Isolated Port-Site Metastases After Minimally Invasive Hysterectomy for Endometrial Cancer

Grant, Jonathan D.; Garg, Amit; Gopal, Ramesh; Soliman, Pamela T.; Jhingran, Anuja; Eifel, Patricia J.; Klopp, Ann H.

doi:10.1097/igc.0000000000000424

Cited by 14 publications

(14 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Additionally, a case series of PSM after minimally invasive hysterectomy for endometrial cancer at MD Anderson Cancer Center demonstrated excellent response with high rates of local control following surgery and adjuvant radiotherapy (Grant et al, 2015). However, this case series was small, including only 7 patients, and there was no comparison group that received surgery without radiation.…”

Section: Discussionmentioning

confidence: 99%

Isolated port site recurrence of node-negative clinical stage IB1 cervical adenocarcinoma

Deshmukh

McAdow

Black

et al. 2017

Gynecologic Oncology Reports

View full text Add to dashboard Cite

IntroductionPort site metastasis after laparoscopic surgery for cervical cancer is a rare phenomenon.MethodsWe present a case report of isolated port site recurrence 4 years following laparoscopic surgery in a patient with node-negative, clinical stage IB1 cervical adenocarcinoma.ResultsA 44 year-old woman presented with a necrotic cervical lesion. A biopsy of the mass revealed invasive endocervical adenocarcinoma. She underwent a robotic-assisted radical hysterectomy, bilateral salpingectomy, and pelvic lymph node dissection with bilateral oophoropexy. All lymph nodes were placed in an Endocatch bag prior to removal via the 12 mm assistant port. There was no clinical evidence of metastatic disease and final pathology revealed negative surgical margins and lymph nodes. Four years later, she re-presented with a soft tissue mass in her abdominal wall underlying the site of the prior laparoscopic assistant port. This was confirmed by transcutaneous biopsy to be metastatic adenocarcinoma of endocervical origin. Further work-up revealed no other evidence of metastatic disease. The recurrence was excised and all margins were negative.ConclusionThis is the first case report describing an isolated port site recurrence in a patient who underwent robotic-assisted laparoscopic surgery for early-stage cervical adenocarcinoma with negative margins and negative lymph nodes. The mechanism underlying this isolated recurrence remains unknown.

show abstract

Section: Discussionmentioning

confidence: 99%

Isolated port site recurrence of node-negative clinical stage IB1 cervical adenocarcinoma

Deshmukh

McAdow

Black

et al. 2017

Gynecologic Oncology Reports

View full text Add to dashboard Cite

show abstract

“…Robot-assisted laparoscopy has altered the landscape of minimally invasive gynecologic surgery. [3][4][5] Expanded use of laparoscopic methods for different types of cancer has met with greater awareness of their potential complications.…”

Section: Introductionmentioning

confidence: 99%

“…6,7 PSM is defined as tumor-cell implantation at the site of trocar insertion after laparoscopic resection of a malignant tumor. 5,8,9 PSM has been reported to occur at 1%-2% of all laparoscopic procedures in gynecologic surgery. 3,10 Isolated port-site metastasis (iPSM; also known as "solitary port-site metastasis") denotes tumor recurrence at trocar sites without evidence of concomitant metastasis.…”

Section: Introductionmentioning

confidence: 99%

“…11,12 Conversely, PSM with simultaneous metastasis in other locations ("non-isolated PSM") is usually regarded as a part of systemic recurrence. 5 It has not been demonstrated that all patients with PSM carry a worse prognosis, but some studies have suggested that the PSM associated with multilocal recurrence has an adverse impact upon survival. 13,14 Management of PSM with multiple metastases follows the general principles of treating a systematic recurrence, but iPSM treatment is controversial.…”

Section: Introductionmentioning

confidence: 99%

“…Surgical excision alone, surgical excision and adjuvant chemoradiotherapy, or radiotherapy alone for iPSM management have been reported, but the outcomes have been heterogeneous. 5,15 Given the small study cohorts and heterogeneous outcomes of management, guidelines for iPSM treatment have been lacking. The validity of preventive actions to reduce PSM prevalence has not been demonstrated.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

<p>The Pathogenesis and Prevention of Port-Site Metastasis in Gynecologic Oncology</p>

Gao¹,

Guo²,

Wang³

2020

CMAR

View full text Add to dashboard Cite

Port-site metastasis (PSM) is a specific and challenging complication of laparoscopic gynecologic oncologic procedures. Research has demonstrated that PSM is associated with significant morbidity and poor outcome. The exact pathogenesis of PSM in gynecologic patients is not clear. Several preventive measures of PSM have been addressed in the relevant literature, and novel approaches to prevent this uncommon complication keep emerging. In this review, we summarized the potential mechanisms of PSM and discuss the controversies and merits of proposed preventive measures of PSM in gynecologic oncology. We undertook a literature search using the Medline database to identify studies on the pathogenesis and prevention of laparoscopic PSM. Hypotheses of PSM pathogeneses center on the immune response, pneumoperitoneum, wound contamination, and surgical method. Cogent evidence of effective prevention of PSM after laparoscopic surgery is lacking. Traditional preventive actions such as irrigation and tumor manipulation should be taken individually. Insufflation of hyperthermic CO 2 and humidified CO 2 leads to a better outcome in patients with a malignant tumor who undergo a laparoscopic procedure compared with normal CO 2 pneumoperitoneum. Port-site resection shows no advantage in survival and results in more wound events. PSM prevention plays a crucial part in the overall care of patients with gynecologic malignancies who undergo laparoscopic procedures.

show abstract

Port Site Metastases of Carcinoma Endometrium: Case Report and Literature Review

Shanmugam

Dharan

Aravind

2023

Indian J Gynecol Oncolog

View full text Add to dashboard Cite

Isolated Port-Site Metastases After Minimally Invasive Hysterectomy for Endometrial Cancer

Cited by 14 publications

References 24 publications

Isolated port site recurrence of node-negative clinical stage IB1 cervical adenocarcinoma

Isolated port site recurrence of node-negative clinical stage IB1 cervical adenocarcinoma

<p>The Pathogenesis and Prevention of Port-Site Metastasis in Gynecologic Oncology</p>

Port Site Metastases of Carcinoma Endometrium: Case Report and Literature Review

Contact Info

Product

Resources

About