Isolation and Characterization of Acetylcholinesterase Inhibitors from Piper longum and Binding Mode Predictions

Khatami, Zakie; Herdlinger, Sonja; Sarkhail, Parisa; Zehl, Martin; Kaehlig, Hanspeter; Schuster, Daniela; Adhami, Hamid-Reza

doi:10.1055/a-1199-7084

Cited by 9 publications

(4 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For instance, the ethyl acetate extract of P. nigrum exhibited efficient inhibition percentages of 61.5% against AChE and 90.6% against BChE at 100 μg/mL, whereas from the 21 isolated piperamides, piperine was the most potent inhibitor with IC50 values of 63.16 μg/mL in AChE and 25.11 μg/mL in BChE, respectively [43]. On the other hand, the dichloromethane extract of P. longum, as well as piperine (IC50 = 0.32 mM), pipercide (IC50 = 0.61 mM) and guineensine (IC50 = 1.61 mM), were shown to be able to inhibit AChE [44]. In another study, the methanolic extracts obtained from the fruits of P. nigrum and P. retrofractum displayed IC50 values of 11.13 and 14.08 μg/mL against AChE, respectively [45].…”

Section: Anti-cholinesterase Activitymentioning

confidence: 96%

Insights into the Phytochemical and Multifunctional Biological Profile of Spices from the Genus Piper

et al. 2021

View full text Add to dashboard Cite

Piper spices represent an inexhaustible reservoir of bioactive compounds that may act as drug leads in natural product research. The aim of this study was to investigate a series of methanolic fruit extracts obtained from P. nigrum (black, green, white and red), P. longum and P. retrofractum in comparative phytochemical and multi-directional biological (antimicrobial, antioxidant, anti-enzymatic and anti-melanogenic) assays. The metabolite profiling revealed the presence of 17 piperamides, with a total content of 247.75–591.42 mg piperine equivalents/g. Among the 22 tested microorganism strains, Piper spices were significantly active (MIC < 0.1 mg/mL) against the anaerobes Actinomyces israelii and Fusobacterium nucleatum. The antioxidant and anti-enzymatic activities were evidenced in DPPH (10.64–82.44 mg TE/g) and ABTS (14.20–77.60 mg TE/g) radical scavenging, CUPRAC (39.94–140.52 mg TE/g), FRAP (16.05–77.00 mg TE/g), chelating (0–34.80 mg EDTAE/g), anti-acetylcholinesterase (0–2.27 mg GALAE/g), anti-butyrylcholinesterase (0.60–3.11 mg GALAE/g), anti-amylase (0.62–1.11 mmol ACAE/g) and anti-glucosidase (0–1.22 mmol ACAE/g) assays. Several Piper extracts (10 μg/mL) inhibited both melanin synthesis (to 32.05–60.65% of αMSH+ cells) and release (38.06–45.78% of αMSH+ cells) in αMSH-stimulated B16F10 cells, partly explained by their tyrosinase inhibitory properties. Our study uncovers differences between Piper spices and sheds light on their potential use as nutraceuticals or cosmeceuticals for the management of different diseases linked to bacterial infections, Alzheimer’s dementia, type 2 diabetes mellitus or hyperpigmentation.

show abstract

Section: Anti-cholinesterase Activitymentioning

confidence: 96%

Insights into the Phytochemical and Multifunctional Biological Profile of Spices from the Genus Piper

et al. 2021

View full text Add to dashboard Cite

show abstract

“…(Piperaceae) piperine (Khatami et al, 2020) Hedyotis spread Spreng. (Rubiaceae) 3,4-epoxyclerodan-13E-en-15-oic acid, 5α,8α(2oxokolavênico acid), 3,4-dihydroxyclerodan-13Zen-15-oic acid (Cavin et al, 2006) Stephania Venous (Blume) Spreng.…”

Section: Carissa Carandas L (Apocynaceae)mentioning

confidence: 99%

Bibliometric study of chemical compounds based on medicinal plants anti-Alzheimer

Fernandes¹,

Dalarmi²,

Montrucchio³

et al. 2023

Global Health Trends and Perspectives in Health Sciences

View full text Add to dashboard Cite

Alzheimer's disease is a chronic neurodegenerative condition that affects mainly memory and other cognitive functions. Interest in finding treatments effective for this disease has increased in recent years, leading to the investigation of the use of medicinal plants and isolated compounds as possible therapeutic treatments. This study aims to identify research on plants and isolated compounds that demonstrate efficacy in the treatment of markers of Alzheimer's pathology over the years. To achieve this goal, we performed a literature review using methods quantitative, which allows us to identify trends, authors, journals and research areas most relevant to the topic. We collect data and submit them to quantitative analyzes to get an overview of the state of the art in this particular field. The methodology employed included the use of bibliometric software for surveys quantitative surveys and the Rayyan platform for qualitative surveys. The quantitative analysis covered the leadership of the studies, the power analysis used in the articles and the identification of predominant themes. While in the qualitative analysis, we focused on the experimented plants that cause anti-Alzheimer's effects, with a focus on the isolated chemical compounds responsible by pharmacological action. As a result of the quantitative analysis, we found a growing interest in research on plants and Alzheimer's disease. Since the first publications at the beginning of the 2000s to the present day, there has been a steady increase in the number of studies, reflecting a significant progress has been made in understanding the possible benefits of plants in the treatment and in preventing this debilitating disease. Our findings highlight the continuing importance of research in this area, which may provide promising therapeutic alternatives to face the challenges posed by the disease of Alzheimer's. Through this bibliographic research, we hope to contribute to the advancement of scientific knowledge and for the development of more effective therapeutic approaches and accessible for this complex condition.

show abstract

“…Pre-clinical Traditional medicines have treated memory loss with the fruits of the Piper longum tree. [31] 2 Bala (Sida cordifolia)…”

Section: Essential Oil Alkaloidmentioning

confidence: 99%

Role of Panchbhautika Taila Nasya in Socio-Behavioral Disorders - Ayurveda Perspective

Piyushika Sharma,

Rahul Katkar,

Shrinidhi Kumar K

2023

Int J Ayu Pharm Res

View full text Add to dashboard Cite

Socio-behavioural disorders have a profound impact on affected individuals lives and society at large. The conventional treatment for child and adolescent psychiatric disorders often involves psychopharmacology, which may be associated with adverse side effects. Ayurveda, an ancient traditional system of medicine, offers a multidimensional therapeutic strategy to address these disorders. According to the classics, the unstable status of Mana, Indriya and Atma leads to many socio-behavioural disorders. To address this challenge, Ayurveda have given a multidimensional approach including Medhya rasayanas, Panchakarma procedures like Nasya and nonmedical treatment including Achara rasayana (rejuvenation through the right code of conduct) and Satvavajaya chikitsa. Panchbhautika taila nasya is mentioned in Kashyap samhita for increasing the strength of sensory organs This research article explores the efficacy of Ayurvedic Nasya therapy, particularly Panchbhautik Taila Nasya, as a potential intervention to enhance cognitive function and mitigate socio-behavioural abnormalities.

show abstract

Isolation and Characterization of Acetylcholinesterase Inhibitors from Piper longum and Binding Mode Predictions

Cited by 9 publications

References 30 publications

Insights into the Phytochemical and Multifunctional Biological Profile of Spices from the Genus Piper

Insights into the Phytochemical and Multifunctional Biological Profile of Spices from the Genus Piper

Bibliometric study of chemical compounds based on medicinal plants anti-Alzheimer

Role of Panchbhautika Taila Nasya in Socio-Behavioral Disorders - Ayurveda Perspective

Contact Info

Product

Resources

About