Isolated flavonoids from Ficus racemosa stem bark possess antidiabetic, hypolipidemic and protective effects in albino Wistar rats

Keshari, Amit K; Kumar, G.; Kushwaha, Priya Singh; Bhardwaj, Monika; Kumar, Pranesh; Rawat, Atul; Kumar, Dinesh; Prakash, Anand; Ghosh, Balaram; Saha, Sudipta

doi:10.1016/j.jep.2016.02.004

Cited by 81 publications

(41 citation statements)

References 30 publications

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“…Flavonoids can be used as antidiabetic [26] and have been introduced as hypolipidemic and antioxidant for rats that have been STZ-induced [33]. Tannins from mangrove plant have stronger antioxidant activity compared to BHT standard.…”

Section: Yield and Phytochemical Contentmentioning

confidence: 99%

The Effect of Heating Temperature on Inhibitory Activity of Mangrove Rhizophora Mucronata Fruit Extract Toward Α-Glucosidase

Hardoko

Sasmito

Puspitasari

et al. 2018

Asian J Pharm Clin Res

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Objectives: The aim of this research was to determine the effect of heating temperature of mangrove Rhizophora mucronata fruit extract toward its inhibition activity of α-glucosidase. Methods:Research method used was an experimental method with the treatment of heating temperature (70°C, 80°C, 90°C, and 100°C) of crude tannin extract of mangrove R. mucronata fruit on inhibition activity toward α-glucosidase.Results: IC 50 of unheated extract and extracts that were heated at 70°C, 80°C, 90°C, and 100°C are adalah 3.38 ppm, 2.79 ppm, 2.97 ppm, 3.19 ppm, and 3.52 ppm, respectively. Heating until 100°C only decreased its inhibition activity of α-glucosidase of about 3.87% compared to unheated extract. Mangrove R. mucronata fruit extract contains phytochemical compounds, i.e., alkaloids, saponin, flavonoids, tannin, and terpenoids. IC 50 of this extract is lower compared to IC 50 of acarbose (antidiabetic medicine), which as IC 50 value of 13.27 ppm. Conclusion:Mangrove R. mucronata fruit extract is quite heat resistant and is potential to be an antidiabetic functional food.

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Section: Yield and Phytochemical Contentmentioning

confidence: 99%

The Effect of Heating Temperature on Inhibitory Activity of Mangrove Rhizophora Mucronata Fruit Extract Toward Α-Glucosidase

Hardoko

Sasmito

Puspitasari

et al. 2018

Asian J Pharm Clin Res

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“…[174][175][176][177][178][179][180] Due to their higher potential activity in many chronic diseases, they are widely used to prepare novel beverages. However, due to the limited oral bioavailability and stability of those compounds, alternative nano-based delivery technologies have been recently studied to assess their efficacy.…”

Section: Nano-naringeninmentioning

confidence: 99%

Phytobioactive compound-based nanodelivery systems for the treatment of type 2 diabetes mellitus – current status

Ganesan¹,

Arulselvan²,

Choi³

2017

IJN

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Type 2 diabetes mellitus (T2DM) is a major chronic disease that is prevalent worldwide, and it is characterized by an increase in blood glucose, disturbances in the metabolism, and alteration in insulin secretion. Nowadays, food-based therapy has become an important treatment mode for type 2 diabetes, and phytobioactive compounds have gained an increasing amount of attention to this end because they have an effect on multiple biological functions, including the sustained secretion of insulin and regeneration of pancreatic islets cells. However, the poor solubility and lower permeability of these phyto products results in a loss of bioactivity during processing and oral delivery, leading to a significant reduction in the bioavailability of phytobioactive compounds to treat T2DM. Recently, nanotechnological systems have been developed for use as various types of carrier systems to improve the delivery of bioactive compounds and thus obtain a greater bioavailability. Furthermore, carrier systems in most nanodelivery systems are highly biocompatible, with nonimmunologic behavior, a high degree of biodegradability, and greater mucoadhesive strength. Therefore, this review focuses on the various types of nanodelivery systems that can be used for phytobioactive compounds in treating T2DM with greater antidiabetic effects. There is also additional focus on improving the effects of various phytobioactive compounds through nanotechnological delivery to ensure a highly efficient treatment of type 2 diabetes.

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“…Flavonoids are a diverse class of polyphenolic phytochemicals found in various vegetables and fruits, and provide color, aroma, flavor, and nutritional and health benefits (Karakaya, Sedef, 1999). Many flavonoids extracted from plants have been reported to show various biological effects, including anticancer, antioxidant, antibacterial, anti-inflammatory, and antidepressant effects (Ahmed, Khan, Saeed, 2015;Xie et al, 2014;Kulbacka et al, 2016;Yao et al, 2014;Keshari et al, 2016). Apigenin (5,7,4´-trihydroxyflavonoid; Figure 1), a bioflavonoid widely found in citrus fruits, has been found to exert a variety of pharmacological effects, Page 2 / 10 including antibacterial, anticancer, and antiproliferative effects (Banerjee et al, 2015;Liu et al, 2013;Eumkeb, Chukrathok, 2013;Choi et al, 2010;Turktekin et al, 2011;Ruivo et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Synthesis and antibacterial activity of a series novel 5,7-diisoprenyloxyflavone derivatives

Jin

Xia

et al. 2020

Braz. J. Pharm. Sci.

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In the present study, a series of novel 5,7-diisoprenyloxyflavone derivatives were designed, synthesized, and evaluated for their antibacterial activity. Most of these compounds displayed significant antibacterial effects against Gram-positive bacteria, especially against strains of multidrug-resistant clinical isolates . Compounds 4c, 4g, 4i, 4j, 4k, 4l, 4n, 4q and 4t showed high levels of antimicrobial activity against Staphylococcus aureus RN4220 with minimum inhibitory concentrations of 4.0-20 μM. Compound 4k showed the most potent activity among these compounds against all multidrug-resistant clinical isolates tested. Unfortunately, none of the compounds were active against Gram-negative bacteria at the doses of 24-164 μM.

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Isolated flavonoids from Ficus racemosa stem bark possess antidiabetic, hypolipidemic and protective effects in albino Wistar rats

Cited by 81 publications

References 30 publications

The Effect of Heating Temperature on Inhibitory Activity of Mangrove Rhizophora Mucronata Fruit Extract Toward Α-Glucosidase

The Effect of Heating Temperature on Inhibitory Activity of Mangrove Rhizophora Mucronata Fruit Extract Toward Α-Glucosidase

Phytobioactive compound-based nanodelivery systems for the treatment of type 2 diabetes mellitus – current status

Synthesis and antibacterial activity of a series novel 5,7-diisoprenyloxyflavone derivatives

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Isolated flavonoids from Ficus racemosa stem bark possess antidiabetic, hypolipidemic and protective effects in albino Wistar rats

Cited by 81 publications

References 30 publications

The Effect of Heating Temperature on Inhibitory Activity of Mangrove Rhizophora Mucronata Fruit Extract Toward Α-Glucosidase

The Effect of Heating Temperature on Inhibitory Activity of Mangrove Rhizophora Mucronata Fruit Extract Toward Α-Glucosidase

Phytobioactive compound-based nanodelivery systems for the treatment of type 2 diabetes mellitus &ndash; current status

Synthesis and antibacterial activity of a series novel 5,7-diisoprenyloxyflavone derivatives

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Product

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Phytobioactive compound-based nanodelivery systems for the treatment of type 2 diabetes mellitus – current status