Isolation and characterization of anti-diabetic component (bioactivity—guided fractionation) from Ocimum sanctum L. (Lamiaceae) aerial part

Patil, Raju N; Patil, Ravindra; Ahirwar, Bharati; Ahirwar, Dheeraj

doi:10.1016/s1995-7645(11)60086-2

Cited by 62 publications

(26 citation statements)

References 32 publications

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“…It may be due to the presence of some bioactive compound in this fraction that effectively reduced the glucose metabolism. These results were similar to the previous report of the antidiabetic activity of Ocimum sanctum fraction by Patil et al (2011). α-glucosidase and α-amylase suppressors can extend the processes along the intestine, the time taken for carbohydrate absorption is prolonged, and blood glucose concentrations are decreased over the time curve (Hanefeld et al 2004).…”

Section: Insulin Levelsupporting

confidence: 92%

Antidiabetic and In Vitro Enzyme Inhibition Studies of Methanol Extract of Ocimum tenuiflorum Linn Leaves and Its Fractions

Mousavi

Salleh

Murugaiyah

2020

TLSR

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Highlights • The highest dose of methanol extract significantly reduced the blood glucose level compared to another dose. • The ethyl acetate-butanol fraction exhibited a stronger antihyperglycemic effect compared to chloroform and ethanolwater fractions. • The ethyl acetate-butanol fraction was identified as a best fraction to reduce a α-glucosidase and α-amylase enzymes activities and insulin level with low concentration compared to other fractions and acarbose.

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Section: Insulin Levelsupporting

confidence: 92%

Antidiabetic and In Vitro Enzyme Inhibition Studies of Methanol Extract of Ocimum tenuiflorum Linn Leaves and Its Fractions

Mousavi

Salleh

Murugaiyah

2020

TLSR

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“…Since lipid abnormalities accompanying with premature atherosclerosis is the major cause of cardiovascular diseases in diabetic patients, therefore ideal treatment for diabetes, in addition to glycemic control, should have a favorable effect on lipid profile. Cardiovascular diseases are listed as the cause of death in 65% people suffering from diabetes [26][27][28][29][30][31] . From this point of view, it is encouraging that the 15 day treatment of SC methanol extract brought down the elevated level of lipid profile such as total cholesterol, triglycerides to near normal level.…”

Section: Discussionmentioning

confidence: 99%

Antidiabetic and Hypolipidemic Effect of Methanol Extract of Stereospermum Colais Fruit in Streptozotocin Induced Diabetic Rats

Imran

Khan

Akhtar

et al. 2016

J. Drug Delivery Ther.

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Objective: To assess the antidiabetic and hypolipidemic properties of Stereospermum colais Fruit. Methods: Acute toxicity test was done to check the toxicity of Stereospermum colais fruit methanol extract at three dose levels was administered orally to streptozotocin (STZ) (40 mg/kg bw) induced diabetic rats for 15 days. The various parameters were studied including body weight, fasting blood glucose levels, plasma insulin, lipid profile, glycogen content, glycoslylated hemoglobin (HbA1c) and serum marker enzymes levels in normal, treated and diabetic rats. Histochemical analysis of pancreas was also carried out in normal treated and diabetic rats. Results: The treatment group with the extract at three dose levels showed a significant increase in the liver, muscle glycogen and serum insulin level and a significant decrease in fasting blood glucose, glycosylated hemoglobin levels and serum marker enzyme levels. The total cholesterol and serum triglycerides levels were also significantly reduced and the high density lipoprotein level was significantly increased upon treatment with the Stereospermum colais Fruit methanol extract. Histochemical study of pancreas also confirmed the biochemical findings. Acute toxicity studies revealed the non-toxic nature of the Stereospermum colais Fruit methanol extract. Conclusions: The results of the experiments presented here suggest that methanol extract of Stereospermum colais Fruit exerts significant antidiabetic and hypolipidaemic effect in STZ induced diabetic rats.

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“…Triterpenes are reported having anti-inflammatory activity. Similarly, these compounds are reported to be antioxidant (Fiorentino et al, 2007), antiparasitic (Danelli et al, 2009), antiviral (Kuo et al, 2009;Zhu et al, 2014), antifungal (Yuan et al, 2009), antibacterial (Yuan et al, 2009), antitumor, (Chen et al, 2010;Gordaliza, 2010;Kuo et al, 2009), antidiabetic (Castellano et al, 2013;Nazaruk and Borzym-Kluczyk, 2015;Patil et al 2011), antiulcerogenic (de Andrade et al, 2008, hepatoprotective (Li et al, 2017;H. Wu et al, 2016), neuroprotective (Koneri et al, 2014), analgesic (Nieto et al, 2013C.-R. Wu et al, 2010) etc.…”

Section: Isolation and Identification Of Insect Antifeedant Compound mentioning

confidence: 99%

Isolation and Identification of Insect Antifeedant Compound from Ethanol Extract of Hemidesmus indicus Root

Pillai¹,

Guendouz²,

Benniou³

2020

IJARe

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Phytochemicals with insect antifeedant potential can be used as a safer alternative to harmful chemicals that are used as grain protectants. The insect antifeedant effect of the extracts and fractions of Hemidesmus indicus root were tested against the stored grain insect pest Corcyra cephalonica Stainton. Bioactivity-guided study of ethanol extract of Hemidesmus indicus root led to isolation and identification of a triterpenoid, Lupeol with insect antifeedant potential. Although Lupeol showed insect antifeedant potential the ethanol extract was found to be more effective as an antifeedant. This implies that the synergistic action of compounds present in the ethanol extract of H. indicus root is responsible for the higher antifeedant potential.

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Isolation and characterization of anti-diabetic component (bioactivity—guided fractionation) from Ocimum sanctum L. (Lamiaceae) aerial part

Abstract: Our present study concluded that, tetracyclic triterpenoid isolated from aerial part of O. sanctum has a great anti-diabetic potential.

Cited by 62 publications

References 32 publications

Antidiabetic and In Vitro Enzyme Inhibition Studies of Methanol Extract of Ocimum tenuiflorum Linn Leaves and Its Fractions

Antidiabetic and In Vitro Enzyme Inhibition Studies of Methanol Extract of Ocimum tenuiflorum Linn Leaves and Its Fractions

Antidiabetic and Hypolipidemic Effect of Methanol Extract of Stereospermum Colais Fruit in Streptozotocin Induced Diabetic Rats

Isolation and Identification of Insect Antifeedant Compound from Ethanol Extract of Hemidesmus indicus Root

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