Isolation and Characterization of a Glycopeptide from Mucinous Carcinoma of Human Stomach*

Kimoto, Eiji; Kuranari, Takayo; Masuda, Hiroshi; Takeuchi, Mutsuya

doi:10.1093/oxfordjournals.jbchem.a128808

Cited by 16 publications

(3 citation statements)

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“…The increased secretion of acidic glycoproteins is demonstrated by the high values of sialic acid in the gastric juice [3], After administration of tracer sulfate the radioactivity was found higher in the tumor than in the non cancerous gastric tissue [6]. At last a glycopeptide rich in sialic acid and in sulfate was isolated from the tumor but not from the normal mucosa [13]. At any case, the specific tumoral sulfated muco-substances are mixed with the salivary and esophageal molecules in the gastric secretions.…”

Section: Sulfated Muco-substances In the Diseased Stomachmentioning

confidence: 99%

Sulfated Muco-Substances and Gastric Diseases

Lambert¹,

André²

1972

Digestion

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Section: Sulfated Muco-substances In the Diseased Stomachmentioning

confidence: 99%

Sulfated Muco-Substances and Gastric Diseases

Lambert¹,

André²

1972

Digestion

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“…It contained much larger amount of sialic acid and sulfate group than those of the gastric mucosal glycoprotein. The former might belong to a sialomucin while the latter will be a fucomucin, as classified in our previous paper (7).…”

Section: Resultsmentioning

confidence: 87%

Immunofluorescent Staining of Mucosal Glycoprotein of Human Intestinal Mucosa

Kawasaki

Imasato

Nakayama

et al. 1972

Acta Histochem. Cytochem

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“…By means of histochemical methods, sulfated material was observed in gastric tumors, but not in normal gastric mucosa (Lev, 1966). Kimoto et al (1968) extracted from gastric tumors a sulfated glycopeptide absent from normal tissue. These observations raised the problem of the origin of such sulfated substances.…”

mentioning

confidence: 99%

Isolation of a sulfated glycopeptidic antigen from human gastric tumors: Its localization in normal and cancerous gastrointestinal tissues

Bara

Paul-Gardais

Loisillier

et al. 1978

Intl Journal of Cancer

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A sulfated glycopeptidic antigen (SGA) was purified from papain-digested cancerous human gastric mucosa. The amino acid composition of this antigen was characterized by a high percentage of threonine and proline. Serine was present in small quantities and aromatic amino acids were absent. The amount of sulfate present was evaluated at 7.5%. Fucose, galactose, N-acetyl glucosamine, N-acetyl galactosamine and sialic acid were found to be present in the molar ratio 1:4.6:3.0:6.2:5.0. With immunofluorescence techniques, a rabbit antiserum against the sulfated glycopeptide stained adult gastric mucosa when this tissue had intestinal metaplasia and stained the goblet cells of the intestinal tract (small and large intestines). About 50% of colonic carcinomas and some gastric carcinomas contained SGA. This sulfated antigen was present in well-differentiated tumors and there was a good correlation between tumoral acid mucous secretory activity and the SGA positivity.

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Isolation and Characterization of a Glycopeptide from Mucinous Carcinoma of Human Stomach*

Cited by 16 publications

References 0 publications

Sulfated Muco-Substances and Gastric Diseases

Sulfated Muco-Substances and Gastric Diseases

Immunofluorescent Staining of Mucosal Glycoprotein of Human Intestinal Mucosa

Isolation of a sulfated glycopeptidic antigen from human gastric tumors: Its localization in normal and cancerous gastrointestinal tissues

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