Isolated Rare Urethral Metastasis From Primary Lung Adenocarcinoma: Case Report and Literature Review

Abstract

Background: Lung adenocarcinoma is a common respiratory malignancy, however urethral metastasis of lung adenocarcinoma has not yet been reported. This study aims to present a rare case of isolated urethral metastasis in a male patient with a history of primary lung adenocarcinoma. Case Presentation: A 69 year-old male patient was admitted complaining of dysuria and nocturia for 3 months, with a history of lung adenocarcinoma after surgery. The patient was diagnosed as benign prostatic hyperplasia (BPH) and received holmium laser enucleation of the prostate, an effective transurethral procedure to treat bladder outflow obstruction due to BPH. Four months after surgery for BPH, the patient had no improvement in symptoms and continued to complain of dysuria and perineum pain. An MRI of the pelvis indicated posterior urethral mass without any regional lymphadenopathy or other sites of lesion. Urethrocystoscopy found the mass in the membranous urethra near the verumontanum, and pathology combined with immunohistochemical staining confirmed the isolated urethral metastasis of lung adenocarcinoma. The further therapeutic regimen consisting of chemotherapy (pemetrexed combined with nedaplatin) and bevacizumab was well-tolerated, and obviously relieved the patient from dysuria and perineum pain. Conclusion: This study reported the first case of isolated rare urethral metastasis from primary lung adenocarcinoma and underlined the necessity for clinicians to remain vigilant to metastasis during follow-up of primary cancer.

The summary and preliminary analysis of clinical and PET/CT features of patients with intestinal metastasis of primary lung cancer

“…The most common site of metastasis is the small intestine, with isolated cases of large intestine and anus also reported (14). Since lung cancer progresses to intestinal metastasis without apparent symptoms, most cases are detected by examination to exclude common site metastasis (15). It is found that a small percentage of intestinal obstruction is due to intestinal metastasis (16).…”

A Robust Signature Based on Autophagy‐Associated LncRNAs for Predicting Prognosis in Lung Adenocarcinoma

“…Although various therapeutic approaches have been introduced for LUAD, there were still no obvious improvements in ameliorating unfavorable prognoses, especially in patients with metastatic disease. Metastases of LUAD to the nervous system, bone, liver, adrenal gland and even urethra tend to indicate poor therapeutic outcomes, and only some selected cases may benefit from systematic therapy [6][7][8]. The TNM staging system provides a relatively reliable predictive model for prognosis and remains the most frequently applied predictor of survival [9].…”

Isolated urethral metastasis from appendiceal mucinous adenocarcinoma

“…The literature on urethral metastasis is limited to case reports and a few small case series, with most publications focusing on histopathologic and clinical presentations rather than MRI findings. The scant reports of urethral metastasis have described spread from primary cancers such as colonic adenocarcinoma [6][7][8], prostate adenocarcinoma [9], melanoma [10], high grade ovarian serous cell carcinoma [11], renal clear cell carcinoma [12], and primary lung adenocarcinoma [13], among others [14]. In women, the most common locations of urethral metastasis involved either the external meatus or the whole urethra [1,5,6,8,10,15,16].…”