Isolated Relapse of Acute Lymphoblastic Leukemia in the Epididymis: A Rare Sanctuary Site

Bourne, Andrew E.; Wayment, Robert O.; Tarter, Thomas H.; Hemmer, Patrick H. J.

doi:10.1200/jco.2009.23.8014

Cited by 4 publications

(5 citation statements)

References 5 publications

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“…Relapses in leukemia occur most commonly in the bone marrow followed by CNS and the testes. Other extramedullary sites reported in the literature include the breast, bone, skin and subcutaneous tissue, pancreas, prostate, epididymis, head and neck, uterus and adnexa, gut, kidney, eye and lungs [ 5 – 9 ].…”

Section: Discussionmentioning

confidence: 99%

Bone relapse in T-lineage acute lymphoblastic leukemia in a child

Meena

Ahad

Gupta

et al. 2018

Oxford Medical Case Reports

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Acute lymphoblastic leukemia (ALL) is the most common malignancy in children. T-cell ALL accounts for 10–15% of cases. ALL can rarely relapse in unusual extramedullary sites like bone. Hereby, we report a case of 7-year-old male child who was being treated for T-cell ALL and then presented with left arm swelling. This swelling was initially thought to be a bone tumor but later it was found to be infiltrated by leukemic blasts. We reviewed all previous cases and suggest that in a patient of ALL presenting with a bone swelling during or after completion of therapy, one should suspect of bone relapse.

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Section: Discussionmentioning

confidence: 99%

Bone relapse in T-lineage acute lymphoblastic leukemia in a child

Meena

Ahad

Gupta

et al. 2018

Oxford Medical Case Reports

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“…Effective application of chemotherapy has reduced testicular relapse down to 0-3 percent. [3][4][5] Isolated relapse of ALL in the epididymidis is extremely rare. As reported in the literature, patients with isolated relapse of ALL in the epididymis present with painful scrotal emergency similar to epididymitis or testicular torsion or as is the case with our patient, painless swelling resembling a tumoral mass can be observed.…”

Section: Discussionmentioning

confidence: 99%

“…As reported in the literature, patients with isolated relapse of ALL in the epididymis present with painful scrotal emergency similar to epididymitis or testicular torsion or as is the case with our patient, painless swelling resembling a tumoral mass can be observed. [5][6][7] Mazzu et al [8] observed that hypervascularity was associated with every case of testicular leukemic or lymphoblastic infiltration Diffuse hypervascularity detected on ultrasonograms supports leukemic or lymphoblastic infiltration.…”

Section: Discussionmentioning

confidence: 99%

Isolated relapse of a lymphoblastic leukemia T cell precursor in the epididymis

Akay

Kaya

Ergin

et al. 2014

Turkish Journal of Urology

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A 41-year-old man who had otherwise asymptomatic right scrotal swelling presented to our urology clinic. He had been diagnosed with T cell precursor lymphoblastic leukemia/lymphoma 2 years previously. On examination, his right epididymis was enlarged. A regular, homogeneous, slightly hypoechoic solid mass was observed at the right caput epididymis. This testicular mass measured approximately 7×11×12 mm. Leukemia and lymphoma appear in a variety of locations throughout the body, but an isolated relapse involving the epididymis is rare. Epididymectomy was performed which naturally removed the patient's right-sided sperm duct system. Especially in the younger age group epididymal masses can lead to fertility problems.

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“…Relapses in leukemia occur most commonly in the bone marrow followed by CNS and the testes. Other extra medullary sites reported in literature include the breast, bone, skin and subcutaneous tissue, pancreas, prostate, epididymis, head and neck, uterus and adnexa, gut, kidney, eye, and lungs [4][5][6][7][8].…”

Section: Discussionmentioning

confidence: 99%

Bone Relapse in T Lineage Acute Lymphoblastic Leukemia in a Child: A Case Report and Review of Literature

Meena¹

2017

Arch Med

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Acute lymphoblastic leukemia (ALL) is the most common malignancy in children. T-cell ALL accounts for 10% to 15% of cases. Acute lymphoblastic leukemia can rarely relapse in unusual extra medullary sites like bone. Hereby, we report a case of 7-years old male child presented with left arm swelling, initially confused with bone tumor but later found to be infiltration by leukemic blasts. We reviewed all previous cases and suggest that in a patient of ALL presenting with a bone swelling during or after completion of therapy, one should suspect of bone relapse.

show abstract

Isolated Relapse of Acute Lymphoblastic Leukemia in the Epididymis: A Rare Sanctuary Site

Cited by 4 publications

References 5 publications

Bone relapse in T-lineage acute lymphoblastic leukemia in a child

Bone relapse in T-lineage acute lymphoblastic leukemia in a child

Isolated relapse of a lymphoblastic leukemia T cell precursor in the epididymis

Bone Relapse in T Lineage Acute Lymphoblastic Leukemia in a Child: A Case Report and Review of Literature

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