Isolated hemimegalencephaly in an adult

Rao, Janapareddy Vijaya Bhaskara; Vengamma, B; Naveen, Thota; Ramakrishna, Gajula

doi:10.4103/0976-3147.140019

Cited by 2 publications

(2 citation statements)

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“…Thus in some patients surgical treatment is not indicated, or previously they underwent hemispherectomy due to DRE (Table 1). Three cases of HME in adults with DRE beginning in infancy have been previously reported [18], [19], [20]. Two patients became seizure free with medical management.…”

Section: Discussionmentioning

confidence: 95%

“…Syndromic HME includes hypomelanosis of Ito, linear sebaceous nevus syndrome, epidermal nevus. EPC: epilepsia partialis continua; TMS: transcranial magnetic stimulation; NR: not reported.PaperNumber of adult casesAge at evaluation (years)Epilepsy duration (years)Cognitive impairmentHemiparesisSeizuresRefractory epilepsyHemispherectomySyndromicCommentsWu et al [7]518–3416–34None (1); Mild (1); Severe (3)Y (5)Y (5)Y (4)Y (2)Y (4)Ohtsuka et al [21]13030MildYYYNNEPCFusco et al [22]1195NNYNNNBeaulieu-Boire et al [25]1191NYYNNNSingh et al [19]1260.5MildYYNNNRao et al [18]13029ModerateYYNNNTinkle et al [1]129NRYYYNRNYChrastina et al [20]11818SevereYYYNNVNS implantationCivardi et al [26]1264NNYNNNTMS studyBarkovich et al [24]233–41NRNRNRNRNRNRNRImaging studySchramm et al …”

Section: Discussionmentioning

confidence: 99%

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Evolution of epilepsy in hemimegalencephaly from infancy to adulthood: Case report and review of the literature

Ikeda

Mirsattari

2017

Epilepsy & Behavior Case Reports

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Hemimegalencephaly (HME) is a rare disorder of cortical development with overgrowth of one cerebral hemisphere. Patients have intellectual delay, hemiparesis and severe epilepsy. Drug-resistant epilepsy is often treated with a hemispherectomy. We review the literature on HME natural history and report a 26-year-old man with HME who did not undergo hemispherectomy in childhood with recurrent focal convulsive or non-convulsive status epilepticus.Few patients with HME have been followed into adulthood. Reported adult cases have milder epilepsy or underwent hemispherectomy in childhood. Patients surviving to adulthood have poor outcomes, regardless of treatment method, although seizure burden is improved with hemispherectomy.

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Section: Discussionmentioning

confidence: 95%