castro oil. This study showed that the minimum inhibitory concentration (MIC) and minimum killing concentration (MKC) of dragon fruit peel extract against Escherichia coli were 50 and 100 mg/ml, respectively. The increased dose of dragon fruit peel methanol extract has increased the antidiarrheal index. The highest and lowest antidiarrheal index was found in the dragon fruit methanol extract-3 (76.56%) and dragon fruit methanol extract-1 (43.28%). The dragon fruit peel methanol extract can be proposed as antidiarrhea and antibacterial therapy against the diarrhea-causing pathogen.

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Section: Introductionmentioning

confidence: 99%

In Vitro and In Vivo Antidiarrheal Activity of Dragon Fruit Peels Methanolic Extract

Yosefa,

Tandanu,

Leslie

et al. 2023

Trad.Med.J

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Formulation of Gel Preparations of Ethanol Extract of Indian Strawberry (Duchesnea indica (Jacks.) Focke.)

Mursyid,

Waris,

W. Ilham

et al. 2023

RJPDFT

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The anti-inflammatory activity of Indian strawberry leaves is 0.31 percent DAI. For the treatment of inflammation, gel formulations are selected as effective penetration agents. The purpose of this work was to manufacture and test a pharmaceutically stable gel formulation of ethanol extract of Indian strawberry (Duchesnea indica (Jacks.) Focke] leaf with anti-inflammatory properties. This experimental study approach involved developing four formulas: F1 with 3% NaCMC, F2 with 4% NaCMC, F3 with 8% HPMC, and F4 with 9% HPMC. Then, the next test was evaluate the physical stability of the formulation using the following test parameters: organoleptic, pH, homogeneity, spreadability, and viscosity at 5°C and 35°C. The organoleptic test revealed that there was no difference between the four formulae in the color, odor, and consistency series. Each of the pH formulae that passed the pH test were suitable for topical application to the skin. For the homogeneity test all formulas are homogeneous. The best dispersion for the dispersion test was found in formulas 2, 3, and 4. Based on the rheogram, F1, F2, F3, and F4 had pseudoplastic flow characteristics. According to the results of the research conducted, the ethanol extract of Indian strawberry leaves can be formed into gel formulations based on HPMC and NaCMC. The gel formulation formula for ethanol extract of Indian strawberry leaves is pharmaceutically stable.

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ISOLASI SENYAWA ANTIOKSIDAN EKSTRAK METANOL KULIT BUAH NAGA MERAH (Hylocereus polyrhizus)

Cited by 2 publications

References 1 publication

In Vitro and In Vivo Antidiarrheal Activity of Dragon Fruit Peels Methanolic Extract

In Vitro and In Vivo Antidiarrheal Activity of Dragon Fruit Peels Methanolic Extract

Formulation of Gel Preparations of Ethanol Extract of Indian Strawberry (Duchesnea indica (Jacks.) Focke.)

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