Isolation and characterization of an antimalarial agent of the neem tree Azadirachta indica

Khalid, Sami A.; Duddeck, H.; González‐Sierra, Manuel

doi:10.1021/np50065a002

Cited by 159 publications

(99 citation statements)

References 8 publications

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“…This suggested the presence of the g-lactone group attached to C-17 in 12 which was supported by the 13 ) and molecular modeling 30) supported the relative configuration of 12.…”

Section: T Akihisa T Noto a Takahashi Et Almentioning

confidence: 69%

Melanogenesis Inhibitory, Anti-Inflammatory, and Chemopreventive Effects of Limonoids from the Seeds of Azadirachta indicia A. Juss. (Neem)

et al. 2009

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“…This suggested the presence of the g-lactone group attached to C-17 in 12 which was supported by the 13 ) and molecular modeling 30) supported the relative configuration of 12.…”

Section: T Akihisa T Noto a Takahashi Et Almentioning

confidence: 69%

Melanogenesis Inhibitory, Anti-Inflammatory, and Chemopreventive Effects of Limonoids from the Seeds of Azadirachta indicia A. Juss. (Neem)

et al. 2009

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“…It is used in treat ment of anemia, convulsion, atherosclerotic cardiovascular disorders, high blood pressure, hyperglycemia, dyslipidemia, arthritis, liver problems and inflammatory conditions. [14][15][16][17][18].Phytochemically, it contains tannins, hence it purgative,anti-asthmatic, antitussives and anti hay fever effect [19][20][21]. Others include terpenoids an anti-feedant with insecticidal property [20,21].…”

Section: Introductionmentioning

confidence: 99%

Phytochemistry and Toxicity Studies of <i>Telfairia Occidentalis</i> Aqueous Leaves Extract on Liver Biochemical Indices in Wistar Rats

E¹,

E²,

S³

2012

AJMMS

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This study assessed the effect of oral ad ministration of aqueous extract of Telfairiaoccidentalis (TO) leaves on liver biochemical indices in Wistar albino rats. Fifty rats weighing 150-200g were div ided into 2 groups A and B, to test for acute (10 days) and sub-acute (4 weeks) effect respectively. Each group consisted of 25 rats, which were fu rther div ided into 5 sub-groups 1, 2, 3, 4 and 5. Sub-group 1 served as control and was orally gavaged with standard animal feed only, while sub-groups 2, 3, 4 and 5 were the test groups. In addition to the standard animal feed, 500mg/kg, 1000mg/ kg, 2000mg/kg and 4000mg/ kg of the extract was orally gavaged to the test groups 2, 3, 4 and 5 respectively. The standard animal feed g iven to the control and test groups contained the same amount of daily calories and protein. The acute and sub-acute administration of the extract caused significant differences in values of Aspartate amino Transferase(AST), Aspartate to Alanine amino Transferase(AST/ALT) rat io, Total protein, A lbumin, Globulin, Albu min/ Globulin ratio, Total body weight, Total and Conjugated bilirubin (P < 0.001) between test and control groups. Seru m levels of other parameters were statistically non-significant. There was no obvious evidence of hepato-toxicity detected in this study.

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“…The main features of them are similar to tetracyclicterpenes (liminoids) such as azadirachtin, meliantrol, salanin etc. and these compounds exhibit a wide variety of biological activity, [6] Leaves mainly yield quercetin (flavonoid), nimbosterol (ß-sitosterol) and liminoids (nimbin phosphorus, vitamin C, carotene etc. are also present.…”

Section: Azadirachta Indicamentioning

confidence: 99%

In Vitro Studies on the Effect of Azadirachta Indica Linn. In Lung Cancer A549 Cell Lines

Sathyamurthy¹

2017

WJPPS

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The leaves of Azadirachta Indica Linn is regarded as "sarvaroga nivarini' plant commonly used in traditional medicine by many Asian and Middle Eastern Countries to treat antibacterial, antifungal, anticancer and many other diseases. This leaves extracts are found to have antioxidant and anticancer activities. Liminoidsis the principle compound which is responsible for all its beneficial effects. The aim of our study is to analyse the biological effect of Azadirachta Indica L. in Lungs cancer A549 cell line. We found methanol extracts of Azadirachta Indica L. leaves contains phytochemical compounds having more free radical scavenging as well as anticancer activities.

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Isolation and characterization of an antimalarial agent of the neem tree Azadirachta indica

Cited by 159 publications

References 8 publications

Melanogenesis Inhibitory, Anti-Inflammatory, and Chemopreventive Effects of Limonoids from the Seeds of Azadirachta indicia A. Juss. (Neem)

Melanogenesis Inhibitory, Anti-Inflammatory, and Chemopreventive Effects of Limonoids from the Seeds of Azadirachta indicia A. Juss. (Neem)

Phytochemistry and Toxicity Studies of <i>Telfairia Occidentalis</i> Aqueous Leaves Extract on Liver Biochemical Indices in Wistar Rats

In Vitro Studies on the Effect of Azadirachta Indica Linn. In Lung Cancer A549 Cell Lines

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